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Correct, all but one step in pyrimidine synthesis occurs in the cytosol, and purine synthesis occurs in the cytosol only. Nucleotides freely diffuse through nuclear pores but are actively transported through mitochondrial membranes via embedded membrane transport proteins (i.e. ATP-ADP translocators, GTP transporters, and pyrimidine nucleotide ...


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Seemingly the enzyme uses molecular oxygen in the reaction and one of the end products is water. This reaction scheme is more detailed and presumably accurate. http://www.hmdb.ca/reactions/3063 In addition there is also a set of papers detailing coproporphyrinogen oxidase which was also on the website, hopefully one goes into more detail on the reaction. ...


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According to one study: It was calculated that if the excretory percentage of niacin metabolites in the urine were 60%, of the tryptophan ingested, the conversion factor would be a value of 67, meaning that is 67 mg of tryptophan is equal to 1 mg of niacin. However, the study has a pretty low power with only 10 participants and an indirect measure of ...



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