7
votes
Accepted
Why does hypercalcemia cause muscle weakness, yet hyperkalemia causes muscle excitation?
You're correct about your reasoning for potassium; high extracellular potassium concentration reduces the concentration gradient of potassium across the membrane, pushing the reversal potential for ...
3
votes
Accepted
Why do V_Na and V_K stay unchanged in Hodgkin-Huxley model?
As you've figured out, the reversal potentials don't change because they're assuming the concentrations don't change. Even relative to $\mathrm{[Na^+]_o}$ and $\mathrm{[K^+]_i}$ the number of ions ...
2
votes
Accepted
Why is the ordinary cardiac muscle’s target value of the action potential 0mV?
Membrane potentials are determined by the combination of all the membrane-permeable charges, not single ions.
You can use the Goldman Equation to calculate the reversal potential for any combination ...
2
votes
Accepted
Mapping Ion Channel mRNA Copy Number to Channel Conductance
I don't have access to the paper so I can't fully evaluate the relationship you describe. I'm also neither an electrophysiologist nor a
However to answer your questions:
This to me is a solid "...
1
vote
Accepted
Why don't membrane potentials violate the principle of electroneutrality?
There is perhaps Pauling's principle of electroneutrality "each atom in a stable substance has a charge close to zero" - maybe that's the principle referred to in your book? "Close to&...
1
vote
Why is the ordinary cardiac muscle’s target value of the action potential 0mV?
Just for a Comment;
I know the Goldman equation (https://en.wikipedia.org/wiki/Goldman%E2%80%93Hodgkin%E2%80%93Katz_flux_equation), and I asked this question because I thought maybe this does not ...
1
vote
Accepted
Why is there a negative sign before voltage in the gate variable functions of the Hodgkin-Huxley model?
Voltage is a potential difference. Membrane potential is a difference across a membrane. When you calculate a difference A - B or B - A, you get a number that has the same magnitude but opposite sign. ...
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