9
votes
0answers
332 views

Additive genetic variance components from LMER in R

I've set up some dummy data in R which makes 40 genetically related lines, they are all siblings within a line so are genetically related by a factor of ½ thus additive genetic variance should be ...
7
votes
0answers
71 views

Biopython - Big Discrepancy Calculating RNA melting Temperature over Literature

I experience big discrepancies when calculating melting temperature of RNA 7-mers with Biopython over values generated by a popular algorithm. I tried the nearest neighbour algorithm with RNA and ...
7
votes
0answers
62 views

Expected time for a neutral allele to reach a frequency of $p_1$ when starting at frequency $p_0$

Kimura and Ohta (1968) showed that the expected time for a neutral allele to reach fixation (given that it will reach fixation) is $$\bar t(p_0)=-4N\left(\frac{1-p_0}{p_0}\right)\ln(1-p_0),$$ where ...
7
votes
0answers
137 views

Circular mRNA to produce long proteins

Ribosomes can read mRNA and produce proteins, if we somehow make a circular mRNA for the ribosome to bind onto, it will make infinitely long "proteins", (since ribosomes can make very big proteins, I ...
7
votes
0answers
127 views

Do mammals develop tolerance to anticholinergics?

I know that first generation H1 antagonists, commonly known as antihistamines have anticholinergic effects. Their sedative side effects go away due to tolerance, but as for their anticholinergic side ...
6
votes
0answers
28 views

Was the recent “conservation hunt” of a black rhino supported by science?

CNN recently covered a sanctioned black rhino hunt in Namibia by Texan Corey Knowlton, who bid US$350,000 for the license. In the story, he claims that the hunt was actually supporting conservation of ...
6
votes
0answers
25 views

THYROGLOBULIN (19S) comes to a heavier position than ferritin (51S). Why?

Sedimentation values of thyroglobulin and ferritin containing iron are 19 and 51S, respectively. But, by density gradient centrifuge, it seems thyroglobulin(19S) migrates faster than ferritin(51S). ...
6
votes
0answers
29 views

What is cross-immunoreactivity, and how does it impact vaccine development?

What I understand about cross-immunoreactivity is that the antibody induced by one specific antigen is also fairly effective against another antigen. How would this be used for vaccine development? ...
6
votes
0answers
40 views

Basic Modelling in Quantitative Genetics

I am pretty bad in thinking quantitative genetics models. I am trying to get some basic understanding of modelling the evolution of a quantitative trait. I am therefore asking for help to analyze a ...
6
votes
0answers
49 views

What are the survival limitations of alcohol?

This question was inspired by watching one of the Pirates of the Caribbean movies; particularly where Jack Sparrow allegedly survives on a desert island by finding an unlimited supply of rum. I've ...
6
votes
0answers
71 views

How to define “Quasifixation” in continuous approximation of finite population?

Background Many models including the famous very first models derived by Sir Ronald Fisher in his early career, assume infinite population size. In an infinite population, an allele can rise in ...
6
votes
0answers
121 views

Does Lucid Dreaming decrease the regenerative effect of sleep?

After watching this SciShow video on sleep, I wonder about lucid dreaming. Specifically: Does lucid dreaming and associated directed agency within Lucid Dreaming decrease the regenerative effect of ...
6
votes
0answers
108 views

At which step apply a detection filter when preprocessing microarray data? (Before/After normalization, batch effects removal)

I am trying to understand what is the best practice when preprocessing microarray data using a detection filter (on scanner p-value). Suppose I have a microarray dataset that I have to normalize with ...
5
votes
0answers
42 views

Are fish roe unicellular?

Are roe (fish eggs, caviar, etc.) single cells? I have tried looking this up on google (sadly, to no avail), and I am guessing they might be multicellular (like bird eggs) or consist of one cell plus ...
5
votes
0answers
51 views

Can we make a rough estimate of the number of generations since the origin of life?

According to what we've learnt : we can approximate the number of generations since the first human pretty much like us (depending what / who we talk about). we have an idea of the series of life ...
5
votes
0answers
69 views

Does crude oil or kerogen contain ancient DNA?

