2
votes
1answer
57 views

What are the requirements for a spectrometer to be used in biological research?

Suppose one would do spectrophotometry on biological materials. What would be the minimum requirements for the measuring device so that the results could be published in a reputable journal? I suppose ...
2
votes
2answers
123 views

To get Standard ECG from PhysioNet?

I am trying to get standard ECG by using PhysioNet's ATM with parameters but I get It should be something like How can you get complete standard 12-lead ECG out of Physionet database?
2
votes
1answer
68 views

How was Restriction Site of EcoRI sequenced?

The sequence of restriction site of EcoRI - GAATTC was identified in the early 1970s, before Sanger Sequencing was invented.(1977) How was the restriction site of EcoRI sequenced ?
2
votes
3answers
263 views

Why cancer mutations do accumulate sequentially?

According to Knudson hypothesis, cancer mutations accumulate in order. Statistics says, that cancer probability increases as sixth order of age, which may mean six consequential steps to cancer. But, ...
2
votes
1answer
152 views

What is the cause of dry cough?

I first thought this question in the case of the cause of dry throat after 3-day recovery of dry cough? but then I realised that the cause of dry cough can be a general thing. Assume the person ...
2
votes
0answers
47 views

Inbreeding Coefficient and Coefficient of Relationship

Wikipedia gives the following formula to calculate a "path of coefficient of relationship" between an ancestor $A$ and an offspring $O$: $$\rho_{AO} = 2^{-n} \left( \frac{1+f_A}{1+f_O} \right)^{1/2} ...
2
votes
2answers
448 views

How did the first sexual animal come to exist? [closed]

I am more or less familiar with the evolution theory based on mutations. Now, starting with a nonsexual being, how did the first organism that reproduces sexually come to exist.
2
votes
1answer
78 views

How many different smells can a human recognize?

How many different smells can a human recognize? If the space of smells is not discrete, how many dimensions it has (for example, the space of colors is three-dimensional).
2
votes
1answer
71 views

What happens during a Raynauds episode?

Raynaud's phenomenon can be a serious health issue, as the blood flow to the extremities, mainly the fingers is compromised, causing fingers to blanche, and then turn blue. Severe Raynaud's can cause ...
2
votes
3answers
144 views

Why are things conscious?

I've been referred to here from http://philosophy.stackexchange.com/questions/8052/why-are-things-conscious. Could you guys help out? Here's the question: What is the reason for animals or more ...
2
votes
1answer
45 views

How can a respiratory infection lead to a skin infection?

Example of a case: 5 children develop a bright red rash on the face and turns violet after a few days and then disappears. Then maculopapular rash appears on the trunk, buttocks and extremities. It ...
2
votes
0answers
40 views

How much does a human brain's metabolic rate vary? [duplicate]

Possible Duplicate: How does brain energy consumption depend on mental activity? Our brains consume about 20% of our energy when we're at rest. How variable is a human brain's energy ...
1
vote
1answer
60 views

Modeling intracellular interactions between sender and receiver bacteria

I am involved in a modelling task of a biological process described as follows: -- "Objective: to model behavior of a sender receiver type system The process goes as follows Pre-signal [PS] is in ...
1
vote
1answer
58 views

Gastro-intestinal physiology reference

I am a physicist but I have always wanted to understand how my digestion takes place in as much detail as possible. I have no idea about books or reference on the subject of Gastro-intestinal and ...
1
vote
1answer
95 views

What is the effect of Montelukast on the amount of IgE in blood?

I know that it decreases the amount of leucotrienes in blood. I saw a patient with high IgE altough under Montelukast medication. This suggests me that Montelukast does not affect the immunoglobulins, ...
1
vote
2answers
95 views

Effect on fitness of mutations

What is the distribution/probability density function (PDF) of impacts on fitness of new mutations? I very welcome any partial answer that does not give the whole PDF but just some information ...
1
vote
1answer
38 views

Dominance/recessivity of new mutations

What is the distribution/probability density function (PDF) of recessivity/dominance of new mutations? I very welcome any partial answer that does not give the whole PDF but just some information ...
1
vote
1answer
109 views

How to relate human metabolic model reactions and cancer drug targets / reactome items?

