8
votes
2answers
239 views

If Tumors have lots of mutations in them how is it the immune system can't detect them?

If a cancerous tumor has a lot of mutations in them why can't the immune system detect them? If a person has cancer could this somehow alter the person's immune system so it doesn't function ...
1
vote
1answer
230 views

Drinking soda triggers tingling on a tiny spot on my upper back… but how? [closed]

The title pretty much says it all. Yes, I know it doesn't make sense. That's why I'm baffled. For the past week or two, I've noticed that drinking soda seems to cause a tingling/stinging sensation ...
8
votes
1answer
274 views

How do plants benefit from their seeds being buried?

Common planting advice, when starting many plants from seed, is to bury the seed some small distance under the soil. It seems like most plants (at least members of class Dicotyledonae) will grow a ...
2
votes
1answer
30 views

Testing CO₂ for cell culture

I'm am refurbishing some old CO2 incubators. I would like to test the precision of the CO2 sensor. There is a sample port on this incubator. What sorts of methods are commonly used to measure CO2 in ...
6
votes
1answer
7k views

Is consuming proteins different vs. consuming amino-acids and how?

Yesterday I had a discussion with a friend. He said that consuming proteins and amino-acids is different. He said that those who grow muscles would agree on that. I wanted to argue against that ...
2
votes
1answer
54 views

Can stress-induced cortisol reduce diabetes type I?

Let us consider a patient with type 1 diabetes. I think it would be safe to say that diabetes is an autoimmune disease. Now let us suppose this patient comes under stress. As far as I know, cortisol ...
1
vote
2answers
38 views

Is it possible to merge the genomes of photosynthesizing and electron-transporting bacteria to make an electric cell?

I had an idea of making electric current from bacteria. There are some bacteria that can photosynthesize, and some others are capable of transmitting electrons through each other. Is it possible that ...
2
votes
1answer
85 views

How long does it take unused antibodies to clear the system?

Say you have the flu and a normal immune system. Now you're all better but your antibody level is still elevated. How long does it take for those antibody levels to go back to a base value?
3
votes
1answer
577 views

What is this black insect (wasp-like?) South America?

I live in the Pacific coast of South America. Seems to have two wings, like a wasp's. The "tail" is a bit bulky but is only connected to the rest of the body by a thin part. It's black overall. The ...
5
votes
1answer
379 views

Mouse Colony Software

I am looking for a good mouse colony census program that tracks the mice we have in the lab, breeding success of breeders, lineages, multiple user access, etc. Jackson labs has a program that does ...
23
votes
3answers
3k views

Which organism has the smallest genome length?

Which animal/plant/anything has smallest length genome?
3
votes
0answers
100 views

L-tryptophan in mammalian cell culture

Why must the concentration of L-tryptophan be kept to a relatively low level when culturing mammalian cells? It's an essential amino acid, so I cannot fathom why low concentrations as opposed to ...
4
votes
2answers
546 views

How many copies of a gene?

I am studying mathematical models of transcription and translation and I am wondering: In a particular genome, how many copies of a gene coding for one particular protein should one expect? Are they ...
1
vote
2answers
22 views

What are blood group determinants? [closed]

I am trying to understand if they are the same as the blood antigens. The books I have tried to read say something about them being the antigens on the surface of the red blood cell.
0
votes
2answers
75 views

Molecular graphics

anybody know of some great free molecular graphics systems that can allow for PDB code input? I prefer that it doesn't use Java. I also prefer that it is online, although if there is a great system ...
3
votes
1answer
90 views

Is sequencing error a function of the nucleotide being read?

Checking out on Google Scholar, I can see that for Illumina (just to consider one example) the sequencing error rate is of the order of 0.001-0.01 per nucleotide. Talking about sequencing error, let'...
25
votes
1answer
10k views

What do you see when your eyes are closed?

If you are in pitch black and you close your eyes, you sometimes can see strange shapes of various colors. A lot of the time these shapes and colors change as you observe them. This phenomenon still ...
2
votes
1answer
46 views

How do catenanes form when DNA replicates?

