3
votes
0answers
79 views

Experimental techniques to measure protein-protein and protein-ligand structure and dynamics

We would like to compare our simulation results with experimentation. When one wants to follow experimentally the dynamics (and possibly structure) of protein-protein or protein-ligand docking ...
5
votes
2answers
810 views

Why does squinting allow you to see objects more clearly?

How does squinting alllow one to see clearer pictures? What are the harmful effects?
0
votes
1answer
352 views

Why is offspring of identical twins not identical?

When identical twins marry identical twins, the children of the couples will be full genetic siblings but why are they not genetically identical?
7
votes
1answer
1k views

What really happens when a body is tired?

This may be anecdotal; please feel free to vote to close. After staying awake for an extended duration, I usually find myself having to take extra effort to focus my eyes on an object. Similarly ...
9
votes
1answer
469 views

Does DNA react in all of the ways most other acids do?

As I understand it from my basic chemistry, there are some fundamental reactions that exist between any acid and other substances for example acid-base reactions that form a salt, and the existence of ...
2
votes
1answer
160 views

Can epigenetic changes affect reproductive success?

This is prompted by niallhaslam's answer to this question [Since Darwinian times, has there been any striking/notable effects of evolution on humans?]. A comment by Alan Boyd asks whether epigenetic ...
2
votes
1answer
58 views

Biology view on trait variability

In reading the annotated Origin... I have come to the following note by Costa on p. 168: Again, modern biologists would disagree with Darwin's idea that especially well-developed traits vary to a ...
2
votes
1answer
50 views

What is the title of Darwin's paper on cellular structure?

I read somewhere that Darwin wrote a paper that dealt with cellular structure, but I've been unable to find the title or contents of the paper because Darwin wrote such a volume of material. What is ...
5
votes
2answers
94 views

Average number of gene products in (a) eukaryote(s)

Due to alternative RNA splicing, it isn't uncommon to ultimately find multiple gene products expressed from one gene in eukaryotes. I'm looking for a reference value for the average number of final ...
2
votes
1answer
87 views

Tubing connector identification request

this may not be on topic but I'm hoping someone here can tell me the name/manufacturer of the connectors used with the thin teflon tubing in this picture:
3
votes
0answers
59 views

Patch-Clamping Neurons Resources [closed]

Are there any lectures available on Patch-Clamping? Were can I find a mathematical model of Patch-Clamp? (that can be easily implemented in matlab). I have found some step-by-step protocols on ...
4
votes
3answers
181 views

Since Darwinian times, has there been any striking/notable effects of evolution on humans?

I understand that evolution is constant process that acts on a population in successive generations. Thus, it is obvious that evolution is happening. However, I'm curious as to the stricking examples ...
2
votes
1answer
47 views

Similarities Between Cells?

Which of the following are usually identical between a lung cell and a brain cell, from the same person, assuming that they are normal (non-cancerous) cells? Circle your choice(s). ...
3
votes
2answers
4k views

Is there an evolutionary reason for the 5 electron transport complexes in plants and animals?

The electron transport chains of both the light reactions of photosynthesis (in plants) and oxidative phosphorylation (in animals) both contain 5 complexes including ATP synthase, as shown below. ...
2
votes
2answers
367 views

Translate DNA to Protein

Assuming the sequence shown is read left to right, what is the sequence of the protein produced? sequence: 5’-ATGTACTTCCATCTGGAATAG-3’ MY ATTEMPT: I know RNA is synthesized 5 to 3. This is ...
2
votes
2answers
127 views

Is it more likely that the very first living organisms had a linear genome?

Is it right to assume that the first living organisms on earth had a linear genome? I base this on the fact that linear macromolecules are clearly much more common in nature that circular ones. To be ...
4
votes
1answer
38 views

Are there any strictly chloroplast/mitochondrion-residing ribozymes?

A simple question that had occurred to me. Considering the small doubt of transcribed genes in both organelles, I would doubt it, but are there any known ribozymes strictly found in either ...
2
votes
1answer
57 views

Preserved alpha complementation over evolutionary time?

