The process of biological aging or the state of an organism being biologically old.

learn more… | top users | synonyms (2)

6
votes
1answer
649 views

Exercise causes number of cell divisions to approach Hayflick limit faster? And hence shorten life expectancy?

A world class athlete spends a lot of time performing intense exercises. Correct me if I'm wrong, but I assume that these intense exercises causes significant damage to the athlete's cells, but with ...
14
votes
4answers
2k views

Why is the Hydra Biologically Immortal?

I have heard that the Hydra organism is biologically immortal (later I found that there are more immortal organisms). Now I know that its immortality is related to its telomerase. The thing is that we ...
3
votes
0answers
82 views

Papers linking telomeres and aging [closed]

I'm currently writing a piece of work about telomeres and aging, and wondered if you could share some good papers you've either read or know of.
4
votes
1answer
197 views

Is cell senescence in culture comparable to that in vivo?

A cell is 'senescent' when is has permanently left the cell-cycle. This can be caused by stresses, or by reaching the 'Hayflick limit' (the cell has reached its replicative lifespan, as defined by its ...
3
votes
2answers
240 views

Does the speed of electrical impulses through neurones decrease with age?

From what I read on the NatGeo app, it stated that the speed of the electrical impulses that are sent by a neurone will be approximately 332 kilometers per hour. Will the speed of this electrical ...
8
votes
1answer
3k views

How does the NAD+/NADH ratio affect lifespan in vertebrates?

Here's the proximate physical implication of the ratio (from the Wikipedia article on NADH). The balance between the oxidized and reduced forms of nicotinamide adenine dinucleotide is called the ...
5
votes
1answer
82 views

Why would we overexpress Sir2 by overexpressing its hypomorph (dSir2-EP2300) in C. elegans?

Can't we just overexpress regular Sir2 in the paper? Rather than overexpress a reduced-function gene? The paper is Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, ...
2
votes
1answer
66 views

Age-associated neurodegenerative diseases

Age-associated neurodegenerative diseases encompass Alzheimer's Disease and Parkinson's Disease. What other neurodegenerative diseases could be described as age-associated? Multiple Sclerosis? Brain ...
4
votes
1answer
83 views

During human ageing, which immune cell sub-types are most affected?

It is now well established that human ageing is accompanied by an increase in systemic, low-grade (chronic) inflammation, sometimes termed inflammaging (Franceschi, 2007). This is in part due to more ...
11
votes
3answers
221 views

Does current evidence support the use of resveratrol as an anti-ageing drug?

A while back there was a lot of noise about resveratrol, a naturally occurring phenol which was touted as a potential anti-aging drug due to its role in regulating the SIRT 1 gene. A number of studies ...
7
votes
3answers
123 views

Free Radicals for aging

From my understanding free radicals play a slight role in ageing. In what ways are they so damaging, and can a restricted diet reduce production of free radicals?
3
votes
1answer
449 views

Could inhibition of progerin formation slow the rate at which a body ages?

According to wikipedia, progerin is activated in senescent cells. The protein itself is known to be the cause of a rare affliction 'progeria' - a disease marked by accelerated aging of the body. This ...
12
votes
1answer
238 views

Have any mutations or genetic loci been associated with exceptional longevity in humans?

Individuals that avoid age-related diseases into later life are known as 'exceptional survivors', and have increased longevity compared to their 'controls' (those that were born at a similar time, yet ...
5
votes
1answer
100 views

In what ways, if any, does administration of rapamycin *not* mimic calorie restriction?

Numerous sources like this say that rapamycin increases lifespan. And mTOR antagonism appears to be a large part of this (mTOR antagonism also appears to be a large part of calorie restriction's ...
0
votes
1answer
80 views

If inhibiting S6 kinase decreases protein translation, then could inhibiting S6 kinase could possibly slow down long-term potentiation in neurons?

From http://en.wikipedia.org/wiki/P70S6_kinase... Phosphorylation of S6 induces protein synthesis at the ribosome. P70S6 kinase is in a signaling pathway that includes mTOR (the mammalian ...
5
votes
1answer
235 views

Why isn't the p16-INK4a gene involved in apoptosis expressed in heart or liver tissues?

New York Times article explains how killing p16-INK4a positive senescent cells can help keep the surrounding cells vigorous. So here's my question: why is p16-INK4a expressed in most cells other than ...
2
votes
1answer
135 views

What are the effects of combining rapamycin with dietary restriction?

Are the effects additive or subadditive? In many ways, rapamycin acts like a CR mimetic, but even CR can only go so far.
6
votes
1answer
415 views

Why are beta-galactosidase proteins overexpressed in senescent cells?

Wikipedia explains that it's a hypothetical hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides only in senescent cells. I'm just wondering - what causes it to be ...
4
votes
1answer
1k views

How do caspase proteins kill a cell?

Wikipedia just says... The active effector caspases then proteolytically degrade a host of intracellular proteins to carry out the cell death program. Okay, but what parts of the cell do they ...
5
votes
1answer
150 views

Does AMP/ATP ratio affect lifespan in vertebrates?

The reference below says that a higher AMP/ATP ratio is associated with lower lifespan in C. elegans. Is this finding also generalizable to vertebrates as well? Reference: Apfeld, J., O’Connor, ...
16
votes
1answer
341 views

Why does regular exercise increase brain volume?

It has been shown in several studies that regular aerobic exercise increases brain volume in aging humans. The changes were observed in hippocampus and were correlated with dramatic reduction of ...