4
votes
1answer
207 views

Plasma cells and memory cells

What decides whether an activated B cell will get converted to plasma cell or memory B cell? Is it necessary that out of a mitotic division one will convert to memory B cell and the other to plasma ...
5
votes
2answers
279 views

Do we have enough diversity of antibodies to overcome almost any antigen?

I always wonder about the capability of diversity of our antibodies. Do we have enough antibodies to fit to every kind of molecule? Wont't it be easier if our antibodies are like clay and can be ...
2
votes
1answer
672 views

Why do humans bury their dead?

As far as we know Ape Men or the Neanderthal Man was the first to bury its dead. My question is why. I don't think they practiced religion or believed in spirits or faith or stuff like that. ...
5
votes
1answer
58 views

What regulates these two methods of splicing?

Alternative splicing can shuffle the exon order and select from the exon sequence of a single gene site to provide a combinatorial selection of possible transcription products from the one gene. Can ...
2
votes
1answer
456 views

Comparing BLAST and the Smith-Waterman algorithm

I've been asked: how does BLAST improve dynamic programming accuracy? I do know that BLAST is based on heuristic approach that approximates the Smith-Waterman algorithm and that the Smith-Waterman is ...
7
votes
1answer
59 views

Intracellular lipid transport

I know that lipids are carried around the body in the blood either as micelles or by lipid-binding proteins which allow them to be solved. Lipids can't always be integrated in a membrane though, the ...
2
votes
2answers
123 views

Prenatal Marketing

This is for a short story idea. Is it possible to modify the DNA of a child to make their metabolism more susceptible (physical response, addiction, etc) to a certain type of chemical i.e. a chemical ...
2
votes
0answers
60 views

Movement of stem cells from mother to fetus

Recent results from J Lee Nelson and colleagues (Sci Am. 2008 Feb;298(2):64-71; available as full text through Google) show that cells from the mother were found in a person aged 46. Logically, these ...
2
votes
1answer
75 views

How to bind antibodies to study their properties?

I want to experimentally look at the behavior of antibodies. To do so, I need to be able to bind these antibodies to a substrate. Does anybody know of a good substrate to use that antibodies bind to? ...
3
votes
2answers
713 views

Just how light-sensitive is ethidium bromide?

One lab I was in was paranoid about keeping it in a foil-wrapped conical tube; my current lab leaves it out on the bench (and it works fine for staining gels). It's the same company/concentration in ...
3
votes
1answer
130 views

How do different tissue culture matrices affect background in fluorescent microscopy?

In response to my previous question, I've been reading up a little bit on poly-D-lysine, Collagen I, Collagen IV, laminin, and other tissue culture coatings that promote cell adhesion. I've always ...
1
vote
0answers
44 views

What parts of the brain are involved in regulating blood pressure in mammals?

I'm reading this Wikipedia article on blood pressure and its regulation, and it mentions that medulla is involved. however, I vaguely remember reading another article on Wikipedia and it mentioned ...
4
votes
1answer
84 views

Measuring sugar content of a tree

I would like to grow mushrooms on oak trees I can harvest from my property. I've read that the best results will be when the sap is rising but the tree hasn't budded yet. The mycelium feeds on the ...
4
votes
2answers
816 views

How to convince suspension cells to adhere more tightly?

I'm developing a cell-based assay in 96-well plates that requires adherent cells, as they need to be washed at least twice during the protocol. I'm using in-house strains of HT1080 cells (some ...
7
votes
1answer
72 views

Excretion of monovalent and divalent ions in sharks

I have heard that sharks excrete $\ce{Na+}$ and $\ce{Cl-}$ by their gill surfaces but divalent ions like magnesium are excreted through feces. What could be the reason behind this?
1
vote
1answer
323 views

How do changes in temperature affect body weight in humans?

What would be effect on weight of individuals if we bring a fully adapted (to cold climate ) human individual and a fully adapted to very hot climate individual to a moderate climate region?
0
votes
1answer
64 views

Why is epinephrine not part of the somatic nervous system?

