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There can be many responses. They are important by alloimmunity (so by transfusion, transplantation, etc...), by recognizing pathogens, cancer, virus, etc... By T cell activation, the regulator T cells recognize these antigens as self, and prevent the autoimmune reaction. I guess they were thinking on MHC1 and MHC2. MHC1 shows the inside of the cells, so ...


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There are other histocompatibility antigens on the surface of blood cells, e.g. A, B, Rh, etc... (There are probably a lot more which change less by person to person, so they have lower effect on the outcome of blood transfusion.) These antigens can be recognized by immune cells as self, that's why they don't destroy them. Before complete differentiation ...


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Afaik. RA and psoriasis are probably caused by a malfunction of genes which regulate IL-23 production. IL-23 is required for Th17 cells to survive. Th17 cells produce a lot of things which result in inflammation and since TNF-α is a key mediator in inflammation and break down of joints, reducing the amount of available TNF-α reduces the inflammation. (Th17 ...



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