Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function

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Is Norepinephrine beta2 adrenomimetic?

I know that it has alpha1, alpha2 and beta1 effects. It has beta2 receptor where epinephrine can effect. However, to say that it is beta adrenomimetic, I am not sure. That is ligand binding beta2 ...
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Ephedrine or pseudoephedrine indirectly central alpha2 mimetic?

I started to think this problem by first thinking if the alpha2 mimetism is possible in either case. It seems to be indirectly in either one. Ephedrine seems to have more prominent effect in CNS. ...
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5 views

Can choline-receptor stimulatants block cholinesterase inhibition?

I am thinking what are the possible options of terminating suxamethonium i.e. succinylcholine activity. Succinylcholine is enzymatically hydrolyzed by plasma cholinesterase. Can choline-receptor ...
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Quetiapine tolerance

I've researched quetiapine for quite some time now and I've found some references to tolerance, but nothing conclusive. My question is whether quetiapine use builds tolerance to the drug and if so, ...
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23 views

Types of protectants for NSAIDs? [closed]

Coating drugs or protectants. I think possible types intestinal protectants such as Laxative and Cathartic skin protectants (those supporting the elasticity of the skin) What other types of ...
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Why is drug clearance not affected by blood flow in case of low extraction ratios?

Background information: 1) Variation of organ blood flow: a) for drugs with low extraction ratio (<0.3): the venous drug concentration is virtually identical to the arterial concentration ...
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1answer
16 views

What is the most common way of administering loop diuretics and what is their time course of action?

I am reviewing some material on loop diuretics, and I am curious to know how these drugs are administered. Also, I am interested in knowing their time course of action once they are administered into ...
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1answer
23 views

Does vitamin D form crystals in the blood with calcium and magnesium?

I read on a vitamin-D product (2000NE) that I should not use calcium and magnesium with it, because it can result crystal formation in the blood. I googled, but find anything about this. Is it true? ...
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94 views

What are the psychedelic effects of (stellar) anise and how many people are affected?

Backstory: My girlfriend reacts heavily to chocolate and drinks containing stellar anise, in a way that seems comparable to psychedelic drugs. After consuming it, it takes approximately five minutes ...
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2answers
64 views

Why does caffeine give you so much energy, while being so low on calories?

There's definitely something I'm missing here. Since calories is a unit of measurement for energy, and caffeine seemingly gives you a lot, how can the labels on caffeinated products have such a low ...
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1answer
93 views

Do SSRIs downregulate or upregulate the 5-HT3 receptor?

What effect do SSRIs have on the expression of the ligand-gated ion channel, the 5-HT3 receptor?
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1answer
24 views

What are the reactions in the body that triggers dizziness after cigar(nicotine) smoking in non-smokers?

Suppose there is a person that has never used nicotine in any form in his/her life. Why does the person get dizzy after a few "shots" from a cigar(nicotine)? What's the difference between using other ...
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1answer
11 views

What enables azacitidine to incorporate into both DNA and RNA?

I did a mini-project on the drug azacitidine for my pharmacology class, and I learned that azacitidine has the ability to incorporate into both DNA and RNA. I think this is really unique because a ...
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1answer
31 views

Concentration of caffeine in physiologically relevant setting

Caffeine is known to overcome G2/M (and possibly other types of) cell cycle arrest through its effects on DNA repair machinery and is used as a positive control in studies of cell cycle arrest. In ...
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1answer
27 views

Difference between medicinal caffeine and regular caffeine

There are some OTC paracetamol tablets, some with caffeine. Is this caffeine the same as the regular caffeine (found in a coffee)? Does it perform better than it in any way?
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1answer
42 views

Which immunosuppression caused by long-term usage of these antibiotics in untreated celiac disease?

