The tag has no wiki summary.

learn more… | top users | synonyms

0
votes
0answers
26 views

Interpreting Graph

I am studying evolutionary biology, and been presented with this graph: I am having some difficulties understand its meaning. For a start, why is time measured as a fraction of the population size? ...
5
votes
2answers
90 views

Simulating substitution rate of neutral mutations

I am trying to computationally simulate a population based on the Wright-Fisher model I would like to get to the classic result of the neutral theory of molecular evolution that the rate of neutral ...
2
votes
0answers
24 views

What is the allelic frequency at mutation-selection-drift equilibrium?

At mutation-selection equilibrium the expected frequency $f$ of a given locus is $$f ≈ \frac{\mu}{s\cdot h}$$ , where $\mu$ is the mutation rate, $s$ is the selection coefficient and $h$ is the ...
3
votes
2answers
153 views

Definition of “Effective population size”

Could you explain to me, what is the meaning of "Effective population size ($N_e$)"? I would appreciate an example as well.
6
votes
1answer
75 views

What does “Mutational Variance” mean?

Background The concept of mutational variance can be found in many articles including this one for example. The mutational variance of a trait number $i$ can be found in the M-matrix in position ...
2
votes
1answer
42 views

Heterozygosity and the Wright-Fisher model

I was reading the textbook Probability Models for DNA Sequence Evolution by Durrett. In chapter 1, he discusses the Wright Fisher model and the coalescent theory ...
6
votes
1answer
194 views

Microsatellite shifts (peak calling) GeneMapper! Thesis help!

I'm a masters student attempting to conduct a parentage analysis on a population of fish for my thesis. My advisor and post-docs haven't been very helpful, so I need some help! I have dinucleotide ...
5
votes
1answer
75 views

Why are recombination rates increasing in mammals?

I have recently become fascinated with an awesome topic in biology and evolution that I feel is rarely covered in biology courses. That is, rates of meiotic recombination, or the the amount that an ...
2
votes
2answers
52 views

Conservation Genetics - Book recommendations

Can you please give me some advice for a book in (evolutionary) conservation genetics that offers an in-depth review of the mathematical formulations used in this field. I read the book Evolutionary ...
1
vote
0answers
29 views

Effects on Bear Population [closed]

imagine in a given area or an ecosystem ,bear hunting is totally banned, but there is a scarcity of food for the bears. i want know what would be the future of the bear population?. and want to derive ...
1
vote
1answer
28 views

A question on exclusion of study participants for an Exome genotyping array

I'm reading a paper that used whole exome sequencing on an African American and European populations to discover novel low frequency and rare variants associated with lipid levels & the risk of ...
1
vote
1answer
25 views

Investigating rare variants in ethnically different populations (European ancestry & African ancestry)

If you are investigating low-frequency and rare variants for a complex trait using exome sequencing, why would one consider using different populations (African ancestry and European ancestry) ...
2
votes
0answers
87 views

Software to calculate Fst from sequence data

I'm looking for a software to calculate Fst from 3 loci DNA data of individuals from a metapopulation. I don't have any prior on the population structure (have no idea of the number of subpopulations ...
1
vote
1answer
30 views

Assumptions of the models for haploid and diploid selection

For a bi-allelic locus, the model for haploid Natural Selection is: $$\frac{dp}{dt} = \frac{pW_A}{pW_A + (1-p)W_B}$$ , where $p$ is the frequency of the allele $A$, which relative fitness is $W_A$. ...
2
votes
1answer
42 views

$F_{ST}$ when considering a multi-allelic locus

Sewall Wright defined the $F_{ST}$ in a metapopulation as being: $$F_{ST} = \frac{\text{Var}(p)}{\bar p (1-\bar p)}$$ , where $p$ is a vector of frequencies of a given allele and $\bar p$ and ...
7
votes
2answers
284 views

Help with the Price equation

The Price equation describes mathematically the evolution of a population of units from one generation to the next. $\bar{w}\Delta \bar{z}$ = $Cov (w_i,z_i) $+$ E(w_i\Delta z_i)$ I would like ...
1
vote
1answer
49 views

