The study of the normal function of living organisms and the means by which it is achieved.

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Can an upper forearm amputee correctly control the Median and Ulnar nerves

I'm an engineer who is looking to build a robotic hand for people without their upper forearm(from center of forearm in direction of hand), controlled by the Thalmic Myo(an EMG sensor). I am first ...
2
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2answers
92 views

Calcium levels and nerve hyperexcitation

Why does lower blood calcium levels (or lower calcium levels in ECF) cause nervous hyperexcitaton? Why does it cause over stimulation of nerves and muscles and spasmic contractions of muscles? This is ...
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2answers
33 views

What’s the reason for isovolumic contraction and isovolumic relaxation?

During cardiac cycle, there are two periods in which the heart volume doesn’t change, but there is a change in tension/pressure. It takes about 0.25-0.35 second to achieve this change. I searched in ...
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1answer
39 views

What specific sensory nerves act as receptors for “pins and needles” (neuropathy)?

According to this excellent answer, the difference between "pain" and "pins and needles" (neuropathy) is that different receptors (sensory nerves) trigger in reaction to different stimuli. Different ...
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0answers
20 views

How does the intra-esophageal presure affect the lower esphageal sphincter?

I know that the lower pressure in the thorax will cause the esophagus to have a lower pressure but someone told me that this forms a part of the physiologic lower esophageal sphincter. How so? ...
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0answers
35 views

How is atrial muscle stimulated, when the Atrioventricular (AV) Node is heart main pacemaker? [closed]

When the sinoatrial (SA) node is blocked, the atrioventricular (AV) node is heart pacemaker and controls ventricular contraction. The heart then beats 40-60 times per minute. What happens to atrial ...
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0answers
30 views

Zoology versus Physiology versus Physics [on hold]

How Physiology is different from zoology and physics? Physiology is the study of mechanism of living system but does it deal with such thing that are dealt by physics like kinetic energy and velocity ...
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2answers
120 views

Why do skin and nail go blue in cyanosis?

I have learned that Cyanosis presents with blue skin and nails. What is the reason for the blue coloration of the skin and nails? Why wont the skin and nails turn another color in the visible spectrum ...
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1answer
48 views

Is there a known glucosepane cross-link breaker?

I read the following on wikipedia: There is, however, no agent known that can break down the most common AGE, glucosepane, which appears 10 to 1,000 times more common in human tissue than any ...
5
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3answers
57 views

How does vasoconstriction/vasodilation change blood pressure?

Background: I am coming at this question from an electrical engineering background, and I feel like I am missing certain assumptions that are going into the statement found in my physiology textbook, ...
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2answers
102 views

What is the name of the condition where no pacemaker cells are active in the heart for a short-time?

Assume that the heart is beating, but no pacemaker cells are working for at least 15 seconds. This would be a very long compensatory pause if extrasystole started it. There may be some low frequent ...
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1answer
38 views

How can succinylcholine cause myorelaxation?

I first thought that this is because of prolonged depolarisations. However, I am not sure anymore, because after reading PubChem, the only possible pathways are are Choline agonist. So I would say ...
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0answers
14 views

Why am I feeling more hungry when lying on my back? [closed]

I noticed that when I lie on my back I feel more hungry than in all other positions. How is it possible?
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2answers
75 views

How can we measure cardiac output?

I could find a way which could find it by body oxygen consumption and there is another way to measure it by injecting drugs — measuring cardiac output by the so-called “indicator dilution method,” a ...
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2answers
79 views

Why can't we defibrillate the heart within 1 minute after ventricular fibrillation by electroshock?

We mostly can defibrillate the heart before 1 min of ventricular fibrillation by electroshock.Then we often can't do defibrillate it with electroshock. What's the reason and What's the best way to ...
5
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1answer
36 views

Why do the size of the phase 1 notch vary among cardiac cells?

The size of the phase 1 notch varies among cardiac cells. It is prominent in myocytes in the epicardial and midmyocardial regions of the left ventricular wall and in ventricular Purkinje fibers. ...
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1answer
97 views

Why do ion concentrations change with different secretion rates in pancreatic juice?

