The modeling of biological processes using the tools of applied mathematics
4
votes
1answer
106 views
Is local equilibrium a reasonable assumption for evolutionary processes?
Whenever I look at discussions of fitness landscapes (in particular, Kauffman's NK model) the questions tend to resemble:
The population is at a local equilibrium, but another equilibrium of ...
3
votes
1answer
59 views
Are there natural selection experiments that quantitatively agree with theoretical modeling?
Has anyone ever conducted an evolution experiment and quantitatively compared it to theory? For example, has anyone ever put bacteria in a million petri dishes filled with antibiotics and calculated ...
3
votes
1answer
52 views
When does weak selection produce qualitatively different results from strong selection?
In evolutionary game theory, it is typical to model organisms as having a base fitness that is modified slightly by the game interaction. The ratio of the game effect versus the base fitness ...
3
votes
0answers
38 views
Structure of fitness landscapes in the NK model
The NK model of rugged fitness landscapes consists of $N$ sites where fitness contribution of each site depends on its state $\{0,1\}$ and is epistatically affected by $K$ other sites. When defining ...
2
votes
0answers
40 views
Experimental techniques to measure protein-protein and protein-ligand structure and dynamics
We would like to compare our simulation results with experimentation. When one wants to follow experimentally the dynamics (and possibly structure) of protein-protein or protein-ligand docking ...
0
votes
0answers
14 views
Have there been any mechanisms proposed for normalization in probabilistic population codes?
I heard a talk recently by Dora Angelaki about multi-sensory integration. Part of the talk was about bayesian inference with multiple noisy sources of information. I know that there has been a lot of ...
