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Most reactions require an activation energy to cross an energy barrier (this you may already know) after which the reaction is downhill. Even though enzyme catalysed reactions have a relatively lower activation energy compared to that of an uncatalysed reaction, there is still a transition state that has a higher free energy compared to the products. This ...


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It seems that beta-glucosidases do not require co-factors but some alpha-glucosidases are co-factor dependent. Some bacterial alpha-glucosidases (GH4 family) require NAD+ to function (Hall et al., 2009). Thermotoga maritama alpha-glucosidase (GH4 family) requires Mn2+, in addition to NAD+ to function (Lodge et al., 2003). Ferroplasma acidophilum alpha-...


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Apparently not for lactase and β-galactosidase, as one might expect for this sort of hydrolytic reaction. There are also Wikipedia entries for maltase, sucrase and trehalase with references you can follow up to check yourself.


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Briefly: According to the paper you are linking, Abl-BCR is not "recognized" by the drugs in the active or the inactive state but rather it assumes a conformation that is similar to the active or inactive state of Abl once the drug binds. Simply put: the paper does not study what conformation Abl was in before the drugs bind, they rather discuss the ...


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I think Feynman is referring to the second law of thermodynamics. The entire statement is this: The most important feature of the cycle of Fig. 3–1 is the transformation from GDP to GTP (guanosine-di-phosphate to guanosine-tri-phosphate) because the one substance has much more energy in it than the other. Just as there is a “box” in certain enzymes for ...


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Well, saliva (or the rate of production of saliva in your mouth) can tell you a lot about health, but the information you acquire is extremely general, so it won't really give you an entire health analysis in terms of diseases, sugar levels, body temperature, likewise. As for what saliva does tell about your health, here is an extract from a source: "...



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