8
votes
1answer
118 views

How to validate the regulatory interactions inferred from gene expression data?

My algorithm learns regulatory interaction between genes using Bayesian Network approach from gene expression data. After the algorithm has converged to a network of interacting genes, how to validate ...
2
votes
1answer
54 views

Can plants directly use sulfuric acid?

In the explanation of the sulfur cycle, it is often said that sulfur moves from the atmosphere to the ground by acid rain in the form of sulfuric acid. Can plants directly use sulfuric acid to ...
7
votes
1answer
196 views

Why do we still have genetic disorders that show anticipation?

Anticipation whereby symptoms of genetic disorders occur earlier and with more severity as it is passed from one generation to the next. So wouldn't these inherited diseases over a few hundred ...
3
votes
1answer
144 views

Why does weight loss lower blood pressure?

I have read that weight loss is an effective lifestyle modification for people with hypertension, and systolic pressure may be reduced by up to 1-2 mmHg for every 1kg of weight lost. What is the ...
6
votes
2answers
477 views

Skin porosity in glans penis when erect

(Apologies if this is a too weird/inappropriate question in this forum. I only thought that I ask it since it happens to be part of human life.) The skin on a human typically blocks many substances ...
4
votes
1answer
124 views

Does DNA analysis allow determining amount of chromosomes?

Nowadays it is possible to sequence the DNA of extinct species, such as the Neanderthals, the Denisovans, and others. Is it possible to determine, solely from the sequenced DNA or from known bone ...
3
votes
1answer
50 views

Estimating RPM to RCF in Methods from Older Papers

I'm attempting to replicate a cell biology method from a 1958 Laboratory Investigation paper. The protocol is for the isolation of an extracellular matrix protein, and a key step is a centrifugation ...
4
votes
1answer
2k views

Bug Identification: Is this small tubular, black bug a bed bug?

So I found this tiny bug on my wall in the bedroom of my apartment. I estimate it is about 3mm long by 1mm wide. Is it a bed bug? It does not seem to match any of the pictures I've seen online. ...
0
votes
0answers
35 views

Maximum heart rate increase/decrease while physically active [duplicate]

I'm a computer scientist and implementing a heart-rate monitor for physical exercise. While I try to improve my code, I stumbled over the question how fast the heart rate can change within a given ...
8
votes
1answer
217 views

How are bones growing, if bones are not connected to the brain?

If the bones are not connected to the brain, how is their growth controlled? This question is not a duplicate of the question Mechanisms of bone growth, as this question deals with how bone growth is ...
3
votes
1answer
666 views

Why do small fonts strain the eyes?

I understand that too much close reading will strain the ciliary muscles of the eyes. But what about small fonts? The contraction of the ciliary muscles is dependent on the distance not font size. In ...
5
votes
3answers
343 views

Studying effects of alcohol on cells

I am wondering about the logistics of a simple experiment with say 3 types of alcohols, and various concentrations of each, with a control(s) I would like to research the effects of alcohol on ...
4
votes
1answer
210 views

Why are most transcription factors enhancing the expression rather than repressing?

One can classify the effects of Transcription Factors (TF) on gene expression into two types: it either enhance or repress the gene expression. I have always been told that most of transcription ...
0
votes
0answers
51 views

How can site-directed mutagenesis be used to suppress the production of anti-antibodies?

In a previous post of mine, I asked how to supress the creation of anti-antibodies in vivo. In the answer, it was mentioned that site-directed mutagenesis could be used. Currently, I can't find mcuh ...
3
votes
1answer
77 views

Well to well variation in thermal cycler fluorescence?

We have an old BioRad ICycler Thermal Cycler with MyIQ single color fluorescent detector. While it's meant for RT-PCR, we've been using it for melt curves and binding assays for different types of RNA ...
7
votes
1answer
161 views

Number of transcription factor genes in the human genome

What is the number of the transcription factor genes present in the human genome? Does this value differ compared to Mus musculus, Drosophila melanogaster, Arabidopsis thaliana, C. elegans and S. ...
3
votes
1answer
166 views

How to attract spiders to my house?

