The process of breaking and recombining strands of DNA.

learn more… | top users | synonyms

0
votes
2answers
52 views

Why does meiotic recombination disrupt the independent assortment of genes on the same chromosome?

There are many sources that say that genes that are "linked" by being on the same chromosome assort with each other -- that when an allele is passed on that the gamete containing said allele will also ...
0
votes
0answers
12 views

VDJ recombination in non immune cells

Is VDJ recombination active in non immune cells? If not then what is the mechanism that triggers it in immune cells but not in other cells?
1
vote
1answer
48 views

Data on Recombination rate and Gene Positions in Humans

I am looking for estimates of per base pair recombination rate in humans and indication on gene positions. The goal is to be a able to plot recombination rate in the y-axis and position (in bp) along ...
6
votes
4answers
13k views

What's a non-allelic gene?

Non-allelic or non-alletic I stumbled across the term in my Human Genetics textbook. It didn't explain it there, and a quick google search only showed scientific papers that refer to 'recombinations ...
4
votes
1answer
810 views

Genetic linkage greater than 50 centimorgans

Classically, the linkage between two loci can be measured in centimorgans (cM), which represents the percent chance that these two loci will recombine an odd number of times (generating a recombinant ...
0
votes
0answers
3 views

Steps between Expression & Commercialization of a recombinant organism

What are typical steps that follow after one has successfully expressed a hetrologous gene in a host organism before one has a viable industrial process for the metabolite expressed? Let's take E ...
2
votes
2answers
277 views

Why asexual reproduction?

When I took a course on genetics and evolution, I learned that recombination and sexual reproduction is advantageous compared to asexual reproduction. Sexual reproduction allows more combinations of ...
8
votes
4answers
902 views

Mitochondrial DNA and recombination

Firstly I could do with a brief description of mitochondrial DNA. How does the structure of DNA in mitochondria compare to animal DNA (for the sake of simplicity let's say human - some animals might ...
2
votes
1answer
1k views

recombination frequency problem

Three loci C, D and E are located on the same chromosome in this order. We found that the frequency of recombinants between C and D is 10% and that between D and E it is 20%. Assuming that ...
0
votes
1answer
688 views

Possible Genotypes — Linked Genes

Please consider the following question: Genes A and B are located on the same chromosome. If two individuals with the genotype shown below are crossed, which genotype could be formed? Let / ...
4
votes
1answer
166 views

What is the difference between conditional and inducible activation?

In the modern genetically modified animal models, there are not only constitutive mutations which start producing proteins already in the embryo, but also mutations which can be turned on later. I've ...
0
votes
0answers
7 views

Is there sex specific recombination data from the HapMap project?

I am looking at the recombination data the HapMap project makes available. I noticed that despite the fact that recombination occurs more frequently in females, the only data releases available that I ...
2
votes
1answer
195 views

Which process is right to describe V(D)J recombination? RAG-1 and RSS recurring process

I'm studying V(D)J recombination. I think I have two incompatible books about explantaion of the process. Which is right? In Molecular Biology of the Cell 5th Ed., firstly RAG (-1?) combines to RSSs ...
1
vote
1answer
67 views

meaning of “usually greater than 200 base pairs”

From "Risks from GMOs due to Horizontal Gene Transfer", by Paul Keese: Homologous recombination. All cellular organisms have molecular functions dedicated to recognizing and recombining DNA ...
1
vote
0answers
51 views

Calculating the recombination factor of four point genetic cross?

So, I'm trying to work out the recombination factor (RF) from this set of data: Which shows the 16 phenotypes of progeny of a cross of Saccharomyces cerevisiae yeast. I know how to go about a three ...
1
vote
1answer
99 views

Recombination fraction( frequency) in Homozygotes

I have a question about the recombination frequency I hope you have time to answer. Background: If we look at homozygous individual A/A B/B which has been formed from the gametes AB and AB, this ...
1
vote
1answer
45 views

How do I find the sequence of the phage BxB1 gene?

Specifically, I'm trying to find the sequence of BxB1 and its att sites. I have success finding the att site sequences, but I'm having a bit more of an issue with finding the sequence of the actual ...
5
votes
1answer
248 views

Mitotic crossover happens in G1?

