1
vote
1answer
10 views

What is the connection between exercise and muscle growth

From a physiological perspective, all that is done during exercise is the expending of energy in the form of ATP to fuel muscle contraction and extension. When I looked up why muscle grow due to ...
0
votes
0answers
10 views

What is genodiversity good for?

I saw some documents which were trying to say that they can prove via sweat smell selected by women that humans are developed to find a partner with similar genes. At the first glance, I refused it as ...
0
votes
0answers
4 views

How long has to be DNA?

We have learned that the same information are saved in the DNA int the same place. So when DNA split and connect again, it have to fill into the atom-exact place?
2
votes
1answer
30 views

How long do the periods of systole and diastole last?

The background to this is i'm doing some work using ECGs for an animation of the heart and i'm having trouble defining the end points of these periods, particularly diastole. Currently, the only ...
1
vote
1answer
10 views

Are more molecules of ADP than inorganic phosphate returned to the light reaction in photosynthesis?

During the dark reaction, 9 molecules of ATP are consumed for every 3 carbon dioxide molecules, yet only 6 molecules of inorganic phosphate ultimately leave the cycle. Does that mean that there is a ...
3
votes
1answer
64 views

Involuntary twitches and apnoea during early phases of sleep

I assume most people either experienced or have seen people with the following phenomenon: in the early phases of sleep sometimes involuntary twitches occur that usually accompany the pause of ...
6
votes
1answer
88 views

How well do we notice asynchronicity?

I'm stopped at a stoplight and, with nothing to do, my thoughts wander to the timed don't-walk sign that governs any pedestrians who might wish to cross the street I'm driving along. I can see two ...
-2
votes
0answers
9 views

Spring turnover in lake

During spring, the water at the top is at 0 degrees, and that the bottom is at 4 degrees (with a small middle part in between with intermediate temperatures). In spring as water warms at the top, its ...
3
votes
2answers
45 views

Are there human cells, apart from red blood cells and platelets, without a nucleus?

I know that blood platelets and erythrocytes do not have a nucleus. Are there more cells in the human body without a nucleus, such as pancreas, cartilage, or lung cells?
4
votes
1answer
76 views

Biological origin of shuddering during sleep

What is the biological origin of the following behavior: Sometimes, during the early, formative phase of sleep (when you have a gradually dimming consciousness of what all is happening around), you ...
4
votes
1answer
46 views

When is Water Produced During Photosynthesis?

The formula for photosynthesis is: $$6CO_2+12H_2O \rightarrow C_6H_{12}O_6+6O_2+6H_2O$$ I can count the carbons, the waters on the reactant side, the oxygens, and the glucose, but I cannot seem to ...
0
votes
0answers
16 views

Why do fingers swell during winters? [on hold]

Why do fingers swell during winters (of temperature 5-15 degree celsius)? During winters mine and many others's fingers swell. is it due to blood circulation or what?
2
votes
1answer
21 views

How Does NADPH Reduce 1,3-BPG?

If NADPH returns to being NADP+, then that means one proton and two electrons have been incorporated into 1,3-BPG. If only one proton and one electron were attached to the carbon in 1,3-BPG (removing ...
3
votes
1answer
19 views

Quantitative Trait Locus process?

I do not seem to understand the concept of Quantitative Trait Loci(QTL's), can anyone explain it to me in detail? Reading the wikipedia article helped somewhat, but I do not understand it well. What ...
2
votes
1answer
41 views

Modeling inclusive fitness

Consider a population of two altruist with coefficient of relatedness $r$. The average inclusive fitness of this population will be $w_{0} + br -c$. Like in this example, assignment of inclusive ...
1
vote
0answers
12 views

Why do flagella form a bundle only when they rotate counterclockwise during chemotaxis?

During Chemotaxis in bacteria with flagella, the flagellar rotation dictates how the cell moves. If the flagella rotate counterclockwise, then they form a bundle at one end of the cell (---O) and ...
2
votes
1answer
110 views

Does enzyme Km comparisons make sense?

I have encountered comparisons of the Michaelis-menton constant (Km) a few times. Generally speaking if Km of an enzyme is higher, then it's affinity to its substrate is lower. How does this make ...
0
votes
0answers
29 views

Protein Folding [on hold]

I am planning to do my Masters thesis in Biophysics in the topic of "Thermodynamics of Protein folding " It would be great help if anyone could suggest me the proper way to start with like which ...
3
votes
1answer
36 views

How can we create a living dinosaur using DNA technology?

I'm wondering what would we need to do to create a living dinosaur using DNA technology? If it is not possible with current technology, will it ever be feasible? In the movie Jurassic Park, ...
-1
votes
1answer
23 views

Standard DNA extraction protocol [on hold]

Which DNA extraction protocol in plant and other biological complex is acceptable method for article?
0
votes
1answer
20 views

Does the term “upper extremity” include hands?

I see on http://en.wikipedia.org/wiki/Upper_limb that the term "upper extremity" seem to include hands. However, in many hospitals, there is a "Hand & Upper Extremity Service", which would tend to ...
3
votes
1answer
24 views

Analyse a ECG graph

I have a project about extracting features from a homemade ECG. I need PQRST points from the heart beat. The ECG I'm using have 3 electrodes that attaches to the chest. The problem is I don't know ...
7
votes
1answer
34 views

When do plasmids replicate relative to its host cell cycle?

For plasmids is so much shorter than their host cell's genome (about 1/1000 in my case), it will take only 1/1000 time for it to replicate. With respect to cell cycle, when will that replication ...
4
votes
1answer
85 views

I have a black tiny bug crawling all over the house

This bug is crawling all around the house it stays within the shadows and moves very very slow, i have never seen it jump or run, it just moves very slowly P.S. those bugs as u can see are smaller ...
7
votes
4answers
223 views
+50

Introductory biology text for an outsider

I'm a maths major and I have an interest in learning biology. I know very, very little; I know how babies are made and that's about it. Could anyone recommend a stimulating text to read for it's own ...
3
votes
1answer
98 views

How does rate of evolution/innovation scale with population size?

