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The localization of the protein kinase A (PKA) cannot be explicitly answered, since the localization depends on the activation state of the protein. Lets have a look at the protein itself first, as this is important for the activation. PKA consists of four subunits, two catalytic subunits and two regulatory subunits. See the image from the Wikipedia article ...


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It is present throughout the cytosol but can also be anchored to plasma membrane and mitochondria via indirect interactions. Can also be translocated to the nucleus. (See here). It is not called a receptor for cAMP (though the mechanism is homologous).



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