4
votes
1answer
286 views

What phenotypes can arise from gender-related aneuploidy?

Humans normally have 46 chromosomes (two copies - one from each parent - of each of the 24 chromosomes: [1:22] + [XX or XY]). Aneuploidy is an abnormal number of chromosomes - Down's syndromes is an ...
4
votes
1answer
94 views

In a vertebrate chimera, are particular organs homogenous genetically?

I have read that a chimera is an organism with two or more sets of DNA, with every cell having one of the sets. Is it possible and common for the two or more sets to be present in the cells of a ...
11
votes
1answer
236 views

Evolution of long necks in giraffes

In this question, the OP uses giraffe necks as a supportive example of evolution. Is the mechanism described in this post accurate? At some point, I thought I remember hearing that giraffes did not ...
8
votes
2answers
279 views

Do antibiotics attenuate immune response on subsequent exposure to same bacteria?

A healthy immune response to a bacterial infection includes "memory" to permit the body to thwart subsequent exposure to same bacteria. What are the dynamics of using antibiotics on initial exposure ...
4
votes
1answer
144 views

Vigorous shaking for HFR interrupted mating

I am trying to reproduce E. coli interrupted mating using an HFR strain, and I read that the cultures should be vigorously shaken at times to interrupt the DNA transfer from the F+(HFR) donors to the ...
13
votes
2answers
761 views

Impact of Alan Turing's approach to morphogenesis

Shortly before his untimely passing, the computing pioneer Alan Turing published his most cited paper The Chemical Basis of Morphogenesis (1952). The central question for Turing was: how does a ...
3
votes
3answers
155 views

What Defines a Food as Edible?

With many foods today containing chemicals, agents and preservatives etc... What biological criteria must a new food and its constituent components satisfy biologically, to be defined as edible? ...
4
votes
1answer
482 views

Are there any effects of elevated Cysteine levels on cognitive function?

I'm looking at this diagram of homocysteine metabolism and see two distinct pathways that the amino acid may get metabolized to: with vitamin B12 it gets converted back into methionine, while with B6 ...
7
votes
2answers
146 views

How was the guided daily amount (GDA) calculated?

We are constantly shown nutritional information on food packaging stating this food contains "x" amount of your guided daily amount. A linked to the values is here. How were these values calculated? ...
11
votes
3answers
1k views

What happens to dextrorotatory amino acids in humans?

As indicated by this question, most of the amino acids in the human body have the L-chirality. As enzymes also have handedness, what happens to the D-amino acids that end up within the human body? Are ...
9
votes
2answers
246 views

Do twins “run in the family”?

My wife and I recently found out that we are going to have twins and so nearly everyone asks if we have a family history of twins. Now I know that the answer for me is that it doesn't matter—as ...
4
votes
1answer
1k views

What does vitamin B6 and B12 absorption depend upon?

I'm looking at my question about homocysteine metabolism and am doing a followup inquiry into vitamins B6(Pyroxidine) and B12(Cyanocobalamin). I've found this interesting bit about vitamin B12 and am ...
3
votes
1answer
581 views

How long can a unicellular organism live without nutrition? What happens after that? Does it depend on the domain?

Say I have three unicellular organisms: a eukariote, a bacterium and an archaeon. If I cut off nutrition from them at the same time, how long will it take for them to die? What will their death look ...
5
votes
3answers
1k views

How did butterflies evolve to have eyes on their wings?

Some butterflies, such as the UK native Peacock butterfly (Google Image Search) have markings on their wings that look just like eyes, complete with a white fleck to imitate a convex, transparency ...
1
vote
1answer
57 views

What is the role of Homocysteine in cognitive function?

I'm looking at this link : Homocysteine and cognitive impairments and am looking for more information on specific cognitive impairments associated with elevated levels Homocysteine. That article is ...
1
vote
2answers
492 views

What is the most complex plant form?

At school we were told on scale of 0 through 1000 the animal kingdom ranges from amoeba the simplest/primitive being at 0, and Humans the most complex animals at 1000; what are the equivalent ...
7
votes
3answers
226 views

What alternatives are there to the amyloid hypothesis?

