A receptor is a molecular target for a chemical signal such as a neurotransmitter, hormone, or drug. Binding of the signal to the receptor initiates or modulates behaviour in the receiving cell.

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What is the essence of difference of how different chemicals affect the same receptor?

It is known that various chemicals can bind to the same receptor type, producing different effects. Be these chemicals agonists or antagonists, there are more variations in how they influence the ...
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Are all Autoreceptors Downregulated by their Respective Endogenous Ligands?

I know that the 5-HT1A and $\alpha$2 adrenoreceptors receptors serve as autoreceptors for serotonin (5-HT) and norepinephrine respectively and are down-regulated by repeat exposure to their respective ...
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RAGE Oligomerization and Signalling Mechanism

I am looking to understand the mechanism of how the advanced glycation end products, s100 proteins and B-amyloids interact through oligomerization with the RAGE molecule (AGE receptor). I would also ...
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If a receptor is inhibited throughout embryogenesis, could there be observable phenotypic differences in the adult?

So I read a journal article entitled "Maternal hypoxia and caffeine exposure depress fetal CV function during primary organogenesis" (Momoi, et al., 2012) and in essence the article speaks of the ...
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Dopamine receptor count: Role and Measurement

Can the Dopamine (DA) receptor count take a significant drop over the course of life or does it stay constant? I read that low D2 (Dopamine receptor type 2) receptor count does not cause Parkinson's ...
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66 views

Which of the three is true for insulin receptors?

I have seen the following question in a Cell Biology exam: Which of the following is true" Insulin has an hydrophobic Signal Peptide and the insulin receptor does not have an hydrophobic ...
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What is the lifetime of the vasopressin receptor V2?

I was looking at the production of vasopressin receptor 2, also known as V2R or ADH-R. What I found is that it is coded by the AVPR2 gene and degraded by the Alix protein (source). But I did not get ...
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55 views

Isotretinoin and retinoid receptors in brain confusion?

I am considering starting a treatment with Accutane(Isotretinoin), however I am not sure about what the effects on the brain are. Here are two studies that contradict each other: http://www.ncbi.nlm....
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Why is there only adrenoreceptors and no active adrenergic innervation in bronchus and uterus?

Our bronchus and uterus has beta adrenoreceptors, but they have no active sympathetic nervous system innervation in these organs. Was there a sympathetic innervation in trachea and uterus, earlier, ...
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24 views

Which classes of drugs (filed by their pharmacology) induce a release of β-endorphin?

Which classes of drugs (filed by their binding sites) induce a release of β-endorphin? I know of agonists of the nAChRs and 5-HT1A and ethanol. Are there any others? Please cite journal articles ...
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Does regulate always mean suppress when it comes to heteroreceptors?

Do heteroreceptors always suppress the release of the neurotransmitter they regulate upon their (the heteroreceptor's) activation?