14
votes
1answer
131 views

Are there animal models for Clostridium difficile that better replicate human infection than hamsters?

So I'm looking for some information on the infectious dose necessary to colonize a human with Clostridium difficile. There's no human challenge studies, and since it's not a foodborne pathogen, little ...
14
votes
1answer
156 views

Has the human 7-day week had any impact on the evolution of species?

Most (if not all) industrialized countries follow a 7-day work week now, such that we are bound to follow a certain weekly trend in matters such as pollution generation, where to go (e.g. stay in town ...
14
votes
1answer
296 views

Fibonacci sequence in nature, truth or just wishful thinking?

I'm reading a bit on the Fibonacci sequence in nature, be it the golden ratio or the golden spiral forming over and over again in biological structures, and then I came across this online article by ...
13
votes
3answers
2k views

What causes the development of antibiotic-resistant strains of bacteria?

I understand bacteria have become resistant to antibiotics due to selection pressures, but how do resistant bacteria process antibiotics when exposed to it, compared to non-resistant bacteria. Also, ...
13
votes
5answers
319 views

Can species back-evolve?

One of the tenets of Darwin's theory is the survival of the fittest, ie adaptation of features that allow a species to adapt better to its surrounding environment. I am wondering that given the right ...
13
votes
4answers
948 views

Are there any examples of sudden leaps in evolution?

As far as I understand, various abilities like flying, sight, hearing etc. were caused by slow evolution, where those with a greater ability to to these things had better chance of survival. (If this ...
13
votes
4answers
40k views

Why is DNA replication performed in the 5' to 3' direction?

DNA replication goes in the 5' to 3' direction because DNA polymerase acts on the 3'-OH of the existing strand for adding free nucleotides. Is there any biochemical reason why all organisms evolved to ...
13
votes
3answers
2k views

How does the human body metabolize gasoline?

A Chinese man has been drinking gasoline to relieve his pain for 25 years. How does the human body metabolize gasoline? Also, what are the side-affects to gasoline?
13
votes
3answers
658 views

How many human proteins have a solved 3D structure?

I was wondering how many human proteins have a solved 3D structure. Is there a database with only human proteins? I looked at pdb but couldn't find a filter.
13
votes
3answers
2k views

When has an organism evolved enough to be called a new species?

Imagine that we take a population of horses, split them in half and place them in completely different environments. The two species will evolve separate from each other and because the environment is ...
13
votes
2answers
3k views

How will rising carbon dioxide levels in the troposphere affect photosynthetic producers?

Much discussion has been had about the affects of climate change on plantlife, but how will rising carbon dioxide concentrations affect the photosynthetic process itself? Since CO2 is a reagent in ...
13
votes
2answers
345 views

Evolution in 37 years, is it possible?

I am confused, can evolution ( speciation ) really occur in such a short time ? In 1971, biologists moved five adult pairs of Italian wall lizards from their home island of Pod Kopiste, in the ...
13
votes
2answers
456 views

Intrinsically disordered proteins as potential drug targets

Intrinsically disordered proteins (IDPs) are a class of proteins that do not adopt a stable secondary or tertiary structure under physiological conditions in vitro, but still have biological ...
13
votes
3answers
988 views

What implications has the missing 2'-OH on the capability of DNA to form 3D structures?

The chemical difference between RNA and DNA is the missing 2'-hydroxyl group in the nucleotides that build DNA. The major effect of that change that I know of is the higher stability of DNA compared ...
13
votes
4answers
960 views

Could we transmit smells electronically?

We can encode sound and images in radio waves and send them, but presumably there's some physiological reason that we can't easily make a picture or video of a smell. Could we realistically break ...
13
votes
2answers
574 views

Does testosterone increase female sexual behavior?

According to my lecture notes testosterone generally increases sexual behavior. Given that it's generally thought to be the male hormone I'm not quite sure whether they mean that it also increases ...
13
votes
2answers
608 views

How Do Galls Form?