I understand that there will be many other factors that affect rate of evolution/innovation. However, other things being equal, how will the rate of evolution vary between two populations of different ...
3
votes
0answers
21 views

What is this frog?

(Man, there's a lot of 'What is this X?' questions here...) I saw this while walking in Cyprus in early April. It was at about 100m altitude, in woodlands, sitting in the sun on a concrete step ...
1
vote
0answers
43 views

Where can I find mutation datasets for cancer (other than TCGA)?

My lab has been using TCGA data (somatic mutations and clinical data) to develop panels of genes and of mutations we expect to see in certain cancer populations. We'd like to validate our panels by ...
2
votes
1answer
236 views

Using RNA-seq to compare gene expression across patients instead of between Control and Experimental conditions

I am working with RNA-seq data from the Cancer Genome Atlas TCGA and I have been reading about how people have compared gene expression levels measured by RNA-seq. Many of the papers I have read talk ...
3
votes
1answer
41 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
3
votes
1answer
40 views

Why do some proteins “use” a beta barrel structure instead of alpha helices in transmembrane space?

Most proteins are fixed in the membrane by alpha helices. But some use beta barrels. Wikipedia describes beta barrels as used for porins, preprotein translocases, and lipocalins. To me, a coiled coil ...
0
votes
1answer
463 views

TCGA data, and bioinformatics design questions for SNP/ mirna analysis

It's my first time posting to this forum but was looking for some help on the data aspects of this project. My tools of choice would be in python/R . Goal: I'm looking to create a disease specific ...
2
votes
0answers
92 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
1
vote
1answer
248 views

Mapping a mutation to known SNP, 3' UTR, miR

I've parsed out a very large TCGA cancer ssm (single mutation file) file to give me the essential information. The ssm is in the following format: ...
0
votes
1answer
85 views

How to select genes before log2 ratio on a RNASeq gene expression matrix, based on signal median

I want to transform a TCGA mRNA expression matrix (in linear data format) to log2-ratios and then run a feature (gene) selection, selecting the 1000 most variant genes (genes with higher standard ...
4
votes
2answers
55 views

Relative microRNA comparison from from TCGA data?

I have a conceptual question that I was hoping someone could answer. Can I say that microRNA A is expressed x-fold greater than microRNA B directly from the TCGA miRseq data? Can I do this after ...
1
vote
0answers
21 views

What's a good simple test for cDNA library quality?

How do I assess the quality of a cDNA library? I want to clone CDS copies of genes from a library, but I don't know what's a typical expectation of getting a full length clone even for a shorter ...
5
votes
1answer
65 views

How does the brain cool itself?

Thoughout life everyone tells you that brain is essentially a computer but just like computers your brain would create immense amounts of heat by being in use, so if that's the case how does it cool ...
2
votes
2answers
572 views

TCGA gene expression data are missing matched normal

I'm trying to use the TCGA data portal to get gene expression data for cancer tissues, but I'm not sure what "Tumor matched normal" means. It is unclear to me if the values are already compared to a ...
0
votes
0answers
86 views

How TCGA CNV values are calculated?

When I download CNV SNP array data for ovarian cancer from TCGA data portal, I see some very small numbers like -5, -6 in the "Segment_Mean" column of the segmentation data files. I am very new to ...
9
votes
1answer
118 views

Circadian Clock During a Flight

I am interested to know how does our Circadian Clock respond (and its resultant changes if any) when we are traveling across Time Zones? UPDATE 24th April I am reopening this question as the ...
3
votes
1answer
32 views

Photolysis of Water?

In chemistry, I studied the decomposition of water as being $2H_2O_{(l)} \rightarrow 2H_{2(g)} + O_{2(g)}$. However, when water is split, the equation is $2H_2O_{(l)} \rightarrow 4H^+ + 4e^- ...
6
votes
2answers
69 views

Latency differences between our senses

I would be interested in knowing how long it takes between the moment something touches our skin and the moment something is activated in the brain. Also how long does it take in total until we ...
3
votes
0answers
33 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
2
votes
1answer
19 views

Why are 2 electrons transported from photosystem II at the same time?

I only know that electrons are captured by the primary electron acceptor and then go through the electron transport chain, ultimately ending up at photosystem I. But why do 2 leave photosystem II in ...
6
votes
0answers
30 views

Biostatistics: Pollen dispersal directionality

What Information am I looking for? Think about a tree that is sending pollen all over the place. Because of wind, most pollen grain will go toward one direction. Imagine, we split the 2D area around ...
8
votes
1answer
72 views

Why can good music raise goosebumps?

Listening to really good music right now, I was wondering why it raises goosebumps. Is there any physiological reason for this reaction to specific wavelengths or something? EDIT: Due sometimes ...
-1
votes
0answers
19 views

Protein secondary structure prediction

I'm trying to predict the protein secondary and 3-D structure for the sequence [Q1NN20] and need some help getting the ball rolling. I'm getting confused with how and when to use Jpred, swiss-mod, ...
3
votes
1answer
18 views

Does the palate truly house the sense of taste?

Source: Your “palate” is the roof of your mouth, and by extension, your sense of taste. I was reading Etymonline's entry for palatable {adj.}, which cites and derives from palate {noun}: ... ...
0
votes
0answers
27 views

The future of human evolution [on hold]

While in college I read a book that said human have stopped evolving internally, but rather we now evolve externally in the form of technology, ie instead of growing claws we make a knife. Is this ...

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