Has the result of alpha-complementation ever happened via mutation through evolutionary time, and been preserved in modern day organisms? In other words, has a functional gene product ever been split ...
5
votes
1answer
290 views

Which way to run BLAST?

I have a set of scaffolds from a genome assembly, and I want to align a collection of proteins from various species to it. I can do this using BLAST in two ways: Create a BLAST database of the ...
6
votes
1answer
219 views

Is it possible to increase lifespan through controlled evolution?

A few years back when I was reading The Selfish Gene by Richard Dawkins, there's this short passage where he theorizes about a way to achieve an increased lifespan through controlled evolution. The ...
7
votes
2answers
2k views

Multi-nucleated cells: advantages and examples?

This question arises because I saw that monocytes and leukocytes are commonly called 'mononuclear cells' in the scientific literature. The implication of course being that other immune sub-types are ...
5
votes
1answer
174 views

Why was polyploidy not lethal in certain octodontid rodents?

As discussed in Why is polyploidy lethal for some organisms while for others is not?, polyploidy is normally lethal in mammals. However, two species of Octodontidae (South American rodents), are ...
3
votes
1answer
74 views

Brain response frequencies while sleeping

I'm not sure if this is the right place to ask this but Biology seemed to fit best. I'm trying to find out what frequencies the brain responds to best while sleeping. The reason for this is recently ...
2
votes
1answer
57 views

methods for targetted deletion of genomic regions?

I would like to know what are currently used methods for targeted deletion of genomic regions in mammalian organisms or cell lines. I have heard of Zinc-Finger nucleases as a recent genetic ...
6
votes
2answers
623 views

How do cells “know” what “type” to differentiate into?

I have been reading about Townes and Holtfreter's work in 1955, in which cells are dissociated from a blastocyst in an alkaline solution then mixed together and spontaneously reaggregates based on ...
9
votes
3answers
132 views

Adipocyte Density

People who are overweight and wish to lose weight, often do so because they are concerned about looking too big. Their increased size is attributed to an increased volume of fat. When people try to ...
23
votes
3answers
33k views

If the brain has no pain receptors, how come you can get a headache?

I've read many years ago in books, that the brain has no nerves on it, and if someone was touching your brain, you couldn't feel a thing. Just two days before now, I had a very bad migraine, due to a ...
4
votes
2answers
77 views

How are there multiple varieties of the potato?

The potato appears to propagate by growing an 'eye'/'bud' which eventually grows into a new plant. So there would probably be single representative of the potato species in the world with all others ...
11
votes
1answer
176 views

Does sleep in humans re-structure based on the expected sleep time?

I've read about anecdotal evidence that human brain has a fairly good internal clock that can be used to judge the amount of time that has passed. I'm wandering if there are any mechanisms in the ...
2
votes
1answer
147 views

How stable is in vivo whole cell patch clamping?

For a head fixed animal, how stable is the current state-of-the-art whole cell recording from a cortical neuron? The animal's breathing, and heart beat must move the neuron relative to the recording ...
6
votes
3answers
2k views

Why do grapes not shrink when placed in strong sugar solution?

I tried an experiment. First, I placed grapes in pure water(hypotonic solution). The grapes burst because of endosmosis. Then, I placed new set of grapes in strong sugar solution(fully saturated) but ...
3
votes
2answers
275 views

Do Yeast Insertion constructs revert?

If I insert a new gene with a yeast integrating plasmid and select with a drop out culture once, can I assume that the newly integrated gene will stay in the strain without putting selective pressure ...
2
votes
2answers
395 views

How are different types of cells created from zygote?

In the process of mitosis that starts from zygote, how do different cells appear? What happens that some cells become one type and some another? For example, is there a cell that divides into a ...
1
vote
1answer
59 views

Arabidopsis thaliana RCSB active site gene mutant

I'm looking for an Arabidopsis thaliana gene listed in RCSB with a clear mode of function and active site. In addition it needs to have an obvious phenotype when knocked out like severely retarded ...
1
vote
3answers
95 views

Are all healthy animals more likely to defecate near the end of a rest-cycle?