According to wikipedia by the formation of oil there are a lot of organic materials present including DNA. Is it possible that this DNA is conserved somehow for millions of years?
5
votes
0answers
23 views

How did the introduction of artificial light changed the life cycle of a plant?

Plants in urbanized areas are constantly exposed to artificial light after sunset. In their natural habitat there is a more distinct day and night cycle. Since light is an important factor in a plant ...
5
votes
0answers
43 views

What is this frog?

(Man, there's a lot of 'What is this X?' questions here...) I saw this while walking in Cyprus in early April. It was at about 100m altitude, in woodlands, sitting in the sun on a concrete step ...
5
votes
0answers
55 views

Why do we get tired

At the end of a day full of work, it is general for people that their eyelids start to feel heavy. Laziness takes over and we begin to yawn. We all know that we're tired at that time, but why people ...
5
votes
0answers
48 views

SDS Laemmli Gel that did not solidify

In my lab class this week my partner and I were making a SDS-PAGE Laemmli Gel. We made the resolving gel solution which was made of 30% Acrylamide, DI water, 1.5 M Tris-HCL pH8.8, and 20% SDS. We ...
5
votes
0answers
34 views

How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
5
votes
0answers
112 views

What is this mushroom?

I found a singular mushroom in my back yard, It is jet black, seems to have gills and looks somewhat like a flower do to it's upturned-ness. Sorry for not having spore colors, but I didn't want to ...
5
votes
0answers
57 views

What is this arachnid?

I came across a photo on Wikipedia depicting an Oreocereus celsianus with what looks to me like some kind of harvestman on it. The photo was taken at the San Francisco Botanical Garden. Can anyone ...
5
votes
0answers
36 views

Are there mechanisms that limit the amounts of time conjugation and F-plasmid transfer can happen? If yes, what are they?

Not all bacteria have acquired F-plasmids through conjugation. Some of the mechanisms for this are unsuccesful conjugation events (mechanical disruption), no transfer due to integration in bacterial ...
5
votes
0answers
49 views

Why is living muscle tissue seemingly able to restore its shape under force, while dead tissue is not?

When I press my finger, even with relatively little force, into beef or chicken (say, at a grocery store), the indentation remains (and I get yelled at by employees). When I hit beef with a ...
5
votes
0answers
68 views

What is the mechanism by which lamins regulate gene expression?

The heterochromatin is generally localized at the nuclear periphery (also near nuclear lamina), whereas active genes are preferentially found in the nuclear interior. Children with ...
5
votes
0answers
42 views

Some sort of Lymantriidae caterpillar?

I found this larva in Sweden in July. It was about 15 mm long. It reminded me of Orgyia antiqua that I've seen before, but smaller and with a somewhat different colouration.
5
votes
0answers
58 views

How was the cama's life expectancy computed?

A cama is a hybrid between a male dromedary camel and a female llama. The first cama was born on January 14, 1998, yet on the Wikipedia page it is said that a cama's life span is 30–40 years. How was ...
5
votes
0answers
51 views

How to measure Na/K channel activation at the membrane level?

Assume that there are two different signals occurring on the ECG - during depolarization and repolarization in the standard ECG. I was advised not to use the standard ECG in measuring the exact ...
5
votes
0answers
41 views

Effect of Aging on SA node's sympathetic fibers

I am trying to understand the effect of aging on the sympathetic fibers of SA node. I know that aging shifts the vagal curve to left in frequency due to aging. However, I am interested if aging has ...
5
votes
0answers
300 views

Which of the cell types commonly found in mammals has the greatest number of mitochondria?

This is basically a fun question, inspired by this answer on scifi.se. So, which cell type will have the greatest number of mitochondria? Obviously, I am talking about wild type, healthy individuals ...
5
votes
0answers
206 views

Genetic expression in interspecific hybrids

Referring to interspecific hybrids, I have the following two questions:- Quoting from wikipedia:- The offspring of an interspecific cross are very often sterile; thus, hybrid sterility ...
5
votes
0answers
343 views

Reason for seeing grid-like patterns when strobing a solid black-white image?

