How well supported is the hypothesis that aging is mainly caused by the number of mutations in tissues?
I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is. Is this true? And how well ...
RHEB senses amino acids in order to recruit mTOR. Do we know if RHEB is more sensitive to some amino acids (like methionine) than other amino acids?
See http://www.ncbi.nlm.nih.gov/pubmed/21157483 for the full paper describing the process of how RHEB recruits mTOR. We also discussed this in Matt Kaeberlein's class yesterday and I posed this ...
How can we define ageing from a biological standpoint without making an appeal to chronological age? Related, but less important, are there any metrics we can use to determine someone's biological ...