Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function

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How to determine sensitivity in a dose-response curve?

In a dose-response curve the % inhibition can be plotted against concentration antagonist. In our case, the effect of the antagonist is tested in different genetic variants of a microbe. When trying ...
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60 views

Can Opioids Attenuate some of the symptoms of Psychosis?

Can Opioids Attenuate some of the symptoms of Psychosis? I ask because there's a dead link on the Wikipedia page that's meant to support the notion that opioids attenuate some of the symptoms of ...
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How does drug-induced photosensitivity work?

Some drugs (tetracyclines, for instance) can cause photosensitivity reactions—that is, some patients become extremely sensitive to the sun, developing rashes or inflammation after spending time ...
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Does DHA increase the effects of clarithromycin?

I've read on this publication that every drug that induces CYP3A can reduce the effectiveness of clarithromycin. Clarithromycin inhibits CYP3A. But it does not say anything about the opposite ...
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If D1 receptors stimulate adenylate cyclase (through GPCRs) and D2 receptors inhibit it, then why do mutations in both have similar effects?

D1 and D2 both refer to specific types of dopamine receptors. I'm sure it has something to do with the fact that the D1 receptors are in regions different from D2 receptors. I know that adenylate ...
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11 views

What are necessary parameters for a tissue scaffold to be biodegradable?`

I am a mechanical engineer with little biological experience, but I have recently been looking at tissue scaffoldings. My current understanding is as follows, but may be flawed. I would appreciate ...
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2k views

What are potential side effects of myostatin inhibitors?

Myostatin inhibitors, which are being developed to treat muscle wasting diseases like muscular dystrophy, are likely to be abused by athletes. What are the potential long-term side-effects of taking a ...
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123 views

Is there a Pharmacology Textbook that Satisfies the Conditions listed in the Body of this Question?

The conditions are: As extensive and explanatory as Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition With additional extensive and thoroughly explanatory information ...
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72 views

What's the Efficacy of Ampakines in the Treatment for ADHD?

What's the Efficacy of Ampakines in the Treatment for ADHD? Ampakines are a class of drugs that serve as potentiators of the AMPA glutamate receptor. By so doing they serve as nootropic, anxiolytics ...
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13 views

How do macromolecules (large drugs) in the eye reach the bloodstream and what are the relative significances of these pathways?

I am considering the elimination pathways for antibodies (50-150 kDa) from the vitreous humour to the blood stream. My overarching question is what is the most significant route such antibodies could ...
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28 views

Genotype-Phenotype databases?

Beyond the Stanford HIV database, what other databases out there provide a dataset linking virus/bacterial genotype to quantitative phenotype? I'm looking for high quality datasets to test machine ...
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33 views

Birth control hormones in the water? Or not?

This prior question talks about natural estrogen (TL;DR: Months to years): How quickly do estrogens break down in the environment? Ref: http://dx.doi.org/10.1038/485441a A lot of media has said, ...
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18 views

Source of journals collecting titles of scientific publications regarding clinical trials with dogs fed medicinal herbs

After some time researching on the web, you can find a lot of websites telling you that some herbs may have or have specific properties(unfortunately most seem to be "advertised" as if they were ...
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38 views

Can I explain the kinetics of a ligand looking at the ligand-protein co-structure?

Can I explain the kinetics of a ligand binding to a target protein (association and dissociation rates) by looking at the protein-ligand co-structure? Editing my question after a few comments: I ...
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279 views

IC50 and area under the curve

I was hoping to get some clarification on how drug response data (i.e. IC50) are presented. On publicly available datasets like Genomics of Drug Sensitivity in Cancer, area under the curve (AUC) ...
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13 views

Imidazoline receptor agonist in clonidine?

I am thinking which pathway is more important in hypertension, ADHD and withdrawal of clonidine: alpha-2 agonist imidazoline receptor agonist (maybe) Alpha-2 is the classical one. Pubchem starts ...
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17 views

Why is there only adrenoreceptors and no active adrenergic innervation in bronchus and uterus?

Our bronchus and uterus has beta adrenoreceptors, but they have no active sympathetic nervous system innervation in these organs. Was there a sympathetic innervation in trachea and uterus, earlier, ...
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171 views

negatively charged albumin as major carrier of acidic/negative charged drugs in blood

I reading that orsomucoid (alpha-1-acid glycoprotein) is the major carrier of positively charged (basic) drugs in the blood, while albumin carries negatively charged (acidic) and drugs with neutral ...
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152 views

Why can't sodium butyrate be delivered orally in humans and other mammals?

I think I know why -- bioavailability problems but since I have no firm evidence to support this theory I thought I would ask the biology stackexchange community for their input. I'd like some firm ...
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23 views

Which classes of drugs (filed by their pharmacology) induce a release of β-endorphin?

Which classes of drugs (filed by their binding sites) induce a release of β-endorphin? I know of agonists of the nAChRs and 5-HT1A and ethanol. Are there any others? Please cite journal articles ...
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646 views

How do Opioids Stimulate a Histamine Release?

Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...
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40 views

Western blot extrange band

I performed a WB using plasma rats and monkeys samples with anti ubiquitin K-48 antibody. In every sample the antibody binds something and it appears a specific band that seems to be 71kDa. When I ...
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15 views

What is the permeability of proteins across the hyaloid membrane of vitreous to retina?

Does anyone know of any experimental work to test the permeability of the hyaloid membrane between the vitreous humour of the eye to the retina to proteins? Currently the largest molecule I can find ...
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11 views

What's the relationship between Drugbank drugs and SMPDB pathways?

In the 'pathway browse' panel SMPDB pathways and their corresponding Drugbank drugs are listed. What are the relationships between the drugs and the pathways? Some listed drugs are not in the ...
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54 views

Are ipratropium and tolterodine parasympatholytic?

They are nonselective cholinoblockers and antimuscarinic. Other cholinoblockers of parasympaticus, which I know, are parasympatholytic such as atropine, butylscopolamine, trihexyphenidyl, titropium ...
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29 views

Why is drug clearance not affected by blood flow in case of low extraction ratios?

Background information: 1) Variation of organ blood flow: a) for drugs with low extraction ratio (<0.3): the venous drug concentration is virtually identical to the arterial concentration ...
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42 views

Thermochemistry of gabapentin

So I am taking a new class at my institution called Theoretic Nuclear Thermochemical Pharmacology, (I know big name, it's an elective from a real pioneering fronteirsman in our department :P) and I am ...