The process of biological aging or the state of an organism being biologically old.

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61 views

Telomere elongation methods?

What sort of telomere elongation methods are there currently? Would this stop aging? (edit: No, probably) I couldn't turn up anything good on google. I was thinking that maybe you could sequence ...
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130 views

What are the effects of combining rapamycin with dietary restriction?

Are the effects additive or subadditive? In many ways, rapamycin acts like a CR mimetic, but even CR can only go so far.
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25 views

How can stem cells be counted in body?

In the study of supercentenarian woman here, it was found that all her blood cells are formed from only two stem cells (ancestor stem cells). How scientists can distinguish cell ancestors? Aren't ...
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26 views

Source of information on the evolution of aging/senescence

Do you know a good review (published peer-reviewed or an online course or whatever) that offers a good overview of all hypothesis explaining the various patterns linked with aging? I'd like this ...
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66 views

In what ways can mechanisms of apoptosis be damaged?

How many ways can an Apoptosis mechanism be made disfunctional or irreparably damaged? If a cell has damaged Apoptosis mechanisms and it divides will its daughter cells have such damage?
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74 views

Does DNA influence death (e.g. by cell aging)

I know that we age because of errors in the cell replication process and these errors eventually leads to death. If we exclude environmental factors, are there any other factors that can cause these ...
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26 views

FoxO gene(s) and aging [closed]

How does the FoxO gene affect aging? I read about how Hydra uses the FoxO gene to live (practically) forever... How does FoxO gene work? Currently, all I know is FoxO regulates the stem cell ...
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63 views

What is the name of systemic tension of muscles?

I meat a overtrained friend (25 years old) who cannot rest. He has all muscles and most of the skin very tense. He is practising regularly in gym and sleep badly. He moves like a stick figure and has ...
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138 views

How is it that the WI-38 cell line isolated by Hayflick in 1962 is still very much around and not affected by the 'Hayflick Limit'?

I have searched the net and I have not been able to come up with an clear answer. Edit: Here is the para quoted from Nature http://www.nature.com/news/medical-research-cell-division-1.13273 "So began ...
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79 views

If inhibiting S6 kinase decreases protein translation, then could inhibiting S6 kinase could possibly slow down long-term potentiation in neurons?

From http://en.wikipedia.org/wiki/P70S6_kinase... Phosphorylation of S6 induces protein synthesis at the ribosome. P70S6 kinase is in a signaling pathway that includes mTOR (the mammalian ...
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33 views

How does the body repair extracellular damage caused by glucose?

So we know that glucose is an aldehyde that can cause cell damage to the lysine and arginine residues on proteins through the Maillard Reaction (among other damaging reactions that glucose ...
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40 views

Fibrinous inflammation, exudate and scarring in monotonous movements and ageing

I have palpated many hard organs during my work and studies. I have seen many young and old people who have hard organs, like very hard shoulder - very common. I have interviewed some of them, some ...
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Can we define biological age? [duplicate]

How can we define ageing from a biological standpoint without making an appeal to chronological age? Related, but less important, are there any metrics we can use to determine someone's biological ...