I learned that the adrenal medulla releases epinephrine, which is a vasodilator of the vessels that lead to the skeletal muscle. I also learned that somatic nervous system only uses Achetycholine as ...
2
votes
2answers
92 views

Evolution after the development of sexual reproduction

My understanding of evolution is that genetic mutation occurs in individual members of a species, and they become a new species. Isn't a definition of species a group of genetically similar organisms ...
3
votes
1answer
104 views

Superposing DNA

I have a series of protein models with DNA docked. I now want to superpose the DNA on a reference DNA molecule and extract the translational distance applied and the rotation angle used. I can ...
2
votes
1answer
127 views

Does precipitation influence the UV spec reading?

I have been checking my sample for Hydroxyl radical scavenging activity. I have dissolved Hydrogen peroxide in Phosphate buffer. My sample is clear and reagent is also clear but when I have mixed my ...
6
votes
2answers
149 views

Can any species be bred selectively/engineered to become as diverse looking as dogs?

I've done some research and it appears that dogs are the most diverse looking single species of mammals. The questions that interest me is - are dogs special in respect to genes/gene activation ...
4
votes
1answer
86 views

What determined the evolution of different faces in humans?

The most distinctive characteristic of a human is it's face - it is unique among each individual (with the exception of identical twins). It is uncertain to me if whether we best identify other humans ...
3
votes
0answers
75 views

Food Intake versus ability to flee among birds, particularly the hummingbird?

Logically speaking, if a hummingbird drinks too much nectar, it will be temporarily overweight and less able or unable to fly to escape danger. However if the same hummingbird doesn't drink enough ...
2
votes
1answer
271 views

What is this insect?

These photographs were taken today in Marseille, in the Mediterranean coast of France. My French friends inform me that these beasties are called cousins because they are "cousins" of mosquitoes ...
7
votes
1answer
100 views

How do animals perform detailed active camouflage?

We often see videos of octopuses and chameleons changing their color to suit their surroundings. If it was a simple color change from white to red, it'd be understandable, but some of these animals ...
3
votes
1answer
110 views

Can you cure allergies?

A common solution is allergy shots, which helps you adapt to the allergy. But are there ways to tell the body that this allergy is safe and there is no need to amount a response to it? So that there ...
-2
votes
1answer
456 views

Are we evolving to age slower, or to live longer aging at the same rate?

I wonder why most of us find senior people lovely and charming. Is it because to love grandpa and granny is vital to our survival as a species, in the same way as we love babies? If so, it would mean ...
3
votes
1answer
104 views

Would non-human carnivores be able to survive on farmed foods?

Certain creatures that are considered carnivores are non-obligate carnivores and are technically omnivores (such as wolves/dogs). How different is the potential digestive ability of these species ...
2
votes
1answer
613 views

Optogenetics - How do microbial opsins work?

I'm just introduced to the optogenetics method and am having some trouble grasping the genetics (of the optogenteics) part of things. So we have Retinal and Opsin that form Rhodopsin molecule that ...
11
votes
1answer
2k views

Why does oxygen bind to hemoglobin in an specific angle?

There is an specific angle of the bond between oxygen and hemoglobin in lungs, which I don't know, but what interests me more is the question, why is it specific?
1
vote
0answers
59 views

Removing bacterial contaminants from resin

We have a few Strep-tactin columns that had some growth in them and we would like to regenerate the columns back since the resin is quite expensive. Basic goal: remove the brown stuff. So far, I've ...
0
votes
1answer
61 views

What is a good review article source for Physiology?

I am looking review articles for Physiology. For instance, Physiological explanation of steps of measurement of the metabolism by Douglas-Haldane. There is no section for Physiology or metabolism in ...
2
votes
1answer
269 views

How do fully dioecious plants determine sex?

I know that a minority of plants are fully dioecious, with adult plants producing either only male or only female flowers. When is this sexual differentiation determined? Is the seed of such a plant ...
2
votes
1answer
81 views

Identify this waterfowl species?