I am curious how Gall Wasps, bacteria and other organisms induce galls to form. Specifically, what chemicals induce gall formation?
13
votes
2answers
4k views

Why do people have antibodies against other blood types?

The ABO blood type divides each blood type according to whether they have the "A" and "B" antigen(s) (AB has both, O has none). People also have antibodies against the antigens they don't have (AB has ...
13
votes
2answers
2k views

What effect does vortexing have on a fluid sample that simple mechanical shaking does not?

Some protocols call for fluid samples to be mixed with a "vortexer" on the high setting. What effect does the vortexing have on fluid samples that mechanical shaking does not? Does it shear long ...
13
votes
2answers
244 views

Percentage of genome devoted to regulating gene expression

Recently I've been studying the p53 tumor suppressor gene as a model for regulation of gene expression. It's amazing how many different post-translational modifications are known to regulate p53 ...
13
votes
1answer
2k views

How does a plant grow before photosynthesis is possible?

During photosynthesis, a plant translates CO2, water and light into O2. I assume the carbon C is further used for the growing process. I wonder how the plant grows before the time where photosynthesis ...
13
votes
2answers
762 views

Is the EC50 of an activating protein for an enzyme a good indicator for the binding affinity Kd?

We work with a membrane protein system where measuring the affinity between the enzyme and the upstream activating protein has been difficult, and when measured in detergent solution, it is almost 100 ...
13
votes
2answers
144 views

Relationship between our microbiome and personalized nutrition

Recently, it has been asked whether there are 'metabolic types' between humans that can benefit from a sort of personalized nutrition. One answer suggested that one discerning factor could be the ...
13
votes
4answers
2k views

Why is the Hydra Biologically Immortal?

I have heard that the Hydra organism is biologically immortal (later I found that there are more immortal organisms). Now I know that its immortality is related to its telomerase. The thing is that we ...
13
votes
2answers
12k views

Possible? When a pregnant woman suffers an organ damage, fetus would send stem cells to the damage organ to help repair it?

I am quite sure that there is this blood-placental barrier between the mother and the baby so that nothing (except a type of antibody) can pass through it. But I remember reading somewhere that when ...
13
votes
3answers
236 views

Can plants get cancer?

I can't think of any reason why plants wouldn't be able to get cancer, but I've never heard of a plant growing a tumor. I've also never seen a plant with a noticeable abnormal growth. Can plants get ...
13
votes
2answers
2k views

How many people are required to maintain genetic diversity?

Imagine humans were to colonize a distant planet and it was a single one-way trip. How many people would they need to bring? Obviously 2 is the minimum, but that would result in a lot of inbreeding. ...
13
votes
1answer
715 views

Are human bodies programmed to die?

Following from this question: What is the evolutionary advantage of death?: Is there any evidence that human bodies have systemic self-destruction built into their developmental program? I'm not ...
13
votes
1answer
7k views

What effect has changing pH and salt concentration on protein complexes?

I'm struggling to find peer reviewed literature that explains the effect of changing the pH and the salt concentration on protein/protein complexes in solution. What effect does the pH and the salt ...
13
votes
1answer
416 views

How do porcupines keep from pricking each other while mating?

How do porcupines keep from pricking each other while mating? It seems like they would constantly be scratching each other.
13
votes
2answers
266 views

When does BLAST fail to align 2 DNA sequences?

This is an assignment that had confused me for a long time. So I think you guys who study computational biology might be interested. The original question is: Find the two most similar DNA ...
13
votes
1answer
191 views

How does herpes (HSV) infection suppress HIV?

HIV compromises the human body to defend against infection. Yet people who are infected with herpes are at less risk of developing AIDS. How does this work?
13
votes
2answers
203 views

What is the contribution of viruses to the evolution of mankind?

I'm interested in horizontal gene transfer in bacteria, viruses, and organisms such as Bdelloid Rotifers. I've just read in Carl Zimmer's 'A Planet of Viruses' the following passage: As a host ...
13
votes
1answer
189 views

What is the prehistory of amino acids in cells?