Why is it that when secretory rate increases in the pancreas the concentration of chloride ions decreases, and the concentration of bicarbonate increases in the production of isotonic NaCl secretion? ...
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1answer
165 views

Why doesn't HDL cause diseases like LDL?

LDL particles pose a risk for cardiovascular disease when they invade the endothelium and become oxidized, since the oxidized forms are more easily retained by the proteoglycans. A complex set of ...
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1answer
79 views

Why do men have a higher hematocrit (red blood cell count) than women?

The hematocrit, also known as packed cell volume (PCV) or erythrocyte volume fraction (EVF), is the volume percentage (%) of red blood cells in blood. It is normally 45% for men and 40% for women. ...
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2answers
139 views

Why don't we see turbulence in the aorta even in normal situations?

I read about the Windkessel effect. Then I read about pulse pressure waves getting reflected from the periphery. If the pulse pressure wave is reflected during diastole and at the same time blood is ...
5
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1answer
167 views

Is a raised baseline between T and QRS normal in any ECG lead?

Here are excerpts from an unknown ECG lead. I find it weird that the "baseline" changes after the T wave and doesn't return until after the following QRS complex. Is that normal/expected for any lead? ...
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1answer
36 views

Does repolarization of muscle fibers mean that the muscle bundle is relaxed?

If I flex my bicep and continue to contract it does it mean that the muscle cells are in depolarizing state and not repolarizing?
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1answer
68 views

Can humans live without their right atrium?

The right atrium is one of four chambers (two atria and two ventricles) in the hearts of mammals (including humans) and archosaurs (which include birds and crocodilians). It receives deoxygenated ...
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1answer
52 views

Voltage-gated Potassium channels in the action potential of cardiomyocyte?

There is one type of potassium voltage-gated channels open in Phase 1 too. Some call them early repolarization channels. I am not convinced that the channels are different in different phases: 0, 2, ...
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4answers
64k views

What's the maximum and minimum temperature a human can survive?

This is a question that has been in my mind since I was a kid. I'm not a doctor, nor even a biology student, just a curious person. What is the minimum and maximum temperature a human body can stand ...
2
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2answers
129 views

What is atrial fibrillation? [closed]

I am wondering exactly what a-fib is (causes and symptoms). I would really appreciate having a sample of an EKG with it (because in my limited research, I have found it nearly impossible to find just ...
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1answer
1k views

Why do we experience temperatures below 37 degrees Celsius as 'hot'? [duplicate]

We always prefer to be in 20-25° C, although our core temperature is about 37°? Why is our skin temperature lower than our core temperature?
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1answer
150 views

Hydrogen Peroxide on Open Wounds

I know that H2O2 is a chemical with high oxidative potential. It can deliver nascent oxygen which can destroy bacteria. I understand that open wounds have cells that are dividing at a fast rate to ...
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1answer
76 views

What's the worst that can happen from too much sleep deprivation? Can you die?

It is well known that sleep deprivation causes considerable discomfort in humans (and has even used as a form of torture), but nevertheless there have been people who went through protracted sleep ...
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1answer
22 views

How is oxygen and carbon dioxide exchange mediated by hemoglobin? [closed]

Oxygen is transferred by hemoglobin from the lungs to tissues, while carbon dioxide is transferred by hemoglobin from tissues to lungs. How is this regulated bidirectional transfer mediated?
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1answer
29 views

What is the effect of persistent hypothermia on cardiac performance?

I define persistent hypothermia in this thread about the mechanisms of persistent hypothermia. The Graph of Katzung et al. in Pharmacology about Heart Failure: I am thinking which parts here are ...
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1answer
62 views

Does transplanted heart have full sympaticus without medication?

I am reading this and this where I am considering this sentence [N]o baseline parasympathetic innervation [in transplanted heart]. Does this sentence imply that the heart work then in full ...
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2answers
53 views

Does the cellular response to every receptor work the same way?

I heard somewhere that activating any receptor results in the same intracellular response (signaling) which involves NF-κB. If that is true, I hardly understand how the cells distinguish between ...
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2answers
92 views

Which fruit compounds affect the speed of fructose absorption?

