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21
votes
1answer
315 views

Phagemid display

If I'm using a bacteriophage for phage display and I'm trying to avoid avidity effects by using a helper phage what would be the best way to maintain a large library size while keeping everything ...
10
votes
2answers
1k views

What is the evolutionary reason behind the fragility of teeth?

Almost all organs in the human body have a rather large threshold within which the organ or tissue is capable of repairing itself using materials supplied by the body, whether it's made from organic ...
7
votes
1answer
239 views

What preceded ATP synthase?

ATP Synthase is ubiquitous throughout life on earth and so most probably evolved within the last universal common ancestor (LUCA) before that lineage diversified into the various kingdoms of life. ...
5
votes
5answers
143 views

What are some examples of evolving networks in biology?

I'm a master student working on networks analysis in general. A network is something that has nodes and there are links between the nodes. Nodes and links could have attributes. An evolving network is ...
5
votes
1answer
43 views

Is there any evidence telling us what the oxidation state of early earth's atmosphere was?

I ask this question in relation to the origin of life. I realise it would probably be better suited to a geology stack exchange, but it does not yet exist. The Miller-Urey experiment gives a lab ...
3
votes
1answer
432 views

Ka/Ks (dN/dS) analysis module for Python?

From this wiki article: In genetics, the Ka/Ks ratio (or ω, dN/dS), is the ratio of the number of Nonsynonymous substitutions per non-synonymous site (Ka) to the number of synonymous ...
2
votes
1answer
51 views

Preserved alpha complementation over evolutionary time?

Has the result of alpha-complementation ever happened via mutation through evolutionary time, and been preserved in modern day organisms? In other words, has a functional gene product ever been split ...
2
votes
1answer
29 views

Evolutionary rationale behind migration proteins

Tumor cells are able to migrate due to specific migration proteins. What is their evolutionary origin? Or are they simply deregulated?
1
vote
2answers
86 views

what does sequences overlap indicate

what does it mean if different protein sequences overlap upon multiple alignment, are they the same, do they have a common ancestor, are they recombinants of each other and how does one go on to ...
1
vote
0answers
16 views

histamine inter-cellular and cytoplasmic binding site

I noticed that HRH (histamine receptor) has an inter-cellular and cytoplasmic binding site of anti-histamines which are equal in binding energy. Does anyone know what is the function of the well ...
-1
votes
3answers
151 views

A question regarding evolution

I'm not a biologist so bear with me. I know that the DNA molecule carries extremely large amounts of information. If the process of evolution is driven by completely random process .I think about it ...