2
votes
1answer
40 views

How is insulin transported in vivo in mammals?

What is the mechanism for transport of insulin in mammalian cells?
5
votes
1answer
3k views

What's the minimum distance of focus for the lens of a human eye to reach maximum flatness?

According to the Wikipedia article on eye accomodation, the range in which a human eye can focus is from 7 centimetres away up to essentially an infinite distance. Of course, people can't see things ...
2
votes
1answer
42 views

Activity of glucokinase

From Solomon et al, 2013 ACC Synthetic biology and from this video : Here, there are 2 competing reactions for glucose - one with glk as enzyme and other with gdh as enzyme. In the graph, y axis ...
2
votes
1answer
129 views

how do they identify different protein chains?

Can someone please explain how different protein chains occur exactly? I'm not talking about the side chain, but the protein chain which is typically labelled as A,B,C etc in the PDB. I'm curious as ...
4
votes
1answer
71 views

Can P. falciparum and other malaria parasites be cultured and genetically engineered?

I'm not a parasitologist, and I was wondering about the current state of malaria research. For instance, is it possible to culture P. falciparum? Are there techniques for genetic manipulation, editing ...
1
vote
3answers
228 views

If everybody DNA is different then how blood can match even with matching blood group?

We know that everybody's DNA pattern is different in the world. Then how can ´we transfer blood from one person to another person and this person can survive ?
3
votes
1answer
2k views

What is the standing genetic variation?

I am reading this review. In the first part, the author introduces Standing Genetic Variation, described as: STANDING GENETIC VARIATION Allelic variation that is currently segregating within a ...
1
vote
3answers
161 views

Are there tools for automatically parsing glycan names into tree structures?

My colleague and I are working on a project involving data produced at a glycan microarray facility. The array data that came back to us were a list of glycan names (in IUPAC condensed format). We ...
3
votes
1answer
85 views

Functioning of BCG vaccine

I read (from Nature Volume507, S4–S7 (06 March 2014) : For reasons that are poorly understood, BCG protects only infants; it is ineffective in older children and adults. Its efficacy also ...
1
vote
1answer
248 views

What is the blood ejection speed outward from human body vein? [closed]

At what height blood can eject from human vein ? I see, sometime there is direct blood transfer from one person to patient. So sometime blood bottle is kept at certain height and blood is transfered ...
1
vote
0answers
74 views

How do cellphones calculate heart rate?

How do cellphones calculate heart rate ? I understand that the cameras there try to count undulation in blood flow, but is the method of calculation same as that of professional SpO2 monitors ?
2
votes
0answers
64 views

How did the roar evolve from snort?

When Lions roar, or Dogs show aggression, they do that snort-roar thing. They're producing sound while inhaling. How did that come to be when all (?) other forms of sound involve exhaling? Humans do ...
3
votes
0answers
93 views

Data analysis of transcriptome sequencing data [closed]

I want to learn more about the data analysis and statistics on transcriptome sequencing data. I would like to read some important papers of the field and books and maybe some MOOCS, if they are ...
1
vote
1answer
2k views

Difference between inbreeding and interbreeding

Is inbreeding the same as interbreeding? On this site interbreeding is defined as (http://www.thefreedictionary.com/interbreeding): To breed with another kind or species; hybridize. To breed ...
2
votes
1answer
38 views

Evolutionary rationale behind migration proteins

Tumor cells are able to migrate due to specific migration proteins. What is their evolutionary origin? Or are they simply deregulated?
4
votes
1answer
8k views

NaCl role in CTAB - DNA complex in DNA extraction

I have a question about the role of NaCl in the DNA extraction process. So for NaCl concentrations under 0.5M, CTAB and DNA molecules can create complexes. In those concentrations, proteins and other ...
3
votes
3answers
240 views

How quickly is antibiotic resistance lost?

I would imagine the bacterial genome is highly conserved and limited in its space, but maybe I am wrong. If you were to take a strain of antibiotic resistant bacteria and kept them isolated, but fed ...
0
votes
2answers
1k views

What is the difference between fibrogenesis and fibrosis?

