3
votes
0answers
26 views

Is it possible to isolate and analyse intermediates of protein folding?

I would like to know if there is an assay which could allow us to analyse a protein before it has assumed its 3D functional form. While studying structural biology, I only came to know the forces that ...
3
votes
0answers
58 views

How to explain Genome, Genes, RNA and protein in one figure to non-biologist?

I have a presentation to do where non-biologist are attending. In order to introduce a little bit my work I have to do a quick summary on genomes. So what is a genome, a gene, an mRNA and a protein. ...
3
votes
0answers
55 views

Degree of dosage compensation in Drosophila melanogaster

In this paper the authors state that the dosage compensation seen in Drosophila is approximately twofold, but they do not provide any source or numbers (as far as I can see) for this. What is the mean ...
3
votes
0answers
60 views

How we share pain?

When somebody else tells me about his or her itching or pain in some specific body part I sometimes begin to feel similar feelings. I can think of about three explanations: I feel pain all over my ...
3
votes
0answers
27 views

Protein-Bound Drugs in Kwashiorkor

Kwashiorkor is characterised by decreased serum protein (including serum albumin) due to poor dietary protein intake. What is the effect of this lowered serum protein on highly-protein-bound drugs? ...
3
votes
0answers
21 views

How to differentiate between similar looking carps efficiently?

Carps look almost the same (e.g - Rohu, Catla). So, is there a specific distinguishing set of characteristics to help determine their species just by looking at them from afar (or maybe in some other ...
3
votes
0answers
42 views

Normal ECG/EKG Measurement?

I'm getting started using ECG using a 3 lead system by iWorx. I have place the leads on my two wrists and the ground on my ankle and have recorded some data into the provided LabScribe 3 software ...
3
votes
0answers
46 views

Human leukocytes (re)circulation/migration in homeostatic state

One can easily find information on the topic of leukocytes trafficking between vessels and peripheral tissues during inflammation. But what happens during normal states when there is no pathology? ...
3
votes
0answers
98 views

How close to Earth's core can organisms live?

We don't to know much about organisms living deep below the Earth's crust. Recently a team led by S. Giovanni discovered some microbes 300 m below the ocean floor. The microbes were found to be a ...
3
votes
0answers
40 views

Can we artificially increase human growth using HGH?

Robert Pershing Wadlow was a man who lived in the early-mid 1900s and had hyperplasia of his pituitary gland, which caused him over-produce human growth hormone (HGH) and grow to nearly 9 feet ...
3
votes
0answers
47 views

Why aren't circadian rhythms exactly 24 hours long?

Most organisms exhibit circadian rhythms that have a periodicity of about, but not exactly 24 hours. Why is this? And to what extent can variation in periodicity in circadian rhythms among the ...
3
votes
0answers
34 views

How does beta branching stop alpha helices from forming?

I am told that beta branching interferes with alpha helix formation. Problem is that I don't see how beta branching has anything to do with alpha-helix formation. Beta-branches are on the outside of ...
3
votes
0answers
79 views

Up to date, extensive documentary about dinosaurs?

I just finished reading the Wikipedia page about dinosaurs, and I very much enjoyed it. I knew that much of what I learned in the 80's as a child is (and was) incorrect, and now that I am a parent, I ...
3
votes
0answers
47 views

eradicating h.pylori naturally

This question is not to discuss whether substances with anti-h.pylori agents works or not, or the pros and cons of such but from a medical perspective. Assuming that one manage to control, reduce, or ...
3
votes
0answers
70 views

Largest direct ancestor of humans

Going back the genealogical lineage from present humans to the beginning of life, what was the biggest - in terms of body size or mass - animal in this sequence? More generally, what would a time vs. ...
3
votes
0answers
31 views

What are the biological mechanisms of candy causing nausea?

As I sit here after eating too much chocolate, I wonder: What are the biological mechanisms behind eating too much candy candy causing nausea in a healthy individual? Is it a spike in blood sugar, ...
3
votes
0answers
104 views

How to prevent e coli from clumping (for FACS)?

