Hot answers tagged fatty-acid-synthase
Fat is, in molecular terms, triacylglcerol. In order to be absorbed in the small intestine triacylglycerol molecules are broken down by lipases into fatty acids and monoacylglycerols. Once these have got across the enterocyte membrane they are reassembled into triacylglycerols and packed up into a special class of lipoprotein particle, a chylomicron, which ...
I think the reason is that there would be so much more oxidative stress in our body to convert PUFAs then to saturated ones. Special system should also be needed for the fine regulation.
The diversity of fatty acids produced by an organism is limited by the diversity of enzymes which synthesize them. Unsaturated fatty acids contain carbon-carbon double bonds which do not isomerize. The capacity for humans to produce cis fatty acids is probably selected for because of their lower melting point which prevents arterial clogging. Cold blooded ...
The textbook descriptions of fatty acid synthesis can be confusing because although the underlying chemistry of the process is universal, the way that it is organised is different in the systems that have been characterised, which include E. coli, yeast and vertebrates. In vertebrates: The fatty acid synthase is a dimer of identical multifunctional single ...
I think this question can also be said to be - how can the Atkins diet work? Atkins and other low carbohydrate diets sound counterintuitive. They vary in details, but the basic theme is: cut back on carbohydrates - e.g. bread, sugar, fruit, pasta, milk etc etc. But eat as much fat and protein as you like - e.g. steