5
votes
1answer
88 views

Resource for model organism anatomy/physiology for biological experiments

I'm looking for a resource that best surveys the anatomy and physiology of common genetic model organisms, and how their characteristics are particularly useful for biological experiments. For ...
3
votes
0answers
44 views

Are all Autoreceptors Downregulated by their Respective Endogenous Ligands?

I know that the 5-HT1A and $\alpha$2 adrenoreceptors receptors serve as autoreceptors for serotonin (5-HT) and norepinephrine respectively and are down-regulated by repeat exposure to their respective ...
6
votes
1answer
479 views

Why do antidepressants have a delayed onset of action?

Why do antidepressants take so long to reach efficacy? I've read of theories about it perhaps being due to the strength of negative feedback via serotonergic and adrenergic autoreceptors during the ...
4
votes
1answer
373 views

Why am I getting low transformation efficiency with DB3.1 E.coli cells?

I am making competent cells using DB3.1 E. coli cells. Even after following the exact protocol (Inoue method for ultracompetent cells) given in 'Sambrook and Russel', I am not getting transformation ...
8
votes
2answers
154 views

How can a three-base codon evolve from a two-base codon?

Inspired by this question among others. It's widely suggested that the current 3-base codon system of encoding protein sequences in DNA evolved from an earlier 2-base codon system. This makes sense ...
3
votes
1answer
155 views

Which Receptors are Involved in the antidepressant effects of SSRIs?

From what I've read the major receptor subtypes involved in the antidepressant effects of SSRIs are: 5-HT1A 5-HT2C 5-HT3 5-HT6 Please cite journal articles to back up your claims, I don't want any ...
2
votes
1answer
144 views

Why do genitals feel frozen when freefalling?

I don't want to add much more about that. Since childhood I noticed a chilling effect, even when doing rollercoaster-type activities.
4
votes
1answer
52 views

How does Serotonergic (5-HT2A mediated) Psychedelia work?

How does serotonergic (5-HT2A specific) psychedelia work? I've read that there are some theories that it might involve the induction of a glutamate release in certain regions of the brain involved in ...
2
votes
1answer
95 views

Colloids in digestion

I am looking for examples of colloids involved in digestion for a cross-curricular (bio-chem-physics) lesson plan. Although I have found references implicating colloids in both lipid and protein ...
3
votes
2answers
1k views

Why do some animals have 8 Limbs (e.g. Spiders, Octopuses)?

Octopuses have 8 tentacles, spiders have 8 legs. Is there something special about 8? It seems like an animal that needs 360° mobility has 8 legs.
4
votes
1answer
476 views

How does the eugeroic modafinil work?

How does the drug, modafinil (Provigil), exert its eugeroic (wakefulness-promoting) effects? I've read that it works by increasing dopamine and histamine concentrations in the CNS and by serving as a ...
2
votes
1answer
128 views

Do SSRIs downregulate or upregulate the 5-HT3 receptor?

What effect do SSRIs have on the expression of the ligand-gated ion channel, the 5-HT3 receptor?
3
votes
0answers
74 views

Microscopy Book Suggestions

I've learned programming through great book recommendations, many from the Stack Exchange series of sites. I'm hoping to take this approach to gaining a fundamental understanding of how fluorescence ...
11
votes
3answers
925 views

Mathematical Modelling of Natural Selection

I'm a math undergrad looking for some papers on modelling the process of natural selection. The only paper I've been able to find is by the pre-eminent mathematician Herbert Wilf from 2010, There's ...
2
votes
0answers
37 views

Which of the nicotinic acetylcholine receptors (nAChRs) catalyse the release of the neuromodulators mentioned below that's caused by nicotine?

Neuromodulators: acetylcholine, norepinephrine, epinephrine, vasopressin, histamine, arginine, serotonin, dopamine, autocrine agents, and $\beta$-endorphin. I am aware that agonists of the $\alpha_7 ...
16
votes
2answers
4k views

How many organisms have ever lived on Earth?

I've looked for some information on this, but couldn't find anything useful. Has there been any noteworthy attempt to estimate the sum amount of individuals of all species that have ever lived on ...
5
votes
1answer
896 views

Is human face more resistant to cold than other body parts?

Walking outside tonight in -15˚C I realized an interesting observation: While I felt cold on most part of my body, my face (although the only uncovered part) didn't really feel cold. It registered the ...
7
votes
3answers
11k views

Why are 3 nucleotides used as codons for amino-acid mapping in DNA?

DNA is made of 4 unique nucleotides. When coding for a protein, a sequence of 3 nucleotides is used to code for each amino acid. Why are codons 3 nucleotides in length? A related question can be ...
8
votes
1answer
255 views

What prevents a pregnant woman's immune system from recognizing her fetus as nonself (and attacking)?

I'm familiar with the scenario of Rh- mother with Rh+ fetus having complications (more so after her first child), but that's not what I'm curious about. I want to know mechanistically why a pregnant ...
8
votes
0answers
142 views

Do mammals develop tolerance to anticholinergics?

I know that first generation H1 antagonists, commonly known as antihistamines have anticholinergic effects. Their sedative side effects go away due to tolerance, but as for their anticholinergic side ...
14
votes
1answer
430 views

Fibonacci sequence in nature, truth or just wishful thinking?

I'm reading a bit on the Fibonacci sequence in nature, be it the golden ratio or the golden spiral forming over and over again in biological structures, and then I came across this online article by ...
5
votes
1answer
149 views

functional hypocholesterolemia due to very high HDL or low LDL?

Nutritional and medical recommendations about cholesterol seem to focus exclusively on hypercholesterolemia, and as such, they provide only a maximum desirable level for LDL and a minimum for HDL. ...
5
votes
1answer
86 views

Is there a scientific proof that smoking spoils face skin?

I saw that cigarettes-smokers (more than 3 cigarettes per day) often have the skin of the face which is a little bit spoiled. Is there any scientific proof that cigarette smoke (or the nicotine ...
4
votes
2answers
356 views

Extraretinal photoreception in mammals? [duplicate]

A Finnish firm Valkee sells light-ear-plugs against thing such as jetlag. I asked a researcher in Aalto university how do they really work and he responded ...
5
votes
1answer
149 views

Can in the case of multiple sclerosis (MS), a too high osmotic pressure in the nerve, lead to a high intracellular concentration of potassium?

Can in the case of multiple sclerosis (MS), a too high osmotic pressure in the nerve, lead to a high intracellular concentration of potassium, and also lead to 'pumping up' of nerve cells, which then ...
23
votes
6answers
7k views

Why is cold water more refreshing than warm water?

Obviously, the temperature of water does not affect its chemical composition. At least not in the ranges we are likely to drink it in. Yet it is clearly far more pleasant and refreshing to drink cool ...
6
votes
1answer
136 views

Long term effects of “brain freeze” on the cerebral vasculature

According to one theory, ice cream headaches are caused by an increase in blood volume of the anterior cerebral artery: Another theory into the cause of ice-cream headaches is explained by ...
4
votes
1answer
59 views

Is copy number variation dynamic?

Is there any evidence showing that copy number variation changes over time? I'm wanting to model interactions in expression level as a dynamic bayesian network, but an assumption my approach will need ...
2
votes
1answer
249 views

Why do marine animals have fins?

Why do Marine animals have fins.
8
votes
3answers
436 views

Why people like to see pornographic scenes, but do not feel the same about eating scenes?

This question may seem funny, but I think biology must have good answers. I think no more explanation is needed. I really thought about this and searched for an answer, but there is nothing yet. If ...
5
votes
2answers
65 views

Prostaglandin F2-alpha production in men

I am trying to find information on Prostaglandin F2-alpha, specificaly production in men. Could somebody explain how this prostaglandin is produced? What types of cells are producing it, production ...
2
votes
1answer
453 views

Where does Taq polymerase migrate during electrophoresis?

Assuming a 1% Agarose gel with TAE. Follow up questions: Is there a way to stain for it? Could the polymerase be captured and reused?
4
votes
1answer
249 views

Is DNA green viewer carcinogenic?

I use DNA green viewer in Lab to see DNA and RNA bands. Some peers told me it is carcinogenic and is not safe. Is this correct? If yes, are there better choices to use in working with gel?
11
votes
3answers
3k views

Why do red blood cells contain haemoglobin and not myoglobin?

So I am reading about muscles and I come across myoglobin. It has a much higher affinity for oxygen than haemoglobin. So why have animals evolved to have haemoglobin in red blood cells, rather than ...
6
votes
1answer
186 views

Are all chromosomes equally susceptible to mutation?

The humans have been around for a few million years, other organisms longer yet. Changes that occur in the genome and propagate (may) eventually throw a new species ... or atleast branch off the old ...
5
votes
1answer
1k views

What is the fiber axis in the Watson and Crick paper?

I was reading Watson and Crick's article on DNA structure, and the diagram on the lower left of the first page had something called the fiber axis going through the DNA. This axis isn't in modern ...
2
votes
1answer
155 views

How to determine the direction of regulation of a gene by comparing gene expressions?

I am just learning about the gene expressions and regulation. Several researches focus on finding the genes of altered gene expressions on a microarray to claim that they have a correlation to a ...
16
votes
4answers
3k views

Why is the Hydra Biologically Immortal?

I have heard that the Hydra organism is biologically immortal (later I found that there are more immortal organisms). Now I know that its immortality is related to its telomerase. The thing is that we ...
4
votes
1answer
41 views

Effect of Ethanol on Brain Volume Measurements

I want to compare the brain sizes of two populations of fish. However, all the samples I have were fixed in 95% ethanol. As far as I know, 4% formalin is the normal fixative for soft tissues. Can I ...
4
votes
1answer
469 views

How does toluene inhalation damage the brain?

We just had a discussion about toluene abuse. It is known, that people inhaling toluene for a long time have significant brain damage, including decreased intelligence. I found that toluene is a ...
1
vote
2answers
235 views

Why can silicone reduce keloid?

I heard people use silicone sheet for reducing raised scars (i.e., keloids). I was wondering what is the rational behind it, and whether it actually works.
5
votes
1answer
384 views

Why do humans alone have the capability to have religious/spiritual experiences?

What is it in our brain that makes having such experiences possible? I assume other species don't have these. Sure there are instances in the natural world where you can see individuals of the species ...
5
votes
2answers
2k views

Why does yawning impair hearing?

When I yawn I can't hear anything happening around me. I also feel some kind of muscles inside my head contract and hear a faint hum, but it is not loud enough to explain not hearing other sounds. I ...
3
votes
4answers
1k views

Refutation of Darwin's Random Evolution Theory [closed]

I saw this refutation online of Darwin's Random Evolution Theory and cannot see any holes with the logic. Can anyone crack this simple refutation? Refutation of the Theory of Random Evolution ...
3
votes
1answer
207 views

Is this an Emperor Penguin or a King Penguin?

I have a book from Dorling Kindersley called Animal Encyclopedia (the German version that I have is called Das große Tierlexikon) with images from animals. One is titled Emperor Penguin ...
2
votes
1answer
3k views

Which blood vessel carries the most impure blood?

There is a question in my Biology textbook: "Which blood vessel in the human body carries most impure blood after few hours of meal." The answer is given as Renal artery. But I think the ...
8
votes
1answer
374 views

Has any large-scale origin-of-life simulation/experiment been done?

I have been thinking a little about the origins of life, and was further inspired by this question: How did the first self replicating organism come into existence? I can accept that we don't quite ...
2
votes
1answer
581 views

What is the surface area of the human heart?

I heard that the human heart had a surface area of 1000 square feet, and I thought that that cannot be true. So what is the surface area of the human heart and what are the different ways it can be ...
8
votes
3answers
6k views

Why does having cold hands hurt?

(1). Why does having cold hands create a painful sensation? Is it a physical effect, maybe a protection mechanism from evolution? (2). Why, if one's hands are cold, does it feel as if they are more ...
3
votes
0answers
102 views

What are the physiological effects of wine?

I have read that alcohol in general and wine in particular can have advantageous as well as detrimental effects on human health. Is this true? What are the physiological effects of consuming wine in ...

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