2
votes
2answers
43 views

Recommendation of a comprehensive book on the history of medicine

I was wondering if somebody could recommend a book on the history of medicine, be it comprehensive or an introduction to the history of medicine. I know there are a lot of medical books that cover ...
5
votes
3answers
194 views

Why don't flies avoid the motorway?

Flies have a short lifespan, therefore evolution should technically happen over a shorter period of time (years). Flies die all the time from getting hit by cars on the motorway. Those flies that ...
8
votes
1answer
124 views

How realistic is to use DNA for long term storage?

This is mainly a followup question to the recent paper Next-Generation Digital Information Storage in DNA. Personally, while I agree about the data density of the format, I can't help point out the ...
-2
votes
1answer
77 views

What causes mutations in regulatory genes? [closed]

In detail, what causes mutations in regulatory genes?
2
votes
1answer
113 views

In cancer, why do cells duplicate themselves?

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?
8
votes
2answers
3k views

What is the concentration of ATP in an average cell?

Can someone give me some references showing the average concentration of ATP in a cell?
5
votes
5answers
278 views

What is the lowest common denominator of cancer?

What is the lowest level attribute that all cancers share? Also, what is the highest level attributes that all cancers share?
4
votes
1answer
99 views

How to quantitatively measure work done by a biological system?

Thermodynamic efficiency can be expressed as the ratio of Work done(W) to Energy invested (Q). Thermodynamic efficiency= W/Q How can one measure work done by a ...
18
votes
3answers
1k views

Is “computational biology” different from “bioinformatics”?

Are "computational biology" and "bioinformatics" simply different terms for the same thing or is there a real difference?
4
votes
1answer
387 views

Why do rod cells not recover after bleaching upon exposure to bright light?

I'm confused as to why, when exposed to bright light, rod cells cease to function. I understand that exposure to bright light bleaches all of the rhodopsin, but...so what? Why doesn't the bleached ...
11
votes
1answer
1k views

Given ATP synthase's structure, how can 3.33 protons ultimately synthesize one and only one ATP?

I am familiar with the structure and function of ATP synthase, but one small detail doesn't seem to make sense. It also happens to be a detail that seems very hard to express. Depending on the ...
3
votes
1answer
110 views

Optimization of annealing temperature

I am trying to optimize annealing temperature for some primer pairs. I have tried optimization using cDNA, genomic DNA, Taq polymerase, phusion polymerase etc., but every time I am either getting ...
2
votes
3answers
276 views

Where can I find a list of diseases and their incidence?

Say I am studying a particular disease and I know that its incidence is 0.8 per 100000 children below the age of 18, how would I find the incidence of a whole bunch of other pediatric diseases (or ...
20
votes
5answers
896 views

Why did life not evolve to use radio?

We use electromagnetic communication everywhere these days. Cell phones, wifi, old-school radio transmissions, television, deep space communication, etc. I'm curious about some of the possible ...
6
votes
1answer
68 views

(Rough) Model for DNA evolution in E. coli genes

I need a model of in-gene DNA drift. I'm not interested in bacterial phylogenies alone. Here is what I understand: Sequences corresponding to genes have both exons and introns, but in bacteria the ...
6
votes
1answer
372 views

What is Mendelian Randomization, and how is it used to infer causality in epidemiology?

Studies of human traits and diseases are inherently confined to observational studies, known as epidemiological studies. This can make it very hard to determine what actually causes a particular ...
6
votes
3answers
129 views

What gaseous substances do humans emit?

Other than CO2 and Methane what other gases do humans produce or emit? For example, does skin decomposition, or aerobic respiration emit any special gases that people don't normally realize or know ...
8
votes
1answer
345 views

Why aren't mitochondria and plastids considered symbiotes of eukaryotic cells?

Mitochondria and plastids have their own DNA, their own membranes, and their reproduction is not tied to the reproductive cycle of the host cell. However, they are considered to be organelles rather ...
8
votes
1answer
105 views

How much energy does a cell expend maintaining its contents?

In software engineering, an analogy is sometimes made using biological cells. I would like to know whether it has basis in fact. People say (Alan Kay was first) that "objects" in software should be ...
10
votes
3answers
327 views

Athletes: nature vs. nurture?

Having watched a lot of olympians the last few weeks, I was struck by how many of them have actually spent their wholes lives/careers training for their one event (be in running a marathon, or ...
4
votes
1answer
71 views

During human ageing, which immune cell sub-types are most affected?

It is now well established that human ageing is accompanied by an increase in systemic, low-grade (chronic) inflammation, sometimes termed inflammaging (Franceschi, 2007). This is in part due to more ...
8
votes
2answers
2k views

What is the life cycle of a wart?

There doesn't seem to be a lot of information available on research done on warts. What is the life cycle of a wart? How does it spread? -- specifically how does it recruit cells to spread it? What ...
4
votes
1answer
235 views

Why does muscle tissue have relatively constant AMP + ADP + AMP?

I was going over slides of energy expenditure in muscle cells. It mentions that in muscle tissue, the cell's energy charge ([ATP] / [AMP]) is the principle factor controlling glycolytic activity, and ...
2
votes
1answer
89 views

How do parasitic fungi sense optimal fruiting conditions from inside the host?

Question is pretty straight forward. Are there generally any chemical cues?
6
votes
1answer
132 views

Why are pilots under the illusion of gaining altitude without doing so?

We had a lecture about the balancing systems of the body (mainly the otolith organ / semilunar canals) in which a case was described where a pilot crashed into a ship. He was supposed to keep his ...
13
votes
2answers
807 views

Is the EC50 of an activating protein for an enzyme a good indicator for the binding affinity Kd?

