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A first pass answer is 662-4342. The Therapeutic index is calculated from rat tolerances; LD50 is a rare number to see for human beings(!). The toxic dose of a compound can vary widely over a class of compounds as well as does the Effective Dose (ED) midpoint (ED50). But I found this book reference: Benzodiazepines have a wide margin of safety ...


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Wikipedia quoted this article as a reference for its statement about alprazolam having a therapeutic index of 100:1, although I can't confirm that, since I can only read what's immediately available in that link. There's a figure saying less than 100:1 for diazepam though.



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