Tagged Questions

Quantitative genetics is the study of inheritance at the phenotypic level.

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3
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1answer
29 views

Effect of recombination on the rate of loss of genetic variation

Following up from this question: Does recombination increase the additive genetic variance for fitness? (I'm thinking about the evolution of additive genetic variance and differences between the sex ...
3
votes
0answers
18 views

Mechanisms of Gene*sex / Genotype*sex interactions

I'm looking for suggestions of the mechanistic level at which genotype/gene * sex interactions can occur. These give different phenotypes from the same geneotype dependent on the sex they are ...
2
votes
1answer
42 views

(Updated question) Problem with Fold-change mean compared to absolute data (in qPCR)

For the problem below I am aware of the statistics involved but just can't get my finger around the following: In biology we use qPCR to measure gene expression or basically number of mRNA copies. It ...
3
votes
0answers
24 views

More extreme phenotypes when parents are from diverged populations

In quantitative traits we have many loci affecting a trait. If we took a bunch of parents where all mothers and fathers were of a certain value at the upper end of a trait range, and then looked at ...
1
vote
0answers
20 views

How many traits can a multivariate breeders equation handle?

The multivariate breeders equation (MBE) by Lande predicts the change in a trait $\Delta \bar z$ (response) as $\Delta \bar z = G \beta$ where $G$ is a genetic variance-covariance matrix and ...
6
votes
0answers
102 views

Calculating additive variance, heritability, and percent of variance explained by additive effects

I've set up some dummy data in R which makes 40 genetically related lines (in this case I'm simulating hemiclones - they share one haploid copy of there genome within a line, thus additive genetic ...
3
votes
0answers
52 views

How does Natural Selection shape Genetic Variation?

Background Importance of the additive genetic variance As stated here, the fundamental theorem of Natural Selection (NS) by Fisher says: The rate of increase in the mean fitness of any organism ...
3
votes
1answer
33 views

Loss of allelic variation per generation of full-sib mating

If we take a male and female, cross them, and collect one son and one daughter to produce the next generation (and continually do this for many generations) - (full-sib mating design) how much genetic ...
3
votes
1answer
296 views

What is needed for a G-matrix?

I have been doing a lot of reading on quantitative genetics and the G- (and B-) matrix lately. I get the principle behind performing the analysis now but I am still not sure how to do it. I'd like to ...