We work with a membrane protein system where measuring the affinity between the enzyme and the upstream activating protein has been difficult, and when measured in detergent solution, it is almost 100 ...
4
votes
1answer
94 views

Assembly of metagenomic data

I'm trying to assemble metagenomic data that comes from termite guts. The sequences comes from SOLiD and no paired, so the reads are extremely short (25bp). I have tried multiple assemblers (CLC, ...
4
votes
0answers
64 views

What is the frequency of double-hets between parent and child?

Say both parent and child are genotyped for all SNPs. In this setup we are only looking at variant positions between one parent and child - so neither parent nor child are homozygous reference (no ...
11
votes
1answer
189 views

Salmon returning to lay eggs

To spawn, salmon return to the river in which they were born. Is it because the individuals remember the specific river, or because populations are genetically conditioned to follow specific ...
8
votes
1answer
165 views

Is there a program that simulates biology on a molecular level?

Is there a computer program that simulates biology on a molecular level? Software that has rules that simulates the rules of molecular-biology?
4
votes
1answer
154 views

Is there a way for a 19th century scientist to prove that the octopus doesn't revive?

Say a sophiscated scientist in the 19th century noted that applying soy sauce on a dead octopus leads to movement of the legs, as a result of the voltage differences resulting from the salt in the soy ...
4
votes
1answer
663 views

Is it possible for a substance to be absorbed by the hair or the scalp?

I've heard that the aplication of Monovin A in the hair would allow it to grow faster. Monovin A seems to be only A vitamin, according to the first website. Could the application of A vitamin in the ...
5
votes
1answer
86 views

Free-flowing cells and those that are stuck together?

I've been thinking about the development of an embryo from the zygote stage. How is it that when cytokinesis takes place at that stage, the cells all stick together in a little ball, but later in ...
6
votes
1answer
114 views

How are synaptic vesicles brought to the synapse?

I'm reading about how synaptobrevin is used to identify synaptic vesicles for tethering near the synaptic cleft. Since neurons have a synapse and dendrites, I'd like to know how exactly the vesicles ...
9
votes
1answer
116 views

Plumage as indicator of health in birds

Anybody know which traits of bird plumage are accurate indicators of a birds health? For example feather coloration, feather brightness, amount of feather wear, number of feathers, moult timing, moult ...
7
votes
2answers
83 views

Exactly which amino acids are phosphorylated in higher plants during state transitions?

I know it is usually stated as the threonine residue near the N-terminus of either light harvesting complex (lhc) b1 or lhcb2, but if this is somehow lost, say in a mutant, is the system flexible ...
4
votes
1answer
549 views

When is the lactase in lactose-free milk active?

Recently we have started suspecting that one of our children has hypolactasia (lactose intolerance), and so accordingly I have had my first exposure to lactose-free dairy- and dairy-like products. In ...
12
votes
1answer
241 views

Evolution of long necks in giraffes

In this question, the OP uses giraffe necks as a supportive example of evolution. Is the mechanism described in this post accurate? At some point, I thought I remember hearing that giraffes did not ...
28
votes
1answer
656 views

What is itching?

What exactly at the molecular level is itching? What physiological function does itching serve, if any? I cant remember the reference but a PLCb3 null mice lost the itch phenotype, so presumably it is ...
4
votes
3answers
1k views

Is the theory of evolution being disproved by bats?

For some species the Darwin's theory evolution makes perfect sense. I can easily imagine how, for example, the giraffe has evolved to its current appearance: the natural selection was favoring ...
2
votes
1answer
286 views

How does the brain instinctively know the math behind Newtonian Physics?

A 10 year old child does not have the intellectual power to accurately calculate the energy required to throw a ball an arbitrary distance. Yet they are able to accurately throw a ball at a ...
4
votes
1answer
52 views

Where can I find histograms and tables of prevalence of mutations in cancer?

At some point in the past I found a cancer portal site which had aggregated data for the relationships between various mutations and their prevalence in cancer types and tumor data. The data was ...
6
votes
1answer
557 views

Is there a biological basis to physical attraction?

Is there something encoded within us that makes us attracted to, e.g., someone taller or shorter with blonde or brunette hair with green or blue eyes? Or, is this phenomenon completely based on ...
10
votes
2answers
2k views

What is the difference between naive and adjusted p-values in a GWAS study?

What is the difference between a naive p-value and an adjusted p-value in the results of a GWAS study? See from this paper: After Bonferroni adjustment, a single gene, DCTN4 (encoding dynactin 4) ...
10
votes
2answers
200 views

Shortest strings not present in the human genome

What length are the shortest strings of DNA not present in any known person's genome, and what are they? And is there a database online by which I could find this out?
8
votes
1answer
163 views

Why does the gender of the parent species determines the species of a hybrid offspring

I've read a little about hybrid animals, and have been amazed by the fact that the gender of the parent species determine the species of the offspring, in some hybrids. A male horse and a female ...
6
votes
1answer
99 views

What is the biological mechanism linking temperature and probability to be infected with a virus?

It is common knowledge that when you're cold you could get a cold. What is the mechanism linking temperature and viral infection?
3
votes
1answer
342 views

Can parents' learned traits be transmitted genetically?

I am wondering whether a behavioral trait (e.g. fear or stress experienced in the lifetime of the parent) can be transmitted genetically to its offspring? I understand that a behavioral tendency for ...
9
votes
2answers
591 views

Is there any biological reason that professional swimming is dominated by white people?

I suppose that the question should be turned around to "Why is it extremely rare to see black people competing in professional swimming?" because it is the absence of this phenotype while watching the ...
10
votes
1answer
347 views

How would I explain different properties of the same protein in different species?

I recently finished an experiment where I analyzed the rate of ATP hydrolysis of Heat shock protein 104 in three species of fungi. They have shown to all have different rates of ATPase activity. How ...

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