0
votes
0answers
38 views

Can defibrillation (cardiac arrest treatment) be done with a vehicle spark plug? [on hold]

Can successful defibrillation (restarting the heart after cardiac arrest) be done with a spark plug from a vehicle (possibly offroad vehicle)? Is it POSSIBLE for this to work? Let's say you are stuck ...
5
votes
2answers
54 views

Insect making continuous sound in summers

In deciduous to tropical-deciduous forests and residential places with such vegetation I have found this insect to make continuous sounds all through the day (even in nights sometimes) during the ...
0
votes
0answers
14 views

What are extracellular matrix pathways?

I was reading a research paper dealing with acute myeloid leukemia and the term "extracellular matrix pathway" came up. What does it mean? I found literature on extracellular matrix, but I'm not sure ...
0
votes
1answer
24 views

Are antibiotic-resistant bacteria necessarily less virulent than their original strain?

In the absence of antibiotic treatment, is there a reduction in the average severity of disease caused by resistant strains of pathogenic bacteria compared to wild-type ones? I would assume that ...
1
vote
1answer
20 views

How to calculate apparent diffusion coefficient (ADC) with example?

Can someone give an example calculation for the apparent diffusion coefficient (ADC)? There appears to be multiple ways that this can be calculated, e.g. as discussed here: http://www.ncbi.nlm.nih....
-2
votes
1answer
66 views

What was the precursor of testosterone? [closed]

Testosterone evolved about 500 million years ago (says 8fact.com). What was the precursor of testosterone (if any)? If possible, what caused the 'precursor' to evolve?
-1
votes
1answer
41 views

How does imatinib recognize the constitutively active Abl-BCR even though it binds to the inactive conformation?

In chronic myelogenous leukemia (CML) ABL-BCR is constitutively active (always on) and it can be inhibited by imatinib and dasatinib. A study says that imatinib binds to the inactivated state of the (...
-1
votes
1answer
23 views

How are unnatural amino acids modelled using insilico tools?

When the structure of an unknown protein containing amino acids other than the 20 known natural amino acids is modelled which method is primarily used in bioinformatics to solve the structure? what is ...
0
votes
2answers
29 views

Energy coupling between two spontaneous reactions?

This diagram describes energy coupling between a nonspontaneous reaction (the formation of glutamine from glutamic acid and ammonia) and a spontaneous reaction (the hydrolysis of ATP). I can see that ...
0
votes
0answers
12 views

optimization of density gradient centrifugation

I'm trying to isolate a ~320kD protein (in oligomeric form) using density gradient ultra centrifugation technique. Can any one tell me that what gradient (sucrose or glycerol or trehalose or etc) I ...
1
vote
1answer
64 views

How do heredity and regression to the mean work with respect to intelligence?

I am trying to understand the heredity of intelligence between generations in general, and how regression to the mean works in detail in particular. The answer I'm looking for should preferably answer ...
1
vote
2answers
52 views

What´s the origin of junk DNA?

Most eukaryotes posses a certain amount of junk DNA in their cell nuclei. What is (are) the origin(s) of this junk DNA, And is it realy junk (superfluous)?
0
votes
0answers
29 views

How do I know if the tRNA gene is under purifying selection from looking at a sequence dataset?

I'm having trouble figuring out how to tell if a tRNA gene is under purifying selection, just by looking at its sequence dataset. Such as this one:
0
votes
0answers
17 views

How to Determine Sufficient Time for Melanoma Survivor to Be Considered Low Risk?

Regarding melanoma, how do we determine the minimum amount of time that a patient is disease free for them to be considered low risk? We are attempting to do survival analysis on RNASeq data from ...
1
vote
1answer
12 views

How do molecules signal pre synaptic neurons to activate? [closed]

How do molecules signal pre synaptic neurons to activate? and also is it more the structure or the elements in the molecule that allows it to activate the neuron also how do molecules bind to ...
0
votes
0answers
13 views

Why is your taste affected due to sinuses?

I heard someone say "My sinuses are acting up, I cant taste the food." I dont think the person is lying, they probably believe this but I'm having trouble seeing how the sinuses would affect the taste ...
4
votes
1answer
33 views

Need Help Identifying this Critter (Insect?)