Given the recent failure of the Bapi clinical trial, there is a lot of questions that have arised from he amyloid hypothesis. However, I can't really think of many other mechanisms that don't involved ...
4
votes
1answer
153 views

Is there a way for a 19th century scientist to prove that the octopus doesn't revive?

Say a sophiscated scientist in the 19th century noted that applying soy sauce on a dead octopus leads to movement of the legs, as a result of the voltage differences resulting from the salt in the soy ...
13
votes
2answers
776 views

Is the EC50 of an activating protein for an enzyme a good indicator for the binding affinity Kd?

We work with a membrane protein system where measuring the affinity between the enzyme and the upstream activating protein has been difficult, and when measured in detergent solution, it is almost 100 ...
3
votes
0answers
99 views

RMSD during conformational transition in proteins

When I was investigating the differences between protein structures obtained by X-ray crystallography and NMR spectroscopy, I found the paper [1] compairing structures of several proteins resolved ...
2
votes
2answers
725 views

What are the most important differences between HSP70 and HSP90?

Question originally asked on Quora. These proteins have many functional similarities, so why do cells need both to handle unfolded proteins?
1
vote
0answers
66 views

When should endocytosis inhibitors be used in cell binding assays?

I'm beginning to do some cell-binding assays and I would like for my proteins to not be endocytosed by my mammalian cells. Typical suggestions are for the cells to be kept on ice and that the binding ...
2
votes
3answers
244 views

Where can I find a list of diseases and their incidence?

Say I am studying a particular disease and I know that its incidence is 0.8 per 100000 children below the age of 18, how would I find the incidence of a whole bunch of other pediatric diseases (or ...
8
votes
3answers
199 views

What would need to be discovered to prove there is extraterrestrial life?

Curiosity is on the Martian surface and is equipped with a slew of laboratory equipment. What would Curiosity need to discover to prove there is or has been life on Mars? Would it have to find DNA (or ...
5
votes
3answers
133 views

Do dogs have something different about their physiology that allows them to pant without hyperventilating?

I was wondering this as I considered how effective panting would be for humans as a means of cooling.
5
votes
1answer
123 views

Does every gland type have stem cells for regeneration?

Is there any gland in which there are no stem cells? I know that: sebaceous gland is maintained by unipotent stem cells thyroid gland - some stem cells, apparently unipotent Glands about which ...
4
votes
1answer
88 views

Determining if a Protein Model Contains a Backbone Clash

I have an ensemble of homology models of a protein, and I now wish to remove those models which have backbone clashes. I could obviously check by eye but this is subjective and probably will not be ...
6
votes
1answer
120 views

Ideal low-protein binding membranes

I'm looking through the literature on the topic. It seems like hydrophilic PVDF membranes are ideal for low-protein binding but it also sounds like Regenerated Cellulose is an appropriate ...
4
votes
1answer
51 views

How to find ion/water channel related genes

We now have a collection of transcripts at hand. We would like to investigate some particular ones, which are ion/water channel related. How to perform this? Could anybody point out how to find the ...
1
vote
1answer
33 views

Could silicon oil block Na+ ion channels in the membrane of an axon and prevent Na+ influx?

Could silicon oil block Na+ ion channels in the membrane of an axon and prevent Na+ influx? I have been wondering if Na+ influx could have been a diluting factor in anterograde fills. If so, could ...
4
votes
1answer
89 views

Why isn't there any repulsive force between Na+ and K+ disrupting thier roles in transmembrane voltage/ action potentials

Pretty self explanatory question. I have a basic grasp on the "How" and "Why" of Reversal/Action Potential in and between neurons, but this question lingers.
5
votes
1answer
303 views

What are the units of enzyme activity?

I was looking at this graph of turnip peroxidase activity and I saw that they use units of 1/sec for enzyme activity. What does this unit intuitively represent and how is it calculated?
9
votes
1answer
2k views

Why is GTP gamma S non hydrolyzable?