As a followup to Why 20 amino acids instead of 64? and What is the smallest number of amino acids required for life?, I am trying to understand the prehistory of amino acids in cells. All living ...
13
votes
2answers
2k views

How many organisms have ever lived on Earth?

I've looked for some information on this, but couldn't find anything useful. Has there been any noteworthy attempt to estimate the sum amount of individuals of all species that have ever lived on ...
13
votes
1answer
2k views

Why do we grow so much hair on our heads compared to our bodies?

I've been wondering about head hair, facial hair in particular. Human males can grow very extensive beards should they choose to not shave - however you do not really see this in our chimpanzee ...
13
votes
1answer
438 views

How fast will cells lyse under hypotonic conditions?

Routinely, lysis of cells with hypotonic solutions is carried out along with some physical (douncing) or enzymatic (lysozyme) method to break open the cells. If one were not to do any of these and ...
13
votes
5answers
5k views

Origin, or source, of rhesus negative in human blood

This is my first post here, so please be gentle. I recently learned that I have Rh- blood (I'm A-), and was idly looking into blood types on Wikipedia. I was surprised to find that relatively few ...
13
votes
2answers
228 views

Can parts of a human brain be asleep independently of each other, or vary in the times required for them to fall asleep?

I know that some birds and marine animals can continue complicated activity (swimming, flying?) while one hemisphere of their brain is asleep. I'm interested if human brain has some parts of it that ...
13
votes
1answer
179 views

How straightforward is in vitro compartmentalization?

in vitro compartmentalization (IVC) is one of those technologies that everyone knows about, talks about, but never actual does due to the rather technical difficulties in setting the system up. I was ...
13
votes
1answer
231 views

Do the majority of fish lack scales on their heads?

Based on pictures, it seems to me that a vast majority of fish species that have scales do NOT have scales on their heads. Is that fact true? To make this properly answerable: lets' define a ...
13
votes
0answers
112 views

Haidinger's brush: Is this a by-product of the eye's physics, or are there any evolutionary grounds for it?

The human eye is, very subtly, sensitive to the polarization of light. This is an effect known as Haidinger's brush (see Wikipedia article of this name). What, if anything, is known or at least ...
12
votes
9answers
7k views

Why have humans evolved much more quickly than other animals?

Humans have, in a relatively short amount of time, evolved from apes on the African plains to upright brainiacs with nukes, computers, and space travel. Meanwhile, a lion is still a lion and a ...
12
votes
10answers
820 views

A good book for history of biology/biotechnology for lay people

I have many friends who are interested in Biology and want to know more about the subject in general (like a history of biology, from Darwin's theory, to DNA structure discovery, to the human genome ...
12
votes
5answers
317 views

Is it the case that all changes in phenotype during life are not inheritable?

This came up in a talk with a friend. I wanted to clear this doubt. I've read about it before and did again after her remark (my thoughts didn't change: her concept is Lamarck's, not Darwin's), but ...
12
votes
5answers
3k views

Can any protein be phosphorylated?

I am working with an Arabidopsis mutant with an F-box protein knocked out. It has been shown that F-box proteins targets must first be phosphorylated (Skowrya et al., 1997). I have heard of ...
12
votes
4answers
282 views

Online repositories of scanning electron microscope photographs?

I have looked at every single Wikimedia commons photo in the category 'scanning electron microscope'. Unfortunately, I could not find any other repositories of such photos, but I would readily look at ...
12
votes
4answers
2k views

Do any organisms recycle their own waste internally?

I thought of this question yesterday and it turns out it's surprisingly hard to Google.
12
votes
4answers
203 views

Are there any examples of proteins with no or minimal sequence identity, but highly similar structure?

What are they, and do they share a common ancestor? How far back in evolutionary time must we go to find them? If none are known, what computational tools might be used to search for such examples?
12
votes
3answers
218 views

When are population dynamics models useful?

When are population dynamics models useful? There seems to have been a lot of research about it, but how does it help? If I need data about how a population will evolve under what conditions, I need ...

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