So I am taking a course in DNA replication and repair. And we are talking about catenanes forming when DNA replicates (two circles of dsDNA interlinked) How is this possible?
0
votes
2answers
248 views

Binding of Multivalent Antibody to mutiple epitopes?

A multivalent antibody molecule such as Immunoglobulin M Immunoglobulin A etc bind to more than one antigens or epitopes but I am confused about that wheather these multivalent antibodies bind to ...
4
votes
1answer
204 views

Fruit-bearing tree identification

Just moved into a new house in Puerto Rico and I found this tree in the back garden. Can anyone tell me what tree this is, and whether its fruit is edible?
3
votes
2answers
80 views

Why are our bodies created to itch when histamine is released by our immune systems?

Why do bug bites and cuts itch when scratching them clearly doesn't help us survive? Did our early ancestors need to rely on this itching sensation, or is it just that the receptors for itches just ...
1
vote
1answer
46 views

Is there a good site or software to see if a primer pair spans an exon junction?

I am going to perform some RT-qPCR tests to validate an experiment.  I'm currently in the process of ordering primers, and I would like to get them from the Harvard Primer Bank since these have been ...
1
vote
0answers
16 views

How are split inteins joined?

Do they form a peptide bond? Or is it just some affinity/van der Waals interaction? Is the mechanism enzyme catalized? Are the residues/moieties at the join site known? Could they be introduced to ...
0
votes
1answer
131 views

How much penicillinase is needed to deactivate 125mg of amoxicillin?

How much penicillinase is needed to deactivate 125mg of amoxicillin? Penicillinase in penase concentrate from CPC. 20,000 Levy Units/ml/min I need IU of 125 mg of amoxicillin. Please note that the ...
4
votes
1answer
70 views

How many traits can a multivariate breeders equation handle?

The multivariate breeders equation (MBE) by Lande predicts the change in a trait $\Delta \bar z$ (response) as $\Delta \bar z = G \beta$ where $G$ is a genetic variance-covariance matrix and $\beta$...
1
vote
1answer
50 views

How does the MET gene work and what happens when the promoter region gets mutated?

I am doing research on inherited risk of Autism Spectrum Disorders(ASD) due to common Copy Number Variants(CNVs) One of the mutations is the 'CC' variant of Rs1858830 in the promoter region of the MET ...
4
votes
3answers
200 views

Phospholipid Bilayer structural reversal

What would happen if the phospholipids in the phospholipid bi-layer were reversed, the fatty acid tails now facing outwards and the phosphate heads facing inwards? I'm assuming this will not affect ...
1
vote
0answers
28 views

Is a Ribonuclease Inhibitor protein the only mechanism employed by the human cell to protect cellular RNA from degradation by endoribonuclease?

Are there any other methods of protection for cellular RNA from degradation by endonuclease (specifically the Pancreatic Ribonuclease RNase II (Eosinophil-derived neurotoxin) and RNase III (Eosinophil ...
0
votes
1answer
85 views

Extinction of species with extant descendants

From what I've seen, species such as Homo heidelbergensis which have extant descendants are classified as extinct, which makes sense as far as it goes. However, given that species exhibit a continuum ...
2
votes
2answers
65 views

Database of medically validated SNPs

I'm looking for all possible sources of clinically tested human SNPs. There is a handful of databases that store SNPs (like dbSNP), but I only need those that have validated presence/absence of ...
12
votes
2answers
367 views

If all B cells are present at birth, why should the primary response to an infection take longer than the secondary response?

When learning about the immune response, my teacher mentioned that all the bodies B cells are present at birth, and there is one to counter every disease. But if this is the case, why should the ...
2
votes
2answers
71 views

Career progression through biosafety levels?

Does a career in infectious disease typically progress through biosafety levels, or do people select one and specialize their training in procedures specific to those hazards? That is, say Dr. ...
1
vote
0answers
27 views

Do bacteria develop a resistance to antimicrobial peptides at the same rate as against “regular” antibiotics?