I've been unable to find anything on the Google resembling this bird. I took the photo in Virginia Beach, VA around 2010, October, I think... It appears to be between winter and summer plumage but I'm ...
5
votes
1answer
243 views

Is there a practical upper limit to amount of nucleotides or genes in a transformed plasmid?

I'm currently working on a synthetic biology project which involves working with lots of different parts. I would ultimately like to integrate these genes by transforming a single plasmid. I've heard ...
7
votes
1answer
270 views

Do non-human animals suffer from insomnia?

And how do we know whether they do or not? § If sleep is a physiological need, it seems weird that we become unable to fulfill on demand even in the absence of any obvious physical issues. We would ...
2
votes
1answer
163 views

Can antibodies be formed against white blood cells after blood transfusion?

If antibodies are produced against other blood groups' red blood cells, why can't antibodies form against white blood cells, of any blood group? (even the same one, as MHC will be different in almost ...
4
votes
3answers
154 views

What is the difference between different brain regions

The brain is separated into different regions, and different regions perform different tasks. Well, what are the differences between these regions on the cellular/systemic level. The brain is made up ...
5
votes
3answers
266 views

Can extinct animals be cloned?

Scientists have found mammoth blood, and are planning to clone a mammoth. How does one go from having its blood to a full blown living mammoth? Is it possible? Why does it matter if the blood is ...
5
votes
1answer
140 views

Would my hands sweat this much if I wasn't wearing gloves?

I've wondered about this for a long time, and hopefully someone here has a reasonable answer. I'm a cell and molecular biologist, and much of my time at the bench is spent wearing (usually nitrile) ...
2
votes
1answer
582 views

Ammonia smell after physical exercise? What is the explanation? [duplicate]

After exercising vigorously one can sometimes smell ammonia and it feels like it's coming from within the nose actually. There is no indication that others can smell it when I do (i.e. seems to be ...
3
votes
1answer
179 views

What is the best way to clean plastic flasks that have been used for cell cultures - is virkon a good idea?

When you use cultures e.g. insect cells, which are infected with virus one way to clean the (plastics) shake flasks is with virkon. Which is the most effective way to clean your flasks in order to ...
1
vote
0answers
164 views

Ligase Chain Reaction: Determining the annealing temperature for gene synthesis

Using the tool Gene2Oligo I have a set of DNA oligonucleotides to synthesize a gene using ligase chain reaction (LCR). The average melting temperature is 72 degrees Celsius. I am going to use a the ...
4
votes
1answer
443 views

Meat and mushroom allergies, why are they so rare?

There are a lot of food allergies, but for some reason not to meat (mammalian meat or poultry) or mushrooms. I've googled a bit, and now I know that one can actually have a meat or mushroom allergy, ...
1
vote
2answers
107 views

Inverse of dopamine reuptake inhibitor?

The wikipedia article on the dopamine transporter gives examples of some drugs whose effects are mediated by the inhibition of the dopamine transporter, such as cocaine and amphetamines. Are there ...
3
votes
3answers
469 views

What kind of tree could this be?

This may be a strange question, but does anyone know what kind of tree this could be? I know, it's just a comic, but these trees, at “walking distance” within that comic are easily identifiable as ...
3
votes
3answers
164 views

Blood pressure during exercise

What happens to blood pressure when we exercise? Does it increase, decrease, or remain the same? If it does increase, why are patients with high blood pressure recommended to exercise?
5
votes
1answer
291 views

Skeletal muscles in clam

Although skeletal muscle fatigues fairly rapidly, clams have a protein called paramyosin that allows them to sustain contractions for up to a month. What might be the role of paramyosin at the ...
2
votes
1answer
117 views

What kind of mushroom(?) is this?

I found groups of these growing in the Lassen National Forest (Susanville, CA, USA). It looks like some sort of mushroom. I have Googled extensively, but can't seem to find a match.
2
votes
0answers
58 views

Why do conker flowers grow upwards?

Most trees I know that have their flowers in groups hang these groups down. I noticed, however, that conker flowers grow upwards! I guess that growing against gravity requires special effort, so ...

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