These antibiotics include amoxicillin + acidum clavulanicum (beta-lactam, inhibit cell wall synthesis, broad specturm, 3rd gen aminopenicillin) / last part preventing the resistance ceftriaxone (3rd ...
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1answer
228 views

How do the pharmacodynamics of the NSAIDs differ and are there “resistant” COX phenotypes?

I know that the non-steroidal anti-inflammatory drugs (e.g., aspirin, ibuprofen, naproxen) affect the enzymes cyclooxygenase (types I and II). Is there any difference in the degree to which these ...
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2answers
151 views

Why do different pain killers have different effects on people?

I've noticed some pain killers working great for me, while other having no effect. Works for me Aspirin APC † Naproxen Doesn't work for me Paracetamol Diclofenac Tramadol I doubt there ...
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18 views

Is there a known glucosepane cross-link breaker?

I read the following on wikipedia: There is, however, no agent known that can break down the most common AGE, glucosepane, which appears 10 to 1,000 times more common in human tissue than any ...
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1answer
9 views

What studies are there showing the effectiveness of any substance on canine hypertension?

Searching on http://www.ncbi.nlm.nih.gov I could only find the article titled as "Telmisartan Treatment of Refractory Proteinuria in a Dog".
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1answer
25 views

How does fluorouracil inhibit pyrimidine synthesis?

I was reading in my pharmacology textbook about fluorouracil, and my book mentioned that fluorouracil is an antimetabolite whose function is to inhibit pyrimidine synthesis. However, I was curious to ...
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21 views

Thermochemistry of gabapentin

So I am taking a new class at my institution called Theoretic Nuclear Thermochemical Pharmacology, (I know big name, it's an elective from a real pioneering fronteirsman in our department :P) and I am ...
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1answer
19 views

Meta-analysis of fruits in blocking Cytochrome family

My professor says that some drugs cannot be used with grapefruit. I am trying to search a list of cytochromes and their effect to block members in the cytochrome family. Some in Cyt P450. What is ...
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2answers
1k views

Why is Paracetamol so great?

Every time I get ill (cold, flu etc) I take a couple of these wonderful tablets for up to 4 times a day and I, eventually, get better. What exactly is paracetamol? Why is it so effective and is it ...
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36 views

Drugs metabolism and detection

If someone is taking treatment for a psychiatric disorder, for example diazepine, would traces of the metabolized drug show in their sweat or saliva? Would it be chemically detectable?Any links to ...
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1answer
29 views

What is meant by drug tolerance?

What is meant by drug tolerance? This question is in my biology textbook for IGCSE and I have no idea what drug tolerance is. It would be very helpful if someone could clarify. Thank you.
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86 views

Are there any situations in which phenylephrine is preferred to pseudoephedrine?

In the mid 2000s in the US, due to issues of drug enforcement, pseudoephedrine containing medications were brought behind the pharmacy counter and in most cases require ID, and phenylephrine was ...
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12k views

How does laughing gas (N2O) work?

Laughing gas (N2O), well, makes people laugh. How does just a gas make us do that, there has to be some hormones at work... So, I wanted to know how this works? What is the mechanism?
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2answers
53 views

Pharmacology: Drug Administration

Why is the enteral route seem by far the most common way to administer a drug to the body?
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1answer
80 views

Pharmacokinetics: why do certain drugs follow zero-order kinetics?

I understand that alcohol and phenytoin are two examples of drugs that follow zero-order kinetics. Why do these two particular drugs follow zero-order kinetics as opposed to first-order kinetics?
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2answers
274 views

Are there dangers to Teflon and aluminium cookware?