From what I understand, antimicrobial peptides are roughly grouped into three structural sets, with large variations present between different groups as well as within the groups. Their anti-microbial ...
3
votes
0answers
116 views

What is this ground dwelling, funnel web spider in Montana?

I've killed dozens of what appears to be the same type of spider. I've included pictures of 2 individuals. I've seen them in all sizes from 1-4". I'm in Missoula Montana. They're aggressive, they ...
10
votes
1answer
775 views

Did not understand a small excerpt from a research paper

Was going through this paper, among multiple things that i did not understand, I came across this part: Each amino acid residue of a single window was encoded into a unitary bit string of length ...
1
vote
0answers
23 views

GO term for orthologous gene IDs

I have a list of orthologous gene IDs from the first supplementary file in here. The gene IDs are of the following type: ...
2
votes
0answers
40 views

Thinking quickly causes elevated mood

I read this article: http://www.sciencedaily.com/releases/2006/09/060926171045.htm It says, "When people are made to think quickly, they report feeling happier as a result. They also say they are ...
3
votes
0answers
23 views

How is atrophied muscle different than normal muscle in a chemical or biological way?

I am a writer with a question for a story I'm working on. In it, the character suffers from muscle atrophy due to spinal damage. So that I can portray this accurately, what would cause this type of ...
1
vote
1answer
14 views

What was the first gene(s) found to code for ncRNA

I could not find a source that states what the first gene found to code for ncRNA was. Someone told me, however, it was a gene that coded for either rRNA or tRNA. To this point in time I have had no ...
0
votes
1answer
25 views

What motivates birds to make birdsong?

I was pondering the question "Why do humans make music?" and on an intuitive level, my answer was "because of the feelings it evokes of course!" But I then wondered, what about songbirds? Does a ...
12
votes
1answer
397 views

Can anyone identify this bird?

Can anyone identify this bird: it looks like a zebra finch but they are not native to UK are they? Photo taken from my garden in Shoreham, West Sussex on 16/8/2014.
0
votes
0answers
16 views

What is the best aCGH normalization procedure for hyper-ploid tumor samples?

I'm currently working on aCGH data of Triple Negative Breast Cancer patients xenografts and primary tumor samples. A substantial amount of my samples is highly aberrated which leads to offsets of the ...
10
votes
3answers
7k views

Why is the number of PCR cycles limited?

I've been told that the maximum number of cycles in PCR is between 20 and 30. Is this true, and what are the reasons for this limitation?
2
votes
1answer
195 views

Will salting the ground kill insects and spiders?

I want to kill the insects and spiders living in my egress using something non-toxic to humans, dogs. I was thinking copious amounts of salt would kill earth dwelling bugs and what appears to be ...
1
vote
0answers
212 views

What are the exact differences between stereocilia and microvilli?

This is a question in an old exam of Histology. I tried to answer the question, and I've made many searching attempts, but without resulting in any fixed/exact information. In some articles on the web,...
3
votes
1answer
204 views

What is a functional screen?

I was going through this paper, but did not understand a term. What is the meaning of functional screen? (I am not a biology student, I don't understand much, and a small simple explanation would ...
2
votes
0answers
127 views

Is dysharmonia an actual disease or something only Oliver Sacks believes in?

In his book Musicophilia, Oliver Sacks discusses a case involving a woman named Rachel Y. who lost the ability to process harmony in a car accident. He then explains how this lead to simultanagnosia. ...
1
vote
1answer
16 views

Are Protocadherin Gamma Cluster transcripts considered separate genes?

The PDCH@ cluster of genes share exons and are therefore isoforms of each other. However, they are considered separate genes, by both HUGO and Ensembl. A "gene" is defined as "a locus of co-...
2
votes
1answer
76 views

Through which mechanisms did the Drosophila Histone Cluster evolve?

The Drosophila Histone Cluster is a gene cluster that contains more than a hundred copies of a sequence that encodes several histone proteins. These copies are very similar. My question is what ...
1
vote
0answers
26 views

Are there any auto-immune diseases caused by T cells not detaching from antigen presenting cells (APCs)?

By not detaching I'm referring to after they have formed an immunological synapse, if they don't ever detach.

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