2
votes
1answer
42 views

How is protein cavity centre related to binding?

I am confused and I have the following questions: 1. What are (in the context of article below) protein cavity centres? 2. How are they related to binding? (Automated identification of protein-ligand ...
0
votes
1answer
13 views

Genetic notations

Genetic testing revealed these two mutations (hypothetically): IVS11+6G>A and IVS11-4G>A Could you please explain every part of this notation, especially "+" and "-" signs.
3
votes
2answers
50 views

What physical force attracts the anti-codon on tRNA to the codon on mRNA during translation?

What physical force attracts the anti-codon on tRNA to the codon on mRNA during translation? I know that these two bond together, but what actually makes the tRNA move through the cytoplasm to the ...
-1
votes
1answer
19 views

What letters does RNA Primase Read/write?

I know that the direction of RNA primase read from 3' to 5' and write from 5' to 3'. However I am unable to find the letters RNA primase read or write? And why do the letters bond that way?
0
votes
3answers
55 views

How does frame-shift mutation not absolutely ruin the organism?

I'm a bit curious as to how frame-shift mutation works. If you shift one amino acid towards another. How does this not affect the entire chromosome? Wouldn't this mean that the organism would be ...
1
vote
0answers
48 views
+200

lentivector security

Lentivectors are widely used in molecular biology, most commonly to transduce in a stable way a desired gene. These vector system takes advantage from the ability of viruses to introduce their own ...
6
votes
2answers
94 views

Why do only humans commit suicide?

Why is it that only humans commit suicide? Many animals do 'brave' things to protect their children or family, and some male spiders sacrifice themselves so that they can impregnate the females. ...
3
votes
2answers
31 views

Macrophages and what they consume

Do macrophages in the dermis consume any foreign invader to the body, or simply pathogens and cellular debris? For example, would macrophages consume vitamins or medications injected into the dermal ...
6
votes
0answers
37 views

Biopython - Big Discrepancy Calculating RNA melting Temperature over Literature

I experience big discrepancies when calculating melting temperature of RNA 7-mers with Biopython over values generated by a popular algorithm. I tried the nearest neighbour algorithm with RNA and ...
3
votes
2answers
31 views

Antibodies stored in freezer instead of fridge

someone from my lab put all the box of antibodies in the freezer instead the fridge can I hope they will still work??
0
votes
0answers
17 views

Are gene-specific transcription factors necessary for proper expression of a eukaryotic gene? [on hold]

I think the answer is no because gene-specific transcription factors provide an extra boost to transcription but transcription can still go on without them. Am I correct?
7
votes
2answers
802 views

Do males of all sexual species have Y chromosomes?

I know for instance some cells are sexual, so, this got me wondering, do the males of all species that have distinct sexes have Y chromosomes?
2
votes
1answer
52 views

Are there any examples of how to apply evolutionary models?

Apologies if this question it too open-ended; evolutionary biology is not my primary field. I have been reading a lot about the use of statistical mechanics in analyzing evolutionary dynamics. As an ...
1
vote
0answers
19 views

What will happen to transcription if histone acetyltransferases are removed from a eukaryotic cell?

If HATs are destroyed in a eukaryotic cell, how will gene expression level be affected? Will all gene expression be affected or just be slowed down and most gene will still be expressed?
0
votes
1answer
27 views

(Genetics) Is a silencer the same as gene silencing (heterochromatin)?

Is silencer the same as gene silencing? I know that gene silencing refers to those heterochromatin concentrated at the telomeres or centromere. It is also related to methylation. But what about a ...
0
votes
1answer
11 views

Can the Staph streak method be used for culturing Neisseria on blood agar?

What I learned in class: Normally chocolate agar is needed to grow Haemophilus and Neisseria. The Staph streak technique can be used for culturing Haemophilus on blood agar by allowing the Staph to ...
6
votes
1answer
35 views

Chromosome picture, how to interpret?

