2
votes
1answer
127 views

What are the effects of combining rapamycin with dietary restriction?

Are the effects additive or subadditive? In many ways, rapamycin acts like a CR mimetic, but even CR can only go so far.
5
votes
1answer
99 views

In what ways, if any, does administration of rapamycin *not* mimic calorie restriction?

Numerous sources like this say that rapamycin increases lifespan. And mTOR antagonism appears to be a large part of this (mTOR antagonism also appears to be a large part of calorie restriction's ...
10
votes
3answers
200 views

Does current evidence support the use of resveratrol as an anti-ageing drug?

A while back there was a lot of noise about resveratrol, a naturally occurring phenol which was touted as a potential anti-aging drug due to its role in regulating the SIRT 1 gene. A number of studies ...