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Short anwer 'Non-competitive active site–binding inhibitors' are called mixed-type inhibitors. These inhibitors exhibit features of both competitive and non-competitive inhibitors, as they increase Km (like a competitive inhibitor) and decrease Vmax (like a non-competitive inhibitor). Background What an interesting question! In theory, a reversible ...


This is a tough question. I was reading this paper Patrono, C., et al. "Clinical pharmacology of platelet cyclooxygenase inhibition." Circulation 72.6 (1985): 1177-1184. and they seemed t mention this paragraph in the introduction. Platelet Cycloxygenase or prostaglandin (PG) H synthase (i.e., the enzyme that converts arachidonate released from ...

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