I've been living in my apartment for a year now, and noticed something lately. During spring and summer I have quite a lot of midges indoors, and even now there are some. But there are no spiders! So ...
2
votes
0answers
19 views

Resource for finding Repressive/Inhibitory factors for a given gene?

I have a list of genes for each of which I'd like to find: A list of transcription factors that up-regulate the gene A list of inhibitory factors that down-regulate it. I used this tool on ...
0
votes
1answer
48 views

Effect of Western chicken and GH [closed]

I heard this clause from my teacher one week ago: Chicken are grown in half a year until eaten in Baltic countries - Estonia, Latvia and Lithuania, for instance, [probably in other parts of ...
0
votes
1answer
3k views

Can swallowed fingermails, hair, or skin get caught in your appendix? [closed]

There is a common saying in my place: If you eat your skin, hair or nails, it will be deposited in the cecal (Vermiform) appendix, and can cause appendicitis. (This is mostly told to children to ...
13
votes
4answers
12k views
+50

Why deoxyribose for DNA and ribose for RNA?

Why is DNA made out of deoxyribose and RNA made of ribose? Why can't they both use ribose or deoxyribose? I think that the deoxyribose gives an advantage in storing genes, the job of DNA and ribose is ...
11
votes
1answer
3k views

Why don't McDonald's fries decompose?

So I was cleaning out my car and found a McDonalds French fry. as I don't eat anything in my car I know exactly who and when this fry is a result of. The when is + 10 months old and it could pass off ...
6
votes
1answer
839 views

Why does DNA have its name?

Why is DNA called deoxyribonucleic acid and not something else? I get the nucleic acid part (because that's what DNA is made of) but what about the deoxyribo- part, especially the ribo- part. Maybe ...
1
vote
0answers
28 views

Would biotechnology in agriculture actually decrease biodiversity, as many people say? Does it have to?

I've heard the claim that because farmers would be using the same seed, you would end up with an entire crop population that could be susceptible to a disease. Like if you had a diverse population of ...
2
votes
3answers
196 views

fastq-dump using mkfifo to stream data

So, fastq-dump has the ability to be run on just an SRA file accession number, such that the SRA is converted to FASTQ on-the-fly, and the SRA doesn't have to be written to disk. I'm curious whether ...
3
votes
1answer
72 views

Western blot alternatives

Given an in vivo sample from an experimental infection, I would like to see if a bacterial protein is present. I've been thinking about Western Blot using sera from animals infected with the ...
1
vote
0answers
33 views

Public Pacemaker database online?

I am looking for any database about pacemakers with the leads atria A right ventricle VR left ventricle VL I did not find any in Physionet. Is there any anonymous data about different ...
5
votes
5answers
96 views

Can an influenza virus carry other infectors with it?

This idea came to my mind when thinking about how many people become ill in many locations with similar symptoms (fever and rough cough) from Influenza. There are of course different types of ...
6
votes
3answers
6k views

Should I dilute DNA with water or elution buffer?

I've extracted DNA using a kit and final step is eluted with buffer. If I must dilute my DNA samples, do I use the same elution buffer or can I use milliq water?
1
vote
0answers
52 views

Cigarette consumption dose-response function WRT health outcomes

I'm curious how health risks (mortality, lifetime probability of cancer, etc) change with cigarette consumption. Specifically, treatring cigarette consumption like a continuous variable, rather than ...
1
vote
0answers
124 views

How does air-liquid interface (ALI) culture work?

For studying diseases, such as chronic obstructive pulmonary disease (COPD), cells are often grown in air liquid interface. I understand that the common way of establishing this these days is to grow ...
1
vote
0answers
21 views

Terrestrial Vertebrate Limbs

This question is regarding the conversation that took place here: Why don't mammals have more than 4 limbs?. I'm not sure if someone mentioned this and I just missed it, but everyone is talking ...
4
votes
2answers
659 views

Why do we have to exhale (or inhale) in order to speak?

Every time we speak, sing, or make any other kind of advanced noise with our throats, we exhale, or to put it that way, blow air through our throats. Why is this required? After all, speakers do not ...
1
vote
1answer
114 views

Are more animal species edible than plants?