In this guide i was reading for annotations, there is a diagram of chromosomes of D.mel, I am confused as to why the chromosomes are all attached to one another, is this picture taken in a certain ...
1
vote
0answers
10 views

Linkage Disequilibrium in GWAS

I see a lot of studies on GWAS not filter out for linkage disequilibrium or even make the slightest mention of it. Why is this the case? I would imagine that you want to keep SNPs that are only in ...
3
votes
0answers
36 views

Neural coupling between Pinsky-Rinzel (reduced Traub) neuron with a Wang-Buzsaki neuron?

I have read two papers related to modeling neurons. The first one is the paper by Pinsky and Rinzel and the second one by Wang and Buzsaki. The first mentioned neuron model is a excitatory neuron ...
0
votes
1answer
39 views

Can you measure plasma glucose with a regular glucose meter?

I'm wondering if plasma glucose can be measured with a regular glucose meter and strips like this. I know these meters are normally used to measure whole blood glucose, but can they measure plasma ...
0
votes
0answers
24 views

Some kind of better oxygen-transport protein or something… Can you help me find it?

I remember reading about artificial or man-made, oxygen-transport protein that is somehow an improvement on hemoglobin, and that it is possibly immune to sickle-cell anemia, or something... But I ...
1
vote
0answers
15 views
+100

drosophila biarmipes gene annotation, transposable element?

When doing an annotation of a contig31 of drosophila biarmipes genome, the gene predictions(in orange, red, green, tan, blue, brown, and gray) picked up numerous possible genes in the area circled in ...
6
votes
3answers
50 views

How animals know which is carnivorous and herbivorous?

Deer ran away from tiger or cheetah, but not from giraffe or zebra. where did deer learn this? How animals know which is carnivorous and herbivorous?
1
vote
0answers
40 views

Consuming animals by slaughtering vs injecting barbiturates?

In "Least painful way to die" we get an answer ... Companion animals (e.g., dogs and cats): injected barbiturates are recommended Laboratory animals (e.g., mice and rats): injected ...
4
votes
3answers
163 views

Gametes of two different species

I always wondered why gametes from two different species dont fuse together to form an offspring. eg a donkey (sperm) and a female dog (egg) I know this is not possible but I'm just curious.
3
votes
4answers
404 views

Does any animal species have two sexes and more genders?

Does it exist any animal species that have two sexes and a kind of different internal diversification in two genders or more? I mean no something like different-task-based diversity but something ...
5
votes
2answers
86 views

Proteins that give color (without fluorescence)

Is there proteins that have strong color, that could be seen without the need of UV and with naked eyes (with white light) - in mammalian cells? Searching for reporter, something like GFP, but that ...
11
votes
0answers
225 views
+100

How does Sodium Valproate cause neural plasticity

I have been reading a fascinating paper: Valproate reopens critical-period learning of absolute pitch 18 individuals were given Sodium Valproate (VPA) for a fortnight during which they trained on a ...
4
votes
1answer
118 views

How does LCR compare to Assembly PCR

The question pretty much explains itself. How do the two methods compare? I've always used Assembly PCR but the method is prone to mistakes and I'm curious how it compares to Ligase Chain Reaction ...
10
votes
3answers
6k views

Why is PEG important for efficient yeast transformation?

One way to do an yeast transformation is by using lithium acetate, a single-stranded carrier DNA, and PEG (1). I was wondering why is the polyethylene glycol important for the efficient ...
3
votes
0answers
22 views

Is the number of stamens always 9 for geranium?

We are studing in class the reproduction of plants. We start the lesson by observing some components of flowers, it was the Géranium. First of all we start counting the number of sepals , petals and ...
0
votes
0answers
19 views

What is a “NuMA protein”?

I just got out of a lecture on mitosis and this part was incredibly confusing. After searching my textbook it doesn't cover it that well either. The professor mentioned a NUMA protein that is ...
1
vote
1answer
32 views

Limited space for animals - how is that bad?

I am writing an English paper wherein I have to appeal for change in the way humans treat wildlife. I was initially given a situation wherein I took a ferry in a certain area and saw a dead baby ...
1
vote
1answer
19 views

How does inbreeding depression cause infertility?