Blood fructose levels are not regulated by insulin in the human body. This means that the body absorbs pure fructose very fast, and it raises the blood fructose levels rapidly. Do fruits/ vegetation ...
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0answers
51 views

Are small CO₂ concentrations devastating to certain cognitive tasks?

A new study shows strong effects of what should be a negligible CO2 concentration. The paper "Is CO2 an Indoor Pollutant? Direct Effects of Low-to-Moderate CO2 Concentrations on Human Decision-Making ...
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3answers
980 views

Do snakes get dizzy?

I've seen snakes get captured in sacks and I've wondered if the snake would get dizzy if the sack were twirled around. I have not done any tests (and don't plan to) because snakes scare me.
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1answer
120 views

Duplicity Vs. Singularity of Mammals Organs [closed]

Are there known evolutionary reasons why mammals contain 2 of some organs (such as lungs and kidneys) and only 1 of some (such as liver)?
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2answers
981 views

Why do we get runny noses in the cold?

The most annoying thing for me about being cold is a runny nose. Is there an advantage to having a runny nose when cold? What does having a runny nose achieve?
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1answer
93 views

What is the physiological difference between cortisone and cortisol?

There is only hydrogen bond different. Cortisol is synthesized by our body, while cortisone is given to the patient. Why you cannot give cortisol directly to the patient? I think the reason is ...
3
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1answer
90 views

Elevated position effect on recovery times from upper respiratory infections at rest?

In nursing school, they advice for people with upper respiratory infections to be in a slightly elevated position at the head region when sleeping. My intuition of the reason is that the lymphatic ...
3
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1answer
49 views

Hypersensitivity Simultaneously in Ear canals

I got experimental data where hypersensitivity (i.e. tonic pain when touching ear canal) was recognised for about 100 minutes. I do not know which type of hypersensitivity is this one. IgM can ...
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0answers
30 views

What are the mechanisms of disabling extrinsic control of heart?

I started this thread by thinking this question but I developed it further below What is the mechanism maintaining refractory period of pacemakers? My conjecture is that the mechanism is the ...
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0answers
62 views

What is the nature of action potentials in autonomic nervous system?

My conjecture is that the natures of sympathetic and parasympathetic action potentials are different. My findings propose me that sympathetic action potential is little longer lasting than ...
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0answers
33 views

Can non-carbonated energy drinks boost alcohol intoxication?

I just read news article about banning caffeine in alcohol drinks and about that energy drinks increase the urge to drink alcohol. Energy drinks cause sugar intoxication - answer about it here ...
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1answer
30 views

What is the quality rate of intrinsic autoregulation in the heart?

Autoregulation is the maintenance of constant blood flow to an organ in spite of fluctuations in Blood pressure. It involves the relaxation of myocardium and contraction. It is local. I know that ...
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0answers
43 views

How is Calcium regulated in myocardic AP and plateau phase?

The plateau phase is maintained by influx of calcium and outflux of potassium in the second stage: My conjecture is that calcium transforms between two phases ionated phase (free calcium from i/c ...
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1answer
42 views

Double use of ATP in relaxing myosin & active transportation of calcium?

Is the ATP molecule which is bound to the myosin head for relaxation of the muscle (i.e., to break the cross bridge) also utilized for active transport of calcium to the sarcoplasmic reticulum during ...
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1answer
49 views

Does pupil size affect image focus in persons with no lens?

If an individual has no lens like Claude Monet (who had them removed). They should be able to still focus the images they see in a well light area if they shrink their pupils to a very small size ...
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2answers
225 views

How is membrane capacitance related to the increased speed of saltatory conduction?

Here is the original question which inspired my question. As explained by the answers there, the reason saltatory conduction in myelinated neurons is faster than non-myelinated conduction is because ...
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1answer
30 views

How does anadromous fish physiology “know” to switch from salt to freshwater and back?

What mechanism allows anadromous fish (like salmon) to switch from salt to fresh water and back? How does the fish "know" to switch its physiology and do other fish possess the biochemical machinery ...