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Nice question! Oxygen is actually not needed in the Krebs cycle - it is needed in the electron transport chain that is upstream of the Krebs cycle to regenerate NAD+ from NADH (see link). However, note that without O2 NADH accumulates and the cycle cannot continue as it needs NAD+ to run.


Just to clear out some things: As stateted above, NADH is produced in catabolic reactions and is later used in the electron transport chain to obtain energy by converting NADH back to NAD+. NADPH is primarily produced in the oxidative part of the pentose phosphate pathway. NADPH is used in a) anabolic syntheses to produce cholesterol, fatty acids, ...

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