The study of the normal function of living organisms and the means by which it is achieved.

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57 views

Given an EC50 value, how do I reproduce the sigmoidal curve from which this was calculated?

All-trans retinoic acid (atRA) is a potent ligand for a nuclear receptor called retinoic acid receptor alpha (RARa). The concentration of atRA at which RARa is half maximal is 19nM. The dose-response ...
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39 views

Case Study and speculations of Edward Mordake

I am very interested in the case of the man named Edward Mordake who lived in the 19th century. In particular, he had two faces. If you have not heard of this man, please, search this up as there are ...
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26 views

Blood as newtonian flow and Poiseuille law [closed]

For a prep exam: A healtly pacient has a carotid with the following characteristics: intern ratio: ๐‘…= 2.8 mm, ๐‘ƒ2 = 89 ๐‘š๐‘š๐ป๐‘”, ๐‘ƒ1 = 90 ๐‘š๐‘š๐ป๐‘”, ๐œ‡blood = 3.5 cp, ๐ฟ=10.0 cm. Using the ...
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1answer
67 views

How to define drug-resistant or -sensitive cell line when knowing the IC50 values?

I have got the IC50 data for a drug on different cell lines. How to define if the cell line is sensitive or resistant towards this drug? Could anyone tell me how to define this?
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2answers
324 views

Why do we urinate more when we are nervous?

This question is a result of my personal experience... But I guess that is common for many of us. My school timing is 8:00 am to 1:30 pm (usually). During normal school days I typically urinate one ...
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1answer
20 views

How is circadian rhythm of gastric acid secretion regulated?

Gastric acid secretion shows a circadian rhythm where acid production in the morning is minimal and it reaches a maximum towards the evening. How is this process regulated?
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3answers
135 views

Resilience to the neurotoxins of Indian King Cobra

I read on Wikipedia about this: King Cobra - Wikipedia In Thailand, a concoction of alcohol and the ground root of turmeric is ingested, which has been clinically shown to create a strong ...
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2answers
362 views

Why can newborns swim?

I am wondering for someone to discuss the phenomena that newborn babies (humans) are able to submerge underwater up until a few months where that ability is lost again? What is the explanation for ...
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2answers
144 views

Should we induce fever to assist healing?

I am currently reading "The Fundamentals of Anatomy Physiology" 10th edition, and have found it an incredibly interesting book. I have just been reading about the lymphatic system, and the various ...
4
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1answer
158 views

How do animals handle light refraction in different media?

For a human, when diving underwater, everything is blurry because of the water's different refractive index compared to that of air, which we are accustomed to. How do animals, like turtles, seals or ...
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3answers
3k views

Is there any use of COโ‚‚ in human body?

We all know COโ‚‚ as a waste product of metabolism . Does COโ‚‚ have any helpful role , apart from having a role in pH of blood ?
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230 views

What physiological processes within a muscle cause the latent period in a muscle fiber?

This is a lab question I cant find the answer in the lab manual or in the text book. What physiological processes in a muscle cause the latent period in a muscle fiber? Please help. Edit: The latent ...
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5answers
112 views

Is the amount of blood that flows through every vein and artery per minute really a constant?

I was listening lectures from Mark Saltzman via Open Yale Courses. Now, if I did not understand him wrong, he said that the amount of blood that travels through every vein and artery in our bodies per ...
5
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1answer
62 views

Is hands-only CPR as effective as traditional CPR?

Is hands-only CPR as effective as traditional CPR ? Wouldn't 30 chest compressions + 2 rescue breaths be more effective if the person doesn't have a pulse AND not breathing? From my understanding ...
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3answers
1k views

Do women experience more bonding hormones than men after sex?

Does Oxytocin (or any other bonding hormone) increase more so for women than for men after sex? Someone told me that it increases 4-fold for men and 12-fold for women (unconfirmed). Is there any ...
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1answer
50 views

Is Norway spruce (Picea abies (L.) Karst.) isohydric or anisohydric species?

Question from a thesis defense list ask me this. But I can't find the exact answer on the internet or in books. In my thesis, I described isohydric plants, for example maize, lupin, pea, poplar. This ...
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1answer
98 views

Do people that don't feel pain shiver in the cold?

