Tuberculosis is a disease caused by the bacterium Mycobacterium tuberculosis. It infects mainly the lungs, but can be found in other parts of the body. Untreated tuberculosis ends fatal.

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What (if anything) about tuberculosis makes producing a highly effective vaccine difficult?

What about tuberculosis makes it difficult to produce a safe vaccine that is effective at producing an immunogenic response in >99% of individuals against all strains of the bacteria? I am aware of ...
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TB disease - treatment and infection

Background: I'm currently performing research in mathematical biology, specifically on the treatment dynamics of HIV and TB co-infection. Question: Can a person infected with TB disease, who are ...
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Why PPD test in patients without M.tuberculosis often slightly positive?

I got this question which I interpret as Why PPD test in patients without M. tuberculosis often have slightly positive PPD reaction i.e., a lifelong slightly positive skin test reaction? because ...
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Why HIV patients have greater virulence of M.tuberculosis?

I am reading Murray Microbiology book. Some facts M. tuberculosis is an intracellular pathogen. At the time of exposure, M. tuberculosis enters the respiratory airways and infectious particles ...
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What are the characteristic structures of bacillus M. tuberculosis and what they cause?

I answered to this question: In most forms of the disease, the bacillus M. tuberculosis spreads slowly and widely in the lungs, causing the formation of hard nodules (tubercles) in the ...
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Can acid-fast M. tubercolosis obstruct alveoli?

I am not sure which word is the best here for colonisation of alveoli by acid fast-mycobacteria. I found this question, and I am getting confused by the term obstruction of alveoli because I tend to ...