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A first pass answer is 662-4342. The Therapeutic index is calculated from rat tolerances; LD50 is a rare number to see for human beings(!). The toxic dose of a compound can vary widely over a class of compounds as well as does the Effective Dose (ED) midpoint (ED50). But I found this book reference: Benzodiazepines have a wide margin of safety ...


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Wikipedia quoted this article as a reference for its statement about alprazolam having a therapeutic index of 100:1, although I can't confirm that, since I can only read what's immediately available in that link. There's a figure saying less than 100:1 for diazepam though.


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Okay, I read the question wrong. Benzodiazepines do not bind to GABAA receptors universally. Thus the presumption that it inhibits the mesolimbic dopamine pathway may be wrong. They may not interact directly with said pathway at all. Many subtypes for the GABAA receptor exist. The receptor consists of 5 subunits. The following subunits are known to exist: ...



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