GTP gamma S is routinely used in studies of G proteins to stably activate the G protein. Comparing the structures of GTP gamma S and GTP, the Sulphur atom replaces the Oxygen attached to the leaving ...
5
votes
3answers
186 views

Why don't flies avoid the motorway?

Flies have a short lifespan, therefore evolution should technically happen over a shorter period of time (years). Flies die all the time from getting hit by cars on the motorway. Those flies that ...
4
votes
1answer
80 views

Is there an advantage to having cellulite

There are many ads nowadays advertising cellulite removal, and it causes me to wonder if there is an advantage to having cellulite or if it is just a result of too much fat unevenly spread? Is it ...
19
votes
2answers
544 views

Why is rabies incurable?

I'm still not sure about the mechanics that lead to rabies being incurable. I know that it can be treated before any symptoms show up, but why is it that once symptoms show the person is a dead man ...
8
votes
1answer
614 views

Does every mitochondrion in a cell contain the same DNA?

I know that mitochondria of eukaryotes have their own DNA, more similar to that of bacteria than to the rest of the cell's DNA. I also know that a cell can have plenty of mitochondria, and I ...
9
votes
2answers
24k views

What is a coupled reaction and why do cells couple reactions?

I was wondering what exactly a coupled reaction is and why cells couple them. I read the wikipedia article as well as several others, such as life.illinois.edu but I still don't get it. Could ...
11
votes
2answers
452 views

When did vision evolve for the first time?

Today I wondered what the first organism to evolve vision would have been. I assume that it would have been kind of primitive and basic, but of course extremely innovative and eventually useful to a ...
6
votes
1answer
61 views

Can an organism obtaining a part of its genome via horizontal gene transfer be called a “hybrid”?

Wikipedia definition of "hybrid" offers many competing definitions. But most seem to be centered on sexual-reproduction gene transfer. Is there an official (in a textbook or widely accepted peer ...
6
votes
1answer
130 views

Why are pilots under the illusion of gaining altitude without doing so?

We had a lecture about the balancing systems of the body (mainly the otolith organ / semilunar canals) in which a case was described where a pilot crashed into a ship. He was supposed to keep his ...
8
votes
1answer
329 views

Why aren't mitochondria and plastids considered symbiotes of eukaryotic cells?

Mitochondria and plastids have their own DNA, their own membranes, and their reproduction is not tied to the reproductive cycle of the host cell. However, they are considered to be organelles rather ...
2
votes
1answer
110 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
3
votes
0answers
51 views

Physiological or molecular difference before and after sleep?

I know that the details of the process of sleep aren't entirely known, but have always wondered why I feel rested after sleep. Biologically, what differences can be directly observed in the human ...
11
votes
1answer
798 views

How does evolution produce complex organs

I've been wondering lately how evolution manages to produce complex organs. It is pretty obvious to me how evolution would select some minor traits like size, resistnce to illness or climate. There is ...
4
votes
1answer
159 views

Why would deers keep crossing a river full of crocodiles while some of them have been killed?

I recently watched a clip on Discovery Channel, where I saw deers crossing a river full of crocodiles, ignoring the fact that some of them would have been killed doing so. What could be an ...
6
votes
1answer
68 views

(Rough) Model for DNA evolution in E. coli genes

I need a model of in-gene DNA drift. I'm not interested in bacterial phylogenies alone. Here is what I understand: Sequences corresponding to genes have both exons and introns, but in bacteria the ...
13
votes
3answers
2k views

When has an organism evolved enough to be called a new species?

Imagine that we take a population of horses, split them in half and place them in completely different environments. The two species will evolve separate from each other and because the environment is ...
3
votes
7answers
385 views

Introductory books about evolution

This days I read some debates on evolution. That made me more interested to read something reliable on topic - I mean books. I'm christian - although I think it doesn't matter on that topic - and I ...
-2
votes
1answer
77 views

What causes mutations in regulatory genes? [closed]

In detail, what causes mutations in regulatory genes?

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