I've been reading some articles on the internet about dangers of Teflon and aluminium to the body. My family say I'm just exaggerating the situation, and maybe I am, though I'm not sure because not ...
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1answer
42 views

Applying drugs to brain via scalp (transdermal)

Many medications are intended only for the brain, but are taken orally. Hence <10% finds its intended target, while the remaining >90% is at best wasted, and at worst causes unwanted side-effects. ...
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99 views

How does Sodium Valproate cause neural plasticity

I have been reading a fascinating paper: Valproate reopens critical-period learning of absolute pitch 18 individuals were given Sodium Valproate (VPA) for a fortnight during which they trained on a ...
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39 views

Compatibility drugs info

Let's suppose that I take a DrugA for ProblemA and then I got this ProblemB and started to take DrugB. Are there general rules I can look up to figure out whether I can take DrugA & DrugB ...
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1answer
157 views

What's the therapeutic index of Pethidine (Meperidine in the US)?

What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window ...
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13k views

Why do vaccines cause your arm to hurt?

When you get a shot for a vaccine (for example, the annual flu vaccine), the nurse frequently indicates that your arm will ache for a day or two, maybe more. This ache is typically not just a pain ...
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2answers
75 views

Can a fungus become resistant to a chemical such as Potassium Permanganate?

A friend used potassium permanganate solution to treat tinea on the hands/feet but after some initial success, the tinea seems to be making a comeback. Could the fungus develop resistance to potassium ...
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1answer
293 views

How does the eugeroic modafinil work?

How does the drug, modafinil (Provigil), exert its eugeroic (wakefulness-promoting) effects? I've read that it works by increasing dopamine and histamine concentrations in the CNS and by serving as a ...
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1answer
39 views

What Effect would Cannabinoids have on the Acute Porphyrias?

I should be clear in saying that this question is NOT intended for personal medical advice. Rather what I am looking for is journal articles and/or books that touch on this subject because I think it ...
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1answer
58 views

Mesoporous silica particles as anti cancer drug delivery method

If this question is a little off topic for Biology, I'm sorry. I've recently read a lot about mesoporous silica nanoparticles as a promising drug delivery method. The huge range of customizability of ...
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1answer
60 views

Is there any completely Computation Drug ever launched in market?

I am working in bioinformatics(part of it in Drug Designing) for years, still if I have no idea about it. As it is too hard to prove (Pass all Clinical trials) and get FDA Approvals. So, My question ...
2
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1answer
119 views

What is LD50 for 25i (25I-NBOMe)?

Firstly I would like to apologise if this is not correct place to ask this question, as it can be seen more as chemistry and not biology question. I was looking around for data on psychedelic ...
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1answer
52 views

Can neurotransmitter depletion cause short-term drug tolerance?

I'm curious to know if neurotransmitter degradation factors into drug tolerance and neural conduction and, if so, to what extent. As I recall from textbooks I read as an undergrad, one mechanism of ...
4
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1answer
94 views

Beetroot white skin mould

Does a mould make a beetroot poisonous or inedible ? Lemon's mould for instance, makes penicillin, but it's green there, and I'm allergic to penicillin, would the white mould produce penicillin too? ...
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1answer
42 views

Preventing paracetamol overdose

Paracetamol overdose is one of the most common drug toxicities. It may be treated by intravenous N-acetylcysteine which replaces the glutathione that is used up in paracetamol metabolism to prevent ...
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1answer
125 views

Pharmacologically, can tricyclic antidepressants have a side-effect profile similar to neuroleptics?

Torticollis (wryneck, cervical dystonia) is a neurologic movement disorder causing involuntary muscle spasms in the neck. Often, neuroleptics can cause such a side effect. I'm wondering if this ...
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1answer
28 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
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1answer
69 views

Does tea have its effect if you have a sleep after drinking it?

If I drink tea, then go to sleep for a while, when I wake up, will the effect of tea still be on me (the refreshing effect)? Does it depend on the duration of sleep?
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19 views

Is there a definitive theory of how general anesthesia works?

Is it true that the method of action of general anesthesia is not exactly known? In other words, is there no conclusive theory of how it works?
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52 views

Does Yerba Mate contain Beta carbolines like harman and norharman?

I know that this is true of (roasted) coffee but haven't been able to find any reliable information about mate in its smoked or steamed state. Thank you.