Trying to find a way to take a cancer drug (from CancerDR, for instance) and infer the metabolic reactions that are affected by it in the Human Metabolic Model. Essentially, I would like to know ...
1
vote
1answer
113 views

Carcinogens, how do they work?

The easiest carcinogenic thing for me to grasp is radiation, as it directly messes with DNA. Then it seems there are other compounds that simply mimic hormones, but these shouldn't necessarily cause ...
1
vote
0answers
122 views

On the definition of gDCW (gram dry cell weight)

I need some clarification on the concept of gram dry cell weight. The unit acronym gDCW stands for gram dry cell weight. My interpretation is that 1 gDCW is equivalent to 1 gram of dry cells, but I ...
1
vote
1answer
1k views

What would be the best design for spike-and-recovery and linearity-of-dilution validation experiments in one 96-well ELISA plate?

I have searched in the web for a detailed explanation of doing such validation experiment, but unfortunately couldn't find a satisfactory one. I came across the following sources: Thermo ...
1
vote
1answer
101 views

How might IVF (and related technologies) alter epigenetic marks?

I was reading up on KCNQ1, which encodes a voltage-gated potassium channel, and I discovered that it happens to be only maternally expressed. This is regulated by KCNQ1OT1, a non-coding RNA, which is ...
1
vote
2answers
425 views

By what mechanism does penicillin resistance usually develop in Streptococcus pneumoniae?

There are three mechanisms: prevention of the interaction between antibiotic and the target PBP; modification of the binding of the antibiotic to the PBP; hydrolysis of the antibiotic by a ...
0
votes
0answers
34 views

Few innervations to blood sugar regulation

Assume you have a case of young female where the intake of 75 grams of pure sugar leads to a rapid peak of blood glucose level (within seconds) plateau phase with very steady blood glucose level ...
0
votes
1answer
61 views

Parallel Autonomic regulation of Cough and Runny Nose

I describe here the serous inflammation of runny nose. Cough is mediated by Cough center. I think Runny nose is also controlled by the autonomic nervous system and probably by some reflex. Assume ...
0
votes
0answers
13 views

To decrease the amount of proteins in the lymphatic drainage for short term

I am looking for some mechanism which can decrease the amount of proteins in the lymphatic drainage only for short term. Assume there is no flow between capillaries and lymphatic system because the ...
0
votes
1answer
23 views

Which ionic channels of Pacemakers can work in very low frequencies in extrasystole?

At frequency 0-3 Hz. Like computer processors which can work at low frequencies and controlling under- and overvoltage. Normal most significant channels are Ca2+ and K+ that are changing. However, I ...
0
votes
0answers
25 views

Laser surgery to stop damaged Sinus node from beating

I am trying to find any publication about laser surgery to stop the damaged sinus node which cannot anymore beat. I could only find publications which modifies SA node function. I am not sure if it ...
0
votes
1answer
34 views

Manifestations of open foramen ovale in adults

I read that foramen ovale opens in 30% of adults. I do not know how much of these openings can then close again. Probably, none. It is not pathogenic if no symptoms. It allows blood to enter from ...
0
votes
8answers
596 views

How does the creative process of Biological Evolution work?

In order for nature to go from microbes to man, there needs to be new information. Where does this new information come from? It is understood that Evolution basically involves three elements. ...
0
votes
1answer
24 views

To understand clearly extraintestinal diseases

Extradistestinal disease seems to prefer to "bowel" diseases, I think this is about diseases outside gastrointestinal tract so stomach. Consider diseases ulcerative colitis and Crohn's disease ...
0
votes
5answers
283 views

Is evolution true as Darwin said? [closed]

I was telling the theory of evolution to my friends. But they asked me for the proof. They said, we are not seeing any such transition species at present. Neither we have such evidence for evolution. ...
23
votes
4answers
6k views

What does the human body use oxygen for besides the final electron acceptor in the electron transport chain?

My biology teachers never explained why animals need to breathe oxygen, just that we organisms die if we don't get oxygen for too long. Maybe one of them happened to mention that its used to make ATP. ...
22
votes
2answers
9k views

What causes fingerprints to form and why is the pattern formed unique?