I'm performing FACS on e coli, but the cells are clumping together so each event is multiple cells. I ran a control where I had one flask of e coli expressing GFP, and one flask expressing RFP. Run ...
3
votes
0answers
30 views

Color perception vs shade perception demo

I can't seem to find one of the best demos I've seen of color vs brightness perception. It consisted of a rotating animation of earth made of red of bright red points on a dark green background. As ...
3
votes
0answers
95 views

How did birds survive the KT impact?

As I understand it, the ejecta resulting from the K-T impact (also known as the end-Cretaceous or Cretaceous-Tertiary extinction event) re-entered the atmosphere all over the world; the heat from ...
3
votes
0answers
29 views

More extreme phenotypes when parents are from diverged populations

In quantitative traits we have many loci affecting a trait. If we took a bunch of parents where all mothers and fathers were of a certain value at the upper end of a trait range, and then looked at ...
3
votes
0answers
45 views

Niche differentiation in birds of prey

I'm not much of an ornithologist but I know enough to distinguish most Central European birds of prey. To me it is amazing that there are so many species that seem to occupy the same niche. Especially ...
3
votes
0answers
66 views

Which organs in the body are responsible for measuring temperature?

As an instrumentation engineer, I have designed temperature control systems capable of measuring and controlling temperature with a precision of 0.001K over a wide temperature range. I have always ...
3
votes
0answers
41 views

How many cells are there in the apical meristematic tissue?

How many cells are there in the apical meristematic tissue? Looking at this picture... , I would tend to think that there are few hundreds cells in the meristem tissue. But I guess this is a ...
3
votes
0answers
27 views

Gibson assembly - primer design with A and T rich regions

I have question about Gibson assembly. I have done it several times and it always worked okay for us, but now I want to assemble together a fragment which has sequence like this: ...
3
votes
0answers
80 views

Understanding the meaning of $s$ and $t$ in a population genetics equation

Sewall Wright in this article (1937) at the end of page 313 gives the equation: $$\Delta q = (s+tq)q(1-q) \space\space\space\space\space\space\space\space\space(1)$$ This equation is an ...
3
votes
0answers
250 views

Questions about insects eating flour and living in the cracks of a wooden cutting boards

I have a large wooden cutting board which is used in kitchen mainly for preparing egg pasta. The wood type is Populus (poplar or aspen or cottonwood). The main ingredients used with the cutting board ...
3
votes
0answers
114 views

Which types of blood vessels can regenerate in humans/mammals?

Which types of blood vessels can regenerate in humans/mammals? From what I understand, arteries and arterioles can be created later in life, while this is not necessarily the case with veins. However ...
3
votes
0answers
84 views

At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...
3
votes
0answers
18 views

Evolutionary motivation behind number of neurons in DCMMP

I'm studying neuro-anatomy right now and I was surprised to learn that there are only three neurons along the Dorsal Column Medial Lemniscal Pathway (DMLP) which relays mechanical sensations from the ...
3
votes
0answers
58 views

Does this “fleeing spiders leaving fields of webs” phenomenon have a name?

I have recently seen images of big areas covered in spider webs: After flood in Australia http://www.viralnova.com/spider-fields/ ...
3
votes
0answers
52 views

TV's so loud when I turn over

Scenario: I'm about to fall asleep with the T.V. on. Having completely forgotten that it was, no longer even hearing it, just before falling asleep I turn over with a 'fresh' ear and it's blaring. If ...
3
votes
0answers
161 views

Hoechst red and blue spectra - what does the red emission tell us?

I understand that the blue spectrum is emitted when Hoechst 33342 binds to nuclear DNA. But what exactly is the red spectrum telling us? I read that the red spectrum can be indicative of apoptosis, ...
3
votes
0answers
33 views

Do I need to use the same WT C57BL individual for back-crossing or can I use a new one for each generation?

I've just received heterozygote C57BL mice from COMP and I need to start back-crossing them. I've read many colony management protocols, but couldn't understand if I need to use the same WT mouse for ...
3
votes
0answers
62 views

Relationship between mN and mg in vessel contraction studies?