Just what the title states. It stems from observation & personal experience that a person/dog/cat/monkey is more likely to relieve oneself immediately after it wakes up from the peak-sleep cycle ...
25
votes
5answers
625 views

Are there any substance that are more dangerous at low dose than at higher dose?

It is commonly admitted that The dose makes the poison which means as a person, the more I take a substance, the more risk I take for my health. There is even an indicator called LD50 (see ...
10
votes
2answers
225 views

Is there life on other planets and if so how frequent?

Some shed tears of joy as the news about the successful landing of the Mars Rover Curiosity came in. Then the most comprehensive 3D map of our observable universe was published. 2012 is literally an ...
6
votes
1answer
561 views

What causes the characteristic 'gleam' in the eye of a living being?

The title is pretty much what I seek to know. Unless the other person is play-acting, one can often make out the eye of a living person has a shine-of-life to it; a cadaver does not. Similarly the ...
7
votes
2answers
1k views

How are babies born without a brain?

In the United States, anencephaly occurs in about 1 out of every 10,000 births. There are several forms of this condition, wherein the forebrain is absent. The forebrain is host to most of the higher ...
3
votes
1answer
546 views

Are there any multi-cellular organisms out there that do not sleep?

Looking around I see animals - ants, bees, birds, lizards, roaches all the way up to humans appear during a part of the day and not other parts. I would guess there is a sleep/recovery cycle involved. ...
6
votes
2answers
7k views

Does mixing alcoholic drinks really make you more drunk?

There is plenty of anecdotal evidence ("beer after wine and you'll feel fine, wine after beer will make you feel queer") that mixing alcoholic drink types leads to a stronger effect, but I can't find ...
12
votes
2answers
2k views

Why do neurons have only one axon?

I have just learnt about neurons. I wonder why neurons have only one axon. Can they transmit nerve impulses faster and more rapidly when they have more axons? Does having more axons help in ...
5
votes
1answer
298 views

Why do carrots spoil so fast?

The carrots we buy from a supermarkets spoil very fast, albeit giving many consumers a false sense of preservability due to their structural rigidity. The answer extends to many other vegetables many ...
6
votes
2answers
2k views

Why are antibiotics prescribed with a viral infection like a cold?

I've heard both ways; people going to the doctor for a cold and then getting a prescription for antibiotics and those that go to the doctor and told they have ride it out because it's a viral ...
4
votes
2answers
80 views

What are some of the immediate challenges to break through before finding a cure for mad cow disease?

What are the immediate challenges to break through in seeking a cure for mad cow disease? I know that mad cow disease has no treatment as of yet.
11
votes
1answer
364 views

How can an albatross stay airborne for months?

Albatrosses, of the biological family Diomedeidae, are large seabirds allied to the procellariids, storm-petrels and diving-petrels in the order Procellariiformes. They range widely in the Southern ...
8
votes
2answers
3k views

Use of amino-acid sequences versus use of nucleotide sequences in phylogenetic analysis

Reading a paper about gene evolution, I see that they do phylogenetic analysis for bacteria using protein sequences. They take the method from another paper. I can suspect that amino-acid sequences ...
12
votes
1answer
334 views

Can DNA act as a translation substrate?

I get conflicting answers. One would think if it was true, it would be rather seminal and widely known. There are papers from Khorana[1], Holland[2], and Bretscher[3] (late 60s) that suggest that it ...
1
vote
3answers
336 views

Do Viruses produce a biomagnetic field?

From wikipedia: Biomagnetism is the phenomenon of magnetic fields produced by living organisms. The present scientific definition took form in the 1970s, when an increasing number of researchers ...
8
votes
2answers
25k views

What is the difference between an antibiotic and an antibacterial?

Concerning medicine, what are the differences between antibiotics and antibacterials?

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