This creature is hanging out on my kitchen window. I live in Western Maryland, US, near the Potomac River. The creature is about 3 inches long (measured from tip of mandibles to tip of tail). Does ...
1
vote
0answers
16 views

Is Valerian diuretic or antidiuretic

Hello i wanted to take valerian to calm me down on stress situations, and also using it as an antidiuretic, but i have seen forums where people say it acts as an diuretic, and others where they said ...
0
votes
0answers
14 views

What is the difference between desert and migratory locust?

I know both are species of short horned grasshoppers and belongs to the orthoptera order, Acrididae family and so on. But what is the difference between desert and migratory locust? How do we ...
0
votes
1answer
31 views

What is the meaning of a reported OD600 value?

I can't find a reference that explains what, for example, OD600 = 0.1 means. For example, Wikipedia states OD600 is an abbreviation indicating the absorbance, or optical density, of a sample ...
0
votes
2answers
44 views

DNA replication in E.coli

What is the difference between replication and to divide? My A level bio book says that it takes 20 min for E.coli to divide and in next page it's written that E.coli completes replication within ...
3
votes
3answers
147 views

How is the size of a gene defined?

Is there an agreed definition as to how many nucleic acid bases constitute a gene? If not, why not? I'm not sure I understand how the exact sizes of genes are defined.
-2
votes
1answer
66 views

how did the domestic dog evolve and was the role humans played in its evolution justified? [closed]

Humans have been selectively breeding dogs for a long time. Why do we do it? What are the positive and negative impacts of selective breeding and why do they occur? I am writing an independent ...
3
votes
0answers
57 views

In vivo delivery of ssDNA

I am looking for a system with which I can deliver (large quantities of) ssDNA in vivo (say in mice). I do not know whether it is of importance but the 5' end of the ssDNA fragments are assumed to be ...
-1
votes
0answers
28 views

Where does transamination and deamination take place?

The only information I know is about deamination,it occurs in the liver and kidney. But in which part of the cell does deamination occur? To which tissues is transsamination specific to and in which ...
3
votes
1answer
36 views

Why does migration distance depend on log of molecular weight in SDS-PAGE?

I really want to know why in the result of SDS PAGE, log of molecular weight(MW) and migration distance (distance from the loading well) have a linear relationship. Why is it log(MW) instead of MW? ...
0
votes
1answer
40 views

A diagram of a crossover [closed]

How can one draw a crossover between ABK and aBk where genes A and B follow the Mendel's law of independent assortment and gene K does not i.e. K is linked to B?
-1
votes
2answers
36 views

Is there software or a website where I can browse extinct species?

Is there any software/website where I can browse for extinct species? It must be based on real animals that are now extinct. It may be in animated versions.
-2
votes
1answer
44 views

Would someone lose some of their traits if they stop using them for some time? [closed]

A co-worker of mine told me, that there are some mutations in the genome during the life of a human body. So, the body changes genes to fit better into the surrounding environment. My thought is now, ...
0
votes
0answers
28 views

What empirical evidence of genetic assimilation is there?

There have been many articles arguing that we should view the phenotype in the center of evolutionary theory rather than the genotype as done in most population (or quantitative) genetics. A typical ...
3
votes
1answer
29 views

Is this modification of Livak's 2-delta delta CT method valid?

I have done a modification to include qPCR efficiency in the calculations: In a given gene I calculate the fold changes relative to an arbitrary sample. That sample will be one and the rest will ...
3
votes
1answer
51 views

Perplexing by the way of estimating the shared or different genes between humans and chimps

We share 98.5% genes with chimps (it means we have 98.5% same DNA sequeces ),so there is about one percent difference .It means we can approximately differ from them by one base pair every hundred ...
1
vote
0answers
16 views

Are there any individual animals that can thrive in a wide range of core temperatures? [closed]

Surely, some cold blooded animals are in a position where they can't escape the changing temperatures the environment throws at them, so natural selection would have enabled them to thrive in a wide ...
5
votes
1answer
36 views

How allele is related to trait that is more complex than two cases (ex. height)?