There are a few diseases that cause an insensitivity to pain. This question asks about the relationship between the cold and pain, which got me thinking: Is shivering a response driven by the ...
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3answers
105 views

Does the necessary Carbon Dioxide need to be in the atmosphere for mammals?

In the answers to this question, we've learnt that carbon dioxide is necessary for mammalian life, but is it necessary in the atmosphere/to breathe it in? Or does the act of respiration give a ...
2
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1answer
40 views

Detailed mechanism of the cause of diabetes mellitus type 1?

I have read in some texts that diabetes mellitus type 1 is caused by degeneration of beta cells due to our body's own immune reaction.Is it true? Can you explain further how are such types of immune ...
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0answers
38 views

Normal ECG/EKG Measurement?

I'm getting started using ECG using a 3 lead system by iWorx. I have place the leads on my two wrists and the ground on my ankle and have recorded some data into the provided LabScribe 3 software ...
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0answers
26 views

how food moves in horizontal coils of small intestines [duplicate]

This is a very very basic question, and I am looking at it more from point of view of physics. The small intestine is a highly coiled structure, which means it has horizontal coils as well. I can ...
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1answer
48 views

How does ANF increase GFR?

ANF as we know reduce the Na+ uptake and K+ removal in the distal tubules and it also functions as a Vasodialator (?) But again it says that ANF increases the Glomerular filtrate ? But if it is acting ...
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1answer
23k views

Why are (some) cats attracted by bleach?

(Sorry if this question is only partly biological) I have noticed that several cats (including the one that keeps sleeping in my house), are fond of the odor of bleach (eau de Javel) and chlorine. ...
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1answer
139 views

How can we measure cardiac output?

I could find a way which could find it by body oxygen consumption and there is another way to measure it by injecting drugs โ€” measuring cardiac output by the so-called โ€œindicator dilution method,โ€ a ...
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81 views

What's Incomplete atrioventricular heart block (AV)? [closed]

This is unclear for me and I can not understand differences between complete and incomplete atrioventricular heart block.also I want an electrocardiograph of incomplete atrioventricular heart block.
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1answer
113 views

Whatโ€™s the reason for isovolumic contraction and isovolumic relaxation?

During cardiac cycle, there are two periods in which the heart volume doesnโ€™t change, but there is a change in tension/pressure. It takes about 0.25-0.35 second to achieve this change. I searched in ...
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1answer
196 views

Relationship between nerves and axons

I just wanted to get a realistic viewpoint of our nervous system. I understand arteries and veins, but I wanted to know how similar our nervous system is to that? I understand we have neurons ...
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1answer
68 views

Biphasic T wave caused by digitalis toxicity

Digitalis is a drug that can be used during coronary insufficiency to increase the strength of cardiac muscle contraction. But when overdosages of digitalis are given, depolarization duration ...
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1answer
77 views

Why is pericardium muscle repolarizated earlier than endocardium? [closed]

I was reading about heat muscle contraction and I read: The endocardium depolarization happens earlier than pericardium , but pericarduim repolarization happens earlier, therefore the T wave in ...
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1answer
2k views

What are the units of Q10 (temperature sensitivity)?

$Q_{10}$ is the increase in a rate (e.g. activity of an enzyme) observed with a 10° temperature increase. According to Wikipedia: ...
2
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1answer
124 views

What happens to our umbilical cord internally as we age?

I was always curious as to if or how much of the internal structure or workings of the umbilical cord are still in existence as we age. What happens to it over time? The wikipedia article naval ...
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0answers
2k views

Why do we experience temperatures below 37 degrees Celsius as 'hot'? [duplicate]

We always prefer to be in 20-25ยฐ C, although our core temperature is about 37ยฐ? Why is our skin temperature lower than our core temperature?
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1answer
42 views

Why is the resting potential of a neuron so close to the equilibrium potential of Kโบ?

I know this has something to do with the K+ leak channel. I just don't understand how. I know that 3 Na+ are pumped out for every 2 K+ pumped in. This makes the cell interior net negative. I know ...
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3answers
138 views

Which fruit compounds affect the speed of fructose absorption?