What is the relationship between mN and mg as the units involved to measure the changes in contraction? A tool most widely used is an instrument called myograph. In these exoeriments, either units of ...
3
votes
0answers
53 views

Viagra for pain management

Not all men who take Viagra experience any sexual side effects about 40% have no change of sexual abilities on the pill. However like many women the drug in such cases cause a strong pain reduction ...
3
votes
0answers
62 views

Why are watermelons sweeter in the center?

Today I had a slice of watermelon and when I reached the outer parts of the pulp I wondered why those are less sweet. Whether or not the sugar occurs in crystalline form in watermelons is still an ...
3
votes
0answers
40 views

DNA barcoding, querry regarding tree based (cluster) methods for species identification

I am working on success rate of DNA barcoding in identification of species using distance and tree based methods. Regarding distance based method, I have used Adhoc and species identifier and ...
3
votes
0answers
70 views

Total number of pleura in the exoskeleton of cockroach

Basically as far as i know cockroach consists of 10 terga and 9 sterna but what are the total number of pleura present in the cockroach. Pleura are situated between tergum and sternum of a body ...
3
votes
0answers
147 views

Accuracy of genome size estimation by flow cytometry

I'm working on a genome project and using an in silico k-mer analysis to estimate the size of our genome based on the available Illumina reads. The k-mer based estimate is consistent across a wide ...
3
votes
0answers
47 views

How can cells produce antibodies despite error-checking mechanisms in their genomes?

How can immune cells produce so many different kinds of antibodies with different variable regions if there are so many mechanisms inside the cells that try to keep the DNA sequence as constant as ...
3
votes
0answers
56 views

Are small CO₂ concentrations devastating to certain cognitive tasks?

A new study shows strong effects of what should be a negligible CO2 concentration. The paper "Is CO2 an Indoor Pollutant? Direct Effects of Low-to-Moderate CO2 Concentrations on Human Decision-Making ...
3
votes
0answers
125 views

Human female chest model or data representation?

I am looking for professionally used representation of female chest (I know how it sounds ;). Generally - a model comprehensive enough to effectively represent human chest, with focus on breasts. ...
3
votes
0answers
51 views

Inbreeding Coefficient and Coefficient of Relationship

Wikipedia gives the following formula to calculate a "path of coefficient of relationship" between an ancestor $A$ and an offspring $O$: $$\rho_{AO} = 2^{-n} \left( \frac{1+f_A}{1+f_O} \right)^{1/2} ...
3
votes
0answers
84 views

What is the main challenge in creating a chemical male contraceptive?

More than 50 years after hormonal contraception for women was invented, a contraceptive pill for males is still not available. With the obvious major biological differences in mind, why does it appear ...
3
votes
0answers
80 views

A day in Beijing is like smoking Only one sixth of a cigarette

This is the title of this blog post followed by this other good post. I'm particularly anti-tobacco-smoke, at the point of not always considering other pollution, and this article shows how this kind ...
3
votes
0answers
155 views

Gibson assembly using NeBuilder

I am supposed to construct a plasmid that contains features from two other plasmids. My strategy is to generate three fragments form the two other plasmids. I was encouraged to try Gibson assembly, ...
3
votes
0answers
272 views

Do Asian women have more difficult births than Europeans?

I recently heard a claim that Asians in general have more difficult births than Europeans. Is this true? I have found a few studies(1,2) on the effect of ethnicity on birth outcomes but they seem to ...
3
votes
0answers
86 views

Why don't surfactants destroy or incorporate into cell membranes?

How do surfactants remain on the surface of pneumocytes without (1) acting as a detergent or (2) the phospholipids getting incorporated into the membranes of pneumocytes... I'm guessing the answer ...
3
votes
0answers
84 views

Could miniaturization be used to protect endangered large species?

In some animals (like dogs) size seems like it's controlled mostly by just a few genes (IGF1, and the genes that repress it). I'm curious: (1) Does other miniaturization takes a similar route (for ...
3
votes
0answers
72 views

What metabolic processes do dormant and ungerminated seeds carry out?

What metabolic processes does a dormant embryo in a seed carry out? Seeds will not germinate, either because of a lack of favourable conditions, seed hibernation, or because of a genetically ...

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