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Screening programs are ruled out following sharp guidelines, like the so-called Wilson' criteria and subsequent ones provided by WHO. Specific documents regarding cancer screening have been published. A good primer on what a screening program in medicine is, can be found on wikipedia. Conventionally, a tumor is considered non capable of metastasis ...


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I think this is a difficult question for which the answer is not clear --- to my knowledge there is little data on metabolism in solid tumors, and no clear consensus in the scientific community. So I'm not going to attempt to give a definitive answer, but here's at least a few thoughts / opinions. Why transformed cells engage in aerobic glycolysis, or the ...


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The outside of the tumor has access to the most nutrients and oxygen, sometimes even the blood supply (angiogenesis). Solid tumors have this microenvironment if you will, and the human tumor microenvironment often suffers from a lack of oxygen and nutrients, and acidosis (Milosevic et al., 2004). The distance from the outside of the tumor to the core has an ...


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Short answer: Yes/Maybe More detailed answer: If the rate of cancer was uniform across cells then you would expect large mammals to more frequently get cancer than small mammals, just like buying 10 lottery tickets is more likely to make you a winner than buying one ticket. However, this correlation between mass and cancer rates does not exist, and it's ...


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There are many ways to damage the DNA of a rapidly proliferating population of cells; oxidative damage is one example—albeit a very broad example not especially specific to cancer cells, the cells we would like to eliminate. Many non-targeted chemotherapeutic drugs exploit other mechanisms of depriving cancers cells of a high-fidelity genome, therefore ...


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Since it's a very broad argument I'll try to summarize in a few sentences. First of all the sentence: Since most of the chemotherapy drugs kill cancer cells by damaging their DNAs by means of free radicals. So antioxidants, which will detoxify free radicals, should theoretically decrease the efficacy of the chemotherapy. is a bit inaccurate as of ...


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There are dozens of cell marker genes. The number refers to antigen protein from one of those specific genes. The number itself can be a result of any of a variety of things, from the order in which the protein was discovered to the corresponding antibody being the 125th antibody produced against the cell line or organism. These are often used as biomarkers ...


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Cancer doesn't have to have a profound effect on the blood. Remember that a cancer generally starts off as an abnormal tissue growth or a neoplasm. As the tumor progresses into a malignancy, it has the potential to gain or lose functions, develop new cell types that shouldn't be present in a given organ, invade other tissues, etc. Because of this, in some ...



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