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. I used the word "fibrogenesis" as the outcome of acute inflammation (healing). ...
3
votes
0answers
185 views

Gibson assembly using NeBuilder

I am supposed to construct a plasmid that contains features from two other plasmids. My strategy is to generate three fragments form the two other plasmids. I was encouraged to try Gibson assembly, ...
2
votes
2answers
58 views

Functioning of BRCA2

I know that BRCA2 interacts with RAD51 to repair DNA damage. But how exactly does it function ? What are the other proteins that interact with it ?
7
votes
2answers
2k views

Can a carnivorous animal consume plants with no adverse effects?

While I know that in nature, carnivorous animals are poorly suited to eat plants (largely due to having sharp teeth, not grinding teeth, as far as I know), I was wondering if, in an emergency ...
0
votes
1answer
24 views

Can pulmonary infarction be asymptomatic?

I think it can because there are many parts in lungs. Like for some COPD patients. However, I am not sure if COPD patients can have infarction. Lungs have parallel circulation. Red infarct is ...
1
vote
1answer
262 views

The distance the electromagnetic field of the heart can be detected

A very smart friend of mine seems to get taken in by junk science. He started telling me last night that the electromagnetic field of the heart can be detected beyond 30 feet. What is the actual ...
2
votes
2answers
474 views

pI and pH relationship in context of ion exchange protein purification

I am confused about relationship between isoelectric point and pH in context of ion exchange protein purification. Why we cannot use this method for protein with pI below 7? Thank you very much for ...
0
votes
1answer
27 views

Association of shorter telomeres with heart disease

From this paper Those with shorter telomeres in blood DNA had poorer survival, attributable in part to a 3.18-fold higher mortality rate from heart disease (95% CI 1(.)36-7.45, p=0.0079), and ...
4
votes
1answer
376 views

Sexual Differentiation in Monoecious plants with unisexual flowers

In monoecious plants having unisexual flowers (eg Zea Mays, Ricinus Communis etc), there must be some mechanism as to produce two sexually distinct flowers from the same genotype. Since both the type ...
2
votes
1answer
170 views

What is this plant?

I really like this plant--I'm just wondering what its name is (perhaps genus+species). I think this plant grows in the tropical rainforest in Malaysia. Any suggestions? Thanks!
0
votes
1answer
28 views

Why violets die in closed space?

I'm going to engage into making florariums (a garden in the bottle). I've heard, that violets die in closed space. Do anyone have an idea, what is the reason for that? Lack of oxygen or CO2 or ...
2
votes
2answers
171 views

Can a fungus become resistant to a chemical such as Potassium Permanganate?

A friend used potassium permanganate solution to treat tinea on the hands/feet but after some initial success, the tinea seems to be making a comeback. Could the fungus develop resistance to potassium ...
3
votes
1answer
63 views

How can I re-format my DNA motifs' position weight matrices?

I am working with a set of DNA motifs that are predicted as potential regulatory motifs (e.g. transcription factor binding sites). The motifs belong to several species, and I wanted to cluster these ...
2
votes
3answers
135 views

Real-time PCR result interpretation

I performed real-time PCR and I was looking for expression fold changes for 2 genes and I had two sample pools, one treated and the other not treated (for each gene). The problem is that my ...
0
votes
1answer
418 views

Pathogenesis of Chronic Venous Congestion in Lungs?

I am thinking how CVC in lungs lead to the left-sided heart failure.
3
votes
1answer
200 views

What insect is this..?

Can anyone tell me what kind of insect (if it is one) is this...!! Or is it the pupa of some insect? Well I don't think that the whole big thing is the insect itself, it appears to be just a kind of ...
1
vote
1answer
116 views

What is the pathogenuc mechanism of brown pigment lipofuscin in muscle atrophy?

I think it is autophagy. Lysosomal degradation. Autophagocytosis. Example of the brown pigment (lipofuscin) here: I am not sure if autophagy is the right answer to the "pathogenic" mechanism of ...
0
votes
1answer
76 views

Pathogenesis of chronic venous congestion in skin?