While grocery shopping I was thinking that we restrict ourselves in regard to which animals we eat. I surely don't want to eat spiders and ants, for example, but I know that this is just because of my ...
4
votes
1answer
133 views

Why estimate linear and full (linear, quadratic, and correlational) selection coefficients separately?

"We then fitted a linear regression including all three life-history traits to estimate the vector of linear selection gradients, β, for each sex (Lande and Arnold 1983). A quadratic regression ...
3
votes
2answers
81 views

Hydrophobia Outside of Rabies?

RELATED: Why does rabies cause hydrophobia? Agony, Hydrophobia and viruses in the light of evolutionary principles Has hydrophobia been found outside of rabies? I have only seen it ...
1
vote
1answer
42 views

Deeper Learning in Physiology? [closed]

I am a Pharmacology and Toxicology major at a large state school. I was only required to take physics I and II. (algebra based) At first I thought that was fine, but I soon began to realize that I ...
3
votes
1answer
92 views

Is this a carpenter ant?

I stumbled upon a few hundred of these swarming around two different places in my living room today. They kind of look like a carpenter ant to me, but I'm not sure. Also, I'd love to know how you ...
2
votes
3answers
2k views

Long term storage of agarose-ethidium bromide gels that have already been cast

I have come up with what I thought was a clever idea: Store the agarose gels I pour, and only cut as many lanes as I need to run later, minimizing wasted agarose (and wasted effort/time) when I need ...
4
votes
0answers
154 views

Long-term effects of antihistamines on mind and CNS [closed]

Can maybe someone share knowledge or guesses on the following questions: Does the prolonged use of antihistamines cause long-term effects on mind or CNS? Are there any known evidences of their ...
1
vote
1answer
143 views

Does physical exercise following lack of sleep increase the risk of sudden cardiac death (SCD)?

Is there any scientific evidence supporting the hypothesis that physical exercise following lack of sleep increases the risk of sudden cardiac death (SCD)? The only relevant research I could find is: ...
1
vote
2answers
51 views

Why are nausea and dizziness such common side effects from medication?

Why are nausea and dizziness such common side effects from medication? If you go through your medicine cabinet and look at side effects, those might just be on every single bottle. Is there some ...
8
votes
2answers
213 views

How was the resemblance between apes and humans explained in pre-Darwinian biology?

Humans and apes have somewhat obvious similarities, these must have been apparent to natural philosophers before the possibility of a common ancestry was first proposed in the mid-1800's. These ...
4
votes
1answer
1k views

How long does it take for a cricket to die at subzero temperatures?

I am on a number of reptile groups and I often hear freezing recommended as a humane way to get rid of surplus feeder insects. However, they can also revive if you don't leave them in there long ...
2
votes
1answer
1k views

What percent of the population has some form of synesthesia?

Data I am trying to get my hands on: What types of synesthesia (e.g. Grapheme-color synesthesia, Chromesthesia, etc.) are most common across the population? What percent of population has that ...
0
votes
1answer
47 views

PCR cycle problem [closed]

IF I began a PCR cycle with 5 copies of a particular DNA section, and copied the section by PCR, for 6 cycles, how many copies of the DNA (include the originals) would I have by the end of these ...
2
votes
1answer
97 views

Neuron Growth and Regeneration

Are nerves and/or neurons able to grow and repair after damage, but not regenerate? Is this specific to humans? I have heard of people being paralyzed, but after much therapy are able to use their ...
8
votes
1answer
1k views

How does the cornea breathe during sleep?

The cornea is not supplied with blood vessels and so exchanges gases directly with the atmosphere. So how does it breathe during sleep when our eyes are closed?
7
votes
2answers
8k views

Why should plants transform glucose into sucrose before transporting it to other parts?

I've learned that plants transform glucose into sucrose before sending it into phloem. But the process seems to be complex and energy comsuming. Why should plants do it? Is it really necessary?
3
votes
1answer
52 views

Prevent biofilm formation on moist surfaces

I have an indoor fountain with lots of water. What are the most common microorganisms in this kind of moist environment, and what are the standard way to prevent biofilm formation by them? I thought ...

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