I've found research that suggests that the reason we develop fingerprints is because they aid us with feeling surfaces (Scheibert, et al. 2008) and not to increase friction and help with the gripping ...
17
votes
2answers
324 views

How is menstruation not suicide in the wild?

Watch any wilderness special for more than a few minutes, and you'll notice a familiar pattern: when a predator catches the scent of blood on the wind, the hunt is on. Wounded animals make the best ...
17
votes
3answers
1k views

How long can I store extracted RNA?

If I extract RNA from a (leaf tissue) sample using a one-step phenol:chloroform extraction, how long can those samples be stored at -80°C? And how many times can I defrost and refreeze them before ...
17
votes
3answers
1k views

How does the immune system “learn” from a vaccine?

According to Wikipedia: A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one ...
14
votes
2answers
164 views

Relationship between our microbiome and personalized nutrition

Recently, it has been asked whether there are 'metabolic types' between humans that can benefit from a sort of personalized nutrition. One answer suggested that one discerning factor could be the ...
14
votes
3answers
3k views

What causes the development of antibiotic-resistant strains of bacteria?

I understand bacteria have become resistant to antibiotics due to selection pressures, but how do resistant bacteria process antibiotics when exposed to it, compared to non-resistant bacteria. Also, ...
13
votes
0answers
2k views

Why do we experience temperatures below 37 degrees Celsius as 'hot'? [duplicate]

We always prefer to be in 20-25° C, although our core temperature is about 37°? Why is our skin temperature lower than our core temperature?
13
votes
2answers
990 views

Is the EC50 of an activating protein for an enzyme a good indicator for the binding affinity Kd?

We work with a membrane protein system where measuring the affinity between the enzyme and the upstream activating protein has been difficult, and when measured in detergent solution, it is almost 100 ...
13
votes
1answer
3k views

How does a plant grow before photosynthesis is possible?

During photosynthesis, a plant translates CO2, water and light into O2. I assume the carbon C is further used for the growing process. I wonder how the plant grows before the time where photosynthesis ...
13
votes
2answers
4k views

How will rising carbon dioxide levels in the troposphere affect photosynthetic producers?

Much discussion has been had about the affects of climate change on plantlife, but how will rising carbon dioxide concentrations affect the photosynthetic process itself? Since CO₂ is a reagent in ...
12
votes
3answers
11k views

How many agarose gel bands are typical for circularised DNA

I am aware that circular DNA can be both relaxed and super coiled. However when running an agarose gel of the circular plasmid along with singly digested plasmid with BamHI and HindIII, I see 1 band ...
12
votes
3answers
936 views

How did the huge dinosaurs cope with gravity and loads on bones, etc.?

It's very costly to be a huge animal. Your mass grows in cube when you scale up, but you still only have two/four legs to support the same weight. This increases the pressure that your body needs to ...
12
votes
2answers
397 views

Are there any plants that fix their own nitrogen?

I know that most nitrogen is fixed through industrial processes and bacterial symbiotic relationships. However, are there any plants that can fix their own atmospheric nitrogen?
12
votes
1answer
217 views

Abiogenesis: Beyond the research journals as a lead in to discussions on evolution

I just came across this abstract: Aminoacyl-tRNA synthetases (aaRSs) are responsible for creating the pool of correctly charged aminoacyl-tRNAs that are necessary for the translation of genetic ...
11
votes
3answers
134 views

Do humans perceive temperature or heat-flux? (or both?)

The general understanding is that when I touch an object, I perceive its (relative) temperature. A metal object at room temperature, however, will often feel cool to the touch. This leads me to ...
11
votes
1answer
817 views

Is there an evolutionary advantage to crying when sad?

It seems as though the act of crying when sad does nothing to relieve that sadness. Is there an advantage to crying from an evolutionary perspective, or is it the end result of a different process? ...
11
votes
4answers
1k views

Has there ever been an attempt to create nutritionally tailored food for adult human consumption?

For all domestic animals, and for all animals kept in laboratory, complete and precise composition of perfect food is figured out (cat food, dog food, cattle, rats, laboratory monkeys and apes) -- ...

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