Recently I started to learn about evolution and genetics. Simple stuff at the beginning - some videos, some reading. So far, everything seems to be pretty simple and straightforward. I easily grasp ...
1
vote
2answers
65 views

Relationship between DNA strands and mRNA

Does the sense strand or antisense strand of DNA code for the polypeptide product? I'm confused because I know the antisense strand is the template for mRNA but it has anti codons so I do not know how ...
1
vote
0answers
10 views

Has research indicated how much koinophillia preferences are learned vs insinctual

I'm curious about rather the definition of 'normal', as it affects koinophillia & mate choice, is something instinctual or learned. To clarify I'm not asking if koinophillia itself is ...
1
vote
1answer
18 views

Binding kinetics of 6xHis-Tag

For the planning of an experiment I would like to know the binding kinetics (kon and koff) of a 6x-His-tag to a Ni-NTA surface. I know they should differ due to surface quality and position of the ...
12
votes
1answer
101 views

What made this black cluster on a leaf?

I found this black slug-shaped thing on a leaf by my pond in western Sweden. It's about 15 mm long, positioned on a vertical leaf (I bent it to take the picture). And I don't even know where to ...
-1
votes
0answers
32 views

If drinking nothing but distilled water kills you what happens when you're injected with it?

I've read that drinking distilled water and eating nothing can kill you, and I was wondering what would happen if someone injected it into your bloodstream?
0
votes
0answers
18 views

Can we make an artificial chromosome?

I know things like BAC and YAC exist. I am thinking of a chromosome the size of those we find in mammals. Say 60 million nucleotides. How big can we make a chromosome with modern technologies without ...
-2
votes
1answer
84 views

Insect species identification [closed]

I think it's a moth and need further identification like scientific name, order and family. The picture was taken on May 30/2016 in my university laboratory window in South Korea. At that time there ...
0
votes
0answers
12 views

How does entanglement explain myoglobin's preference for $O_2$? [migrated]

I was reading an article about the myoglobin's unusual preference for $O_2$ than CO, in which I found: It turns out that some electrons in the myoglobin involved in binding CO and O2 exhibit a ...
1
vote
0answers
20 views

What is meant by clinical progression? [closed]

What do the terms 'clinical progression' and 'disease progression' mean? Are they different from each other?
3
votes
0answers
31 views

Why does crippling pain exist? [closed]

Some kinds of trauma can cause pain so severe that it makes you unable to move or do anything at all. It may put you out of action and unable to help yourself because of how excruciating it is. ...
1
vote
2answers
61 views

Can a small polypeptide fold over itself and have a tertiary structure?

What I want to know is if polypeptides (those which are not considered as proteins) can also "exhibit" a tertiary structure.
2
votes
0answers
23 views

Can the respiratory quotient be calculated from a formula or must it be measured directly?

I found the following question on the Respiratory quotient: A normal human diet has a Respiratory quotient (RQ) of approximately 0.85. Given that pure oxidation of fatty acids has a Respiratory ...
3
votes
0answers
25 views

What is the effective population size of a simple two deme metapopulation?

I am confused as to how to compute the effective population size $N_e$ of a theoretical structured population. Let's consider here a simple case study. Imagine a 2-deme metapopulation. Each deme is ...
3
votes
2answers
48 views

Age-Dependent STD Infection

It seems that young females (comparing age 15 vs age 24) are 20x more likely to get chlamydia from a single unprotected sexual encounter with an infected male. What are the reasons for this? Are ...
0
votes
0answers
17 views

Do Tumor-Infiltrating T Cells Experience Any Prolonged Effects Due To Hypoxia After They Return To Normoxia?

Adoptive cell transfer (ACT) therapy using tumor-inflitrating lymphocytes (TIL) is at the cutting edge of immuno-oncology treatments involving metastatic melanoma and other indications (1). The idea ...
3
votes
0answers
20 views

Phase Transitions of Purified Proteins

Why do solutions of purified protein condense into droplet phases? I'm trying to understand the protein phase transitions. Here is the article http://www.cell.com/cell/fulltext/S0092-8674(12)00634-4#...

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