Various Genetic Loads and their Definitions

In population genetics, we talk about several types of genetic loads (also called just loads). I am asking for a exhaustive list and a short definition. Here are for example some genetic loads that ...
1
vote
0answers
25 views

Series of exercices on population structure (population genetics)

I am seeking for a series of exercices (with solutions if possible) concerning population structure. I am particularly interested in exercices that involve indices such as $F_{ST}$, $F_{IT}$, ...
1
vote
1answer
76 views

Coalescent theory - independence of coalescent times

Let $T_i$ be the time to coalesce from $n(t)=i+1$ to $n(t)=i$, where $n(t)$ is the number of sites that have not coalesced yet. In the below example the maximum $n(0)=6$. As I understand it, many ...
2
votes
1answer
54 views

Coefficient of relationship and path of coefficient

A path of coefficient of relationship is defined as $$\rho_{AO} = \left( \frac{1}{2}\right)^n \sqrt { \frac{1+f_A}{1+f_O}}$$ This SE post discusses this definition From this, the coefficient of ...
2
votes
0answers
42 views

Inbreeding Coefficient and Coefficient of Relationship

Wikipedia gives the following formula to calculate a "path of coefficient of relationship" between an ancestor $A$ and an offspring $O$: $$\rho_{AO} = 2^{-n} \left( \frac{1+f_A}{1+f_O} \right)^{1/2} ...
0
votes
1answer
54 views

Defining: Evolutionary (quantitative) Genetics and Population Genetics

How do we define the fields that are Evolutionary (quantitative) genetics and population genetics. What set these two fields apart? Can you try to provide definitions? To my intuitive understanding, ...
0
votes
1answer
34 views

Metapopulation structure - book recommendations

What book would you recommend me to study: the dynamics of metapopulations, the structure of metapopulations, the evolution in structured metapopulations? I am not looking for an introduction ...
2
votes
1answer
40 views

Definition of Linkage Desiquilibrium (LD)

According to wiki, linkage disequilibrium $D$ equals $$D = x_{11} - p_1\cdot q_1$$ where: $$ \begin{matrix} \text{Haplotype} & \text{Frequency}\\ A_1B_1 & x_{11}\\ ...
2
votes
1answer
132 views

How to interpret the breeders equation?

The univariate breeders equation is defined as, $\ R = h^2 s$ where $\ R $ is the response, $\ h^2 $ is the heritability (additive genetic variation), $\ s $ is the selection differential. The ...
1
vote
1answer
133 views

Heterozygosity and overdominance

Consider $m$ loci with heterozygote advantage (overdominance) such that the fitness of the two homozygotes is $1-\frac{s}{2}$ and the fitness of the heterozygotes is $1+\frac{s}{2}$, where $s>0$. ...
1
vote
1answer
31 views

Coalescent Theory - Probability for $k$ alleles that of one coalescence event occured $t+1$ generations ago

From this textbook Under the wright-Fisher model of genetic drift and under the assumption that all alleles are neutral, the probability that $k$ alleles had $k$ distinct parent alleles the previous ...
9
votes
3answers
250 views

Book recommendation on population/evolutionary genetics?

I have recently been involved in collaborations that require me to model the population genetics of eukaryotic populations. I fear I may either be "re-inventing the wheel" or making conceptual ...
1
vote
1answer
64 views

Population Genetics Question

Can someone please help with this question? Here is my working (just in case it is not clear: 1/300*1/30*1/2) but is this actually correct or do I need to multiply by 0.5 once again? I appreciate ...
3
votes
2answers
464 views

Initial population when i count backwards?

My question is dealing with how many ancestors it took to produce me: --> to produce me it took 2 people (my parents) = ($2^1$) people = 2 --> one generation further included = ($2^1 + 2^2$) people ...
0
votes
1answer
32 views

Quantitative Traits Genetics

Can someone please help with this question? I'm not so sure whether part A should be 11 inches or something else. Also, is part B correct
2
votes
1answer
54 views

Effective population size when the population sizes varies from season to season

Let's think of a species which has four generations per year and which population size changes from season to season so that the population size is 100 in summer, 200 in spring, 50 in autumn and 20 in ...