Retroviruses are single-stranded RNA viruses that reverse-transcribe their genome into DNA that is then integrated into the host genome.

learn more… | top users | synonyms

4
votes
1answer
220 views

Why AZT is selective towards HIV and doesn't impair human DNA replication?

I've found this article, which is a very old one (from the time when nucleoside analogs where researched as a possible way to prevent replication of virus genetic material, before the HIV epidemics). ...
1
vote
4answers
44 views

How does HIV mutate into other strains while keeping their virulent phenotype?

How does a virus like HIV mutate into so many strains, and yet all of them are harmful to our immune system? What gives this virus the ability to mutate so efficiently?
3
votes
1answer
38 views

Are some virus loads introduced to human cell but never triggered?

Is there a term or any evidence of phage DNA integrating into chromosomes/ DNA but never being triggered? For example, could a virus that affected Neanderthals still infect human cells today but is ...
2
votes
1answer
109 views

Are retroviruses cytotoxic?

There are typically hundreds of retroviruses found in healthy human beings. Are retroviruses then cytotoxic? (In other words, are they able to kill or damage other cells).
9
votes
5answers
404 views

Is there an 'anti-virus'?

A virus spreads around and usually attaches itself to the host, multiplies & causes diseases. But is there something like an anti-virus? A single celled entity that does the opposite: spreads ...
2
votes
1answer
270 views

Is it impossible for a retrovirus to be lysogenic?

Is it impossible for retroviruses to be lysogenic? In the lysogenic cycle, the viral genetic material is incorporated into the host cell's DNA. Because retroviruses have RNA, it would be impossible ...
2
votes
1answer
89 views

Mutation rate in viruses

Mutation rate is a phenotypic trait that evolves. The process of evolution of such kind of traits are often referred to as evolvability. I am wondering about the evolution of the mutation rates in ...
1
vote
1answer
85 views

Why use DNA polymerase in making cDNA?

RT is capable of synthesizing a complementary dna strand ( as in HIV life cycle.) Then why is DNA pol used when cDNA (synthesizing the second strand of it ) has to be synthesized from mRNA ( For eg.to ...
3
votes
2answers
428 views

How is RNA of retrovirus converted into cDNA?

The retrovirus (oncovirus) contains RNA. It also has a molecule called reverse transcriptase. This molecule transcribes RNA into cDNA. This cDNA is the DNA copy of viral RNA genome RNA has Uracil ...
2
votes
2answers
136 views

Can retroviral delivery systems “overwrite” genes?

As the question states, what are the limits of retroviral genetic delivery systems? Are they limited to adding additional gene sequences to a cell, or can they actually overwrite specified segments ...