I was reading this article in wikipedia and came across this : It has been suggested that recombination takes place during G1, when the DNA is in its 2-strand phase, and replicated during DNA ...
5
votes
1answer
393 views

Understanding recombination scoring in family pedigrees

I am having some problems understanding recombination, and I am not sure what element I am missing here. This figure is an example from my text book. The pedigree belongs to a family with an autosomal ...
1
vote
1answer
103 views

How long the homologous arms of the “repair” sequence must be to do homologous recombination? [duplicate]

I am trying to figure out the details of the homolougous recombination in order to be able to insert a certain piece of DNA in the host genome after double strand break.. Does anybody know how long ...
2
votes
1answer
32 views

What mechanisms exist for the excision of specific sequences from DNA?

I already know about recombinases (specifically excisionases), but was wondering if there were other mechanisms present.
1
vote
0answers
38 views

Is recombination suppressed in the males of all Drosophila species? Any other species?

Following up from this question, I am wondering if the phenomenon of genome-wide suppressed male recombination is limited to Drosophila melanogaster or is common to all Drosophila? The answer to the ...
0
votes
1answer
39 views

Breaking a gene during recombination

I just started reading about recombination frequencies of genes and related stuff, and can't find an answer to this (possibly naive) question. Can recombination possibly "kill off" a gene ? To be ...
2
votes
1answer
82 views

Why does the stability of YAC increase with size?

From Lehninger Principles of Biochemistry : The stability of YAC increases with size (up to a limit). Those with inserts of less than 100000 are gradually lost during mitosis. Why does this ...
4
votes
1answer
95 views

Effect of recombination on the rate of loss of genetic variation

Following up from this question: Does recombination increase the additive genetic variance for fitness? (I'm thinking about the evolution of additive genetic variance and differences between the sex ...
1
vote
0answers
25 views

Recombination frequency as a function of genomic location in E coli?

Are there any databases or papers that give recombination frequency as a function of position in the E coli genome?
6
votes
1answer
159 views

Hill-Roberston effects and effective population size

From this article, first page, middle of the second column: Even if harmful alleles do not become fixed, they can still reduce the efficacy of selection on neighbouring loci through a process ...
7
votes
1answer
150 views

Why are recombination rates increasing in mammals?

I have recently become fascinated with an awesome topic in biology and evolution that I feel is rarely covered in biology courses. That is, rates of meiotic recombination, or the the amount that an ...
3
votes
0answers
179 views

A Genetic linkage problem [closed]

I have recently switched from electronics to computational biology. So having some hard time with my homeworks. Can someone guide me on this problem? Consider 6 genes A, B, C, D, E, F, G. Some ...
2
votes
2answers
1k views

How many recombination events are there per generation in humans?

I'm looking for a reference that tells me how many recombenation events occur in humans from one generation to the next. Assuming that the human genome is a 3.3 GigaBases long DNA sequence, how many ...
1
vote
0answers
39 views

Study case of the inheritance system of Oenothera

I've been told some interesting facts about oenothera. Apparently in this species some lineages have been through some translocations and in results to these translocations and in consequence, some ...
2
votes
1answer
108 views

Size of DNA in phage

I have read that DNA(after recombination) is packaged in bacteriophages lambda only if it's between 40000 and 53000 bp long. This constraint can be used to ensure packaging of recombinant DNA. I don'...
2
votes
1answer
194 views

Does recombination increase the additive genetic variance for fitness?

On this article, first column, eighth line of the introduction: By bringing together favourable alleles from different chromosomes, sex and recombination increase the additive genetic variance for ...
9
votes
3answers
9k views

Why doesn't recombination occur in male Drosophila?

"Males do not show meiotic recombination, facilitating genetic studies." For a while I have known that this phenomenon occurs, this quote comes from the Wikipedia page on Drosophila melanogaster, ...
1
vote
1answer
31 views

Could mating/recombination be responsible for evolution of entirely novel features?

The diploid chromosomal architecture is rather interesting. For example, because of diploidy we Humans have to mate. Of course in that sense, because diploid organisms often have mate, this has led to ...
3
votes
1answer
49 views

What is the genetic distance where linkage can be ignored?

I heard several times that two SNPs, that have at least 1'000 nucleotides between them, can be seen as 'unlinked' due to frequent recombination events. I also once saw a paper showing a graph "degree ...
2
votes
1answer
331 views

How does electroporation mediated recombination work?

For yeast and other organisms, DNA can be readily taken up into the cell naturally or through membrane disruption. What does applying a voltage to cells do exactly that allows more recombination to ...
0
votes
2answers
86 views

What is a “tool strain”?

When a biologist is talking about a genetically engineered mouse strain which is a "tool strain", what does that mean? What is the exact definition of a tool strain? What is the difference between a ...