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Why cells differentiate or specialize is an ephemeral question. I'll make an attempt to answer--the more specialized cells an organism has, the better equipped that organism is to function. In a given organism, differentiation after n divisions or after t time during development is due to changes that are both intrinsic (genetic) or extrinsic ...


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SOX9 is indeed the factor which is important for the developent of the sexual organs and not only for men, but also for women. Expression of SOX9 regulates the expression of the anti-Müllerian Hormone, which inhibits the formation of the female reproduction system. See reference 1 for more details. Mutations in or around (in regulatory regions) of the SOX9 ...


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Quoting the abstract of this paper verbatim: Sox9 is an Sry-box-containing gene that encodes a transcriptional activator. During mouse gonadogenesis, Sox9 is detected in the male gonad at 11.5 days postcoitus (dpc). At 12.5 dpc, testicular cords form, morphologically distinguishing the male gonad from the ovary. From this stage onwards, Sox9 ...


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You may want to look into "Evolutionary - Developmental Biology", which deals with how an embryo develops into a grown organism. Thus, by combinatorial specifying the identity of particular body regions, Hox genes determine where limbs and other body segments will grow in a developing embryo or larva. A paragon of a toolbox gene is Pax6/eyeless, ...


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Yes. Dewing et al. (20030 found that gene expression in mouse brains differs between male and female mice about 10.5 days after the mice had sex. This occurs before hormonal contributions to brain development. They identified about 35 genes that were appeared to show preferential expression in the female brain and another 16 that appeared to be show ...


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Ok, I'm not quite sure if we are at the repairing an organ phase, but here are a few interesting examples: 1. Philip Maini at Oxford has used pattern formation to give insight into jaguar patterning: Paper. He also has a book chapter Pattern formation and wound healing that could of of interest, although I'm not sure if this is a direct application as much ...



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