My textbook states that repetitive self-pollination in the plants cause inbreeding depression which causes infertility thus plants develop techniques called outbreeding devices to encourage ...
1
vote
0answers
28 views

Importance of organic chemistry in biochemistry/molecular biology? [on hold]

I'm halfway through my biochemistry and molecular biology degree in Australia and i'm concerned about a lack of organic chemistry. My friends studying biochemistry back home in Canada take units upon ...
0
votes
0answers
20 views

Determining the percentage of the query of an alignment from a BLAST output

Given this BLAST output, how can I determine the percentage of the query sequence in the alignment? I know that it's also referred to as 'query cover' but I can't seem to find anything online that ...
0
votes
0answers
9 views

Over what range do Thyroid Stimulating Hormone (TSH) levels tend to fluctuate over the course of a day?

I understand that the majority of doctors consider the TSH test "the gold standard" for measuring thyroid function (examples stating that literally are here and here). The reference range for what is ...
1
vote
1answer
27 views

How does the partial pressure of oxygen affect mental focus?

On this Wikipedia page it says that lower oxygen levels can cause light-headedness. Is there evidence that higher partial pressure of oxygen can improve mental focus?
8
votes
4answers
1k views

What is the difference between a circular and a cat's-eye pupil?

I've been to local zoo the other day and one lizard caught my attention: its pupils are circular, which, I thought, is not usual for reptiles. Turns out it is, but now I can't find any explanation on ...
4
votes
1answer
42 views

Multistability in the lactose ultization network

Reading the paper here, I'm confused about the production of figure 4d. The method of production is detailed in the supplementary information under the heading "Theoretical phase diagram". ...
1
vote
1answer
31 views

Recommend good conversational books to learn about cell and developmental biology or biochemisty?

I'm an engineer by training and teaching myself the basics of cell and developmental biology. I'm using Scott F. Gilbert's Developmental Biology and Alberts' Essential Cell Biology right now, and they ...
-1
votes
0answers
19 views

molecular biology equilibrium question [on hold]

Can anyone help me with this question, maybe I missed something but I'm not sure what laws or approaches I need to take. Any light would be appreciated. EDIT: from the comment section from the OP's ...
0
votes
1answer
21 views

Do restriction enzymes on read 3' to 5'?

Every chart of palindromic restriction enzymes I've seen lists their restriction sites from 5' to 3', something like this: EcoR1 cuts GAATTC between the G and A: 5' NNNGAATTCNNN 3' --> ...
1
vote
0answers
44 views

Measuring a plant's electric activity any instructions where to place electrodes?

I would like to measure a plant's electric activity / voltage, I've looked online to find out where to place the electrodes and what type of electrodes to use but they seem to very wildly. Any ideas? ...
6
votes
2answers
61 views

The effect on the efficacy and potency of a non-competetive antagonist binding to the active site of the receptor (dose-response curve)

According to the book "Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy" by Golan et al, non-competetive antagonists can bind to both the allosteric site and the active site. I ...
0
votes
0answers
39 views

Does embryonic development mimic (partly at least) the evolution of organisms on earth?

What do we know about the forces/mechanisms which lead to this seemingly "fast forward" evolution stages of the embryo? What are the theories dealing with this idea?
-1
votes
0answers
37 views

Is there a way to tell what the surface of a planet is like? [migrated]

Kepler-442b I'm doing a project in which I need to find a planet within our galaxy that might be habitable. I found this planet that is within its solar systems habitable range, and due to research I ...
10
votes
4answers
5k views

How does sodium in one's diet affect blood pressure?

Due to high blood pressure, my doctor has recommended I go on a low-sodium diet. So, that got me wondering what it is about sodium that drives this recommendation? What does sodium do to a body ...
13
votes
1answer
69 views

Why does mint oil feel cold on the skin?

When putting (japanese) mintoil on the skin it produces a cool feeling. You can experience this, when adding it to your bath or using a spray with mint oil on your skin. The cool feeling occures ...
6
votes
0answers
35 views

Basic Modelling in Quantitative Genetics

I am pretty bad in thinking quantitative genetics models. I am trying to get some basic understanding of modelling the evolution of a quantitative trait. I am therefore asking for help to analyze a ...

15 30 50 per page