I was trying to do some stimulation for SSVEPs by strobing a solid black square and a solid white square. Weird thing was, I ended up seeing weird grid like patterns that looked like this, always of ...
5
votes
0answers
112 views

Comparative cost of RNA-seq vs sequencing full length cDNAs

I am in the process of assembling and annotating the genome of a non-model organism, using almost exclusively short read (paired-end Illumina) data. Throughput is one obvious benefit of these data ...
5
votes
0answers
76 views

effect of background selection on promoter regions compared to distant enhancers?

Has anyone looked at the effect of background selection on the levels of conservation of promoter regions compared to distant enhancers? Do promoter regions have a higher conservation due to ...
5
votes
0answers
114 views

Dimensionless number for blood volume

Comments from the question How is the blood volume of a living organism measured without killing it? by @Nico discussed that the time of blood recirculation scales with the size of the organism. I was ...
4
votes
0answers
40 views

How to seek for available genetic data relevant to ecology and evolution?

I had a quick look online. There seems to exist many different website of database archiving. Some data might be free of charge while some others might not be. I found things such as Dryad, TreeBase, ...
4
votes
0answers
20 views

Is it possible that the vapour form of propylene glycol could lower a humans blood oxygen saturation by the manner in which N2O does?

My understanding is that by inhaling nitrous oxide leads to the body not being able to take in as much oxygen as it usually would. Is it possible that a heavier soluble gas such as the vapour form of ...
4
votes
0answers
35 views

Does anxiety about weight or eating cause people to become overweight?

A while ago I saw this TED talk about the futility of dieting. The speaker suggests that a body maintains a homeostatic weight point and returns to that weight after dieting has stopped: Turns out ...
4
votes
0answers
42 views

Horizontal gene transfer from humans

It is known that some viruses embed themselves in the human genome. Is there a mechanism by which human genes can be transferred to other animals or plants by means of viruses shuttling them from ...
4
votes
0answers
41 views

Does breath-holding cause permanent brain damage?

My question is: Does voluntarily holding your breath at atmospheric pressure for a few minutes can cause brain damage? I'm talking about periods of time around 3 minutes. I've read there are some ...
4
votes
0answers
22 views

Do blood glucose “spikes” contribute to insulin resistance, or is prolonged elevation required?

There's increasing public discussion about the health risks of chronic insulin resistance* (IR). In many cases there's a focus on high glycemic index foods that "spike" your blood sugar, which implies ...
4
votes
0answers
34 views

Case Study and speculations of Edward Mordake

I am very interested in the case of the man named Edward Mordake who lived in the 19th century. In particular, he had two faces. If you have not heard of this man, please, search this up as there are ...
4
votes
0answers
84 views

Phylogenetic method to detect shift in mean of continuous variable

I am currently working on a project where I study the change of a continuous morphological variable with body size (measured as body weight) across diverse taxa (insects, spiders, lizards, frogs). In ...
4
votes
0answers
31 views

Cholesterol's role in lipid uptake

I'm studying the digestion of fats and I understand that our dietary fats mostly consist of triglycerides. We absorb the fats and eventually they end up in a muscle/adipose cell for storage (as ...
4
votes
0answers
57 views

Contact Inhibition of Cell Division: Signaling Pathway

The following article refers to contact inhibition of cell division in epithelial cells, specifically MDCK cells: Collective and single cell behavior in epithelial contact inhibition. In their review ...
4
votes
0answers
46 views

DNA-DNA cross-linking with formaldehyde?

The 3C (chromosome conformation capture) technology for studying chromatin 3D organization starts by a cross-linking step using formaldehyde to find segments of DNA interacting. In my understanding ...
4
votes
0answers
60 views

How to tell if a beverage will hydrate or dehydrate?

Beverages of any type generally contain some measure of water. However, in the case of some liquids, the non-water components take more water from the human body to filter out than the water contained ...
4
votes
0answers
77 views

Is the six-layer cortex model of the mammalian cortex still the most accepted model?

I've been reading a bit about the different layers of the cerebral cortex and its clear that certainly not every region of the cortex has the same number of layers. Thus, the idea that every region ...
4
votes
0answers
39 views

Can dolphins actually communicate linguistically?

Humans use "language." By language, I mean the thing I am using right now to talk to you. I know dolphins and orcas have very complex communication systems and also seem to process linguistic and ...

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