I think CVC cannot lead to heart failure primarily. So let's think its pathogenesis in skin now only. I think the pathogenesis is like this dilation of veins and capillaries due to impaired venous ...
3
votes
4answers
83 views

Can systemic intravascular thrombosis cause brain infarction?

I wonder if the thrombus can pass through the brain-blood barrier because I think small molecules like O2, CO2 and ethanol can pass it. Probably, in some diseases where the permeability of the barrier ...
0
votes
1answer
92 views

Dimensional analysis Question

So I'm new to the dimensional analysis world and I'm little confused and the answers I'm getting are not convincing :( if the concentration of hemoglobin in a 5ml sample of blood is 34 g/dL. and red ...
0
votes
2answers
166 views

What errors can occur during DNA replication?

When there is an error in copying DNA (a mutation), what exactly goes wrong? If G goes with C and A goes with T, I don't see how that part can mess up. Is the idea that when the double helix is ...
3
votes
1answer
87 views

Hela live cell confocal laser scanning - reccommendations for good fluorophore that will show good movement

I've been doing a lot of live cell imaging lately mostly using hela cells expressing some EYFP based chimeric proteins. I'm building a video library for an art student here at the university who is ...
2
votes
2answers
410 views

How much of your stock solution should you take to make the 1000 cells/mL mixture? [closed]

You need a solution containing 1000 buccal cells/mL. You count that you have 125 buccal cells in 50uL, from a total solution of 8 mL. How much of your stock solution should you take to make the 1000 ...
1
vote
1answer
38 views

Which inflammatory response with Cytomegalovirus infection?

I am thinking about inflammation process with Cytomegalovirus infection. I first thought it is about chronic inflammation, but then changed my mind because of virus infection. I think cytokines must ...
2
votes
1answer
40 views

Neuroscience: zapping an axon connected to thermoreceptor

Let’s say an experimenter has an electrode that can give a shock to a single axon. She takes that electrode and zaps an axon connected to thermoreceptors in the hand of her subject. I) What would the ...
3
votes
1answer
62 views

spinal cord lesion and result in somatic sensation

Jimbo suffers a lesion to the entire right half of the spinal cord at the T6 level. A few weeks after his injury, his doctor tests his right and left legs for somatic sensation and tone. fill out her ...
3
votes
1answer
54 views

What stops telomerase?

The telomerase is an enzyme that adds telomeres. What stops the telomerase from adding too many telomere sequences ? What's the regulating mechanism ?
1
vote
1answer
23 views

2 types of telomerases?

As telomerase works by adding new nucleotides complementary to the RNA it contains, it cannot work for the complementary strand. Say telomerase X has RNA complementary to the 5' to 3' strand it ...
4
votes
1answer
37 views

Telomerase in tetrahymena

In this amazing video, at 26:03 we see this image We now know that the telomerase contains a sequence complementary to the telomere sequence and so is able to do what it is capable of doing in this ...
1
vote
2answers
156 views

Conserved proteins are non immunogenic

I read that proteins that have been highly conserved are non-immunogenic. Why is it so ? What is the special thing that makes it non immunogenic(antibodies against them are hard to make) ?
2
votes
1answer
129 views

Meaning of the word Oleracea

What does "oleracea", as appears in numerous plant species (scientific) names, mean? Examples: Euterpa oleracea, Brassica oleracea, Portulaca oleracea, Acmella oleracea, Spilanthes oleracea.
1
vote
0answers
64 views

College Bio Research: Bacteria found on computer keyboards. [closed]

I am a college students brainstorming ideas on different topics that may be appropriate for on-campus research. What I came up with and I would like to give it a try is analyze the different types of ...
4
votes
1answer
158 views

How to calculate the effective population size ($N_e$) with overlapping generations?

From this Source: If generations are overlapping, then the effective population size $N_e$ does not equal the population size $N$. I know mathematical formulations in order to find the effective ...

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