Blood fructose levels are not regulated by insulin in the human body. This means that the body absorbs pure fructose very fast, and it raises the blood fructose levels rapidly. Do fruits/ vegetation ...
2
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2answers
179 views

Calcium levels and nerve hyperexcitation

Why does lower blood calcium levels (or lower calcium levels in ECF) cause nervous hyperexcitaton? Why does it cause over stimulation of nerves and muscles and spasmic contractions of muscles? This is ...
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1answer
72 views

What specific sensory nerves act as receptors for “pins and needles” (neuropathy)?

According to this excellent answer, the difference between "pain" and "pins and needles" (neuropathy) is that different receptors (sensory nerves) trigger in reaction to different stimuli. Different ...
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2answers
179 views

Why do skin and nail go blue in cyanosis?

I have learned that Cyanosis presents with blue skin and nails. What is the reason for the blue coloration of the skin and nails? Why wont the skin and nails turn another color in the visible spectrum ...
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3answers
257 views

How does vasoconstriction/vasodilation change blood pressure?

Background: I am coming at this question from an electrical engineering background, and I feel like I am missing certain assumptions that are going into the statement found in my physiology textbook, ...
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2answers
136 views

What is the name of the condition where no pacemaker cells are active in the heart for a short-time?

Assume that the heart is beating, but no pacemaker cells are working for at least 15 seconds. This would be a very long compensatory pause if extrasystole started it. There may be some low frequent ...
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2answers
114 views

Why can't we defibrillate the heart within 1 minute after ventricular fibrillation by electroshock?

We mostly can defibrillate the heart before 1 min of ventricular fibrillation by electroshock.Then we often can't do defibrillate it with electroshock. What's the reason and What's the best way to ...
3
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1answer
45 views

Why do the size of the phase 1 notch vary among cardiac cells?

The size of the phase 1 notch varies among cardiac cells. It is prominent in myocytes in the epicardial and midmyocardial regions of the left ventricular wall and in ventricular Purkinje fibers. ...
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1answer
128 views

Why do ion concentrations change with different secretion rates in pancreatic juice?

Why is it that when secretory rate increases in the pancreas the concentration of chloride ions decreases, and the concentration of bicarbonate increases in the production of isotonic NaCl secretion? ...
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1answer
231 views

Why doesn't HDL cause diseases like LDL? [duplicate]

LDL particles pose a risk for cardiovascular disease when they invade the endothelium and become oxidized, since the oxidized forms are more easily retained by the proteoglycans. A complex set of ...
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2answers
196 views

Why don't we see turbulence in the aorta even in normal situations?

I read about the Windkessel effect. Then I read about pulse pressure waves getting reflected from the periphery. If the pulse pressure wave is reflected during diastole and at the same time blood is ...
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1answer
193 views

Is a raised baseline between T and QRS normal in any ECG lead?

Here are excerpts from an unknown ECG lead. I find it weird that the "baseline" changes after the T wave and doesn't return until after the following QRS complex. Is that normal/expected for any lead? ...
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1answer
62 views

Does repolarization of muscle fibers mean that the muscle bundle is relaxed?

If I flex my bicep and continue to contract it does it mean that the muscle cells are in depolarizing state and not repolarizing?
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119 views

Can humans live without their right atrium?

The right atrium is one of four chambers (two atria and two ventricles) in the hearts of mammals (including humans) and archosaurs (which include birds and crocodilians). It receives deoxygenated ...
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1answer
82 views

Voltage-gated Potassium channels in the action potential of cardiomyocyte?

There is one type of potassium voltage-gated channels open in Phase 1 too. Some call them early repolarization channels. I am not convinced that the channels are different in different phases: 0, 2, ...
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4answers
81k views

What's the maximum and minimum temperature a human can survive?

This is a question that has been in my mind since I was a kid. I'm not a doctor, nor even a biology student, just a curious person. What is the minimum and maximum temperature a human body can stand ...
3
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2answers
174 views

What is atrial fibrillation? [closed]

I am wondering exactly what a-fib is (causes and symptoms). I would really appreciate having a sample of an EKG with it (because in my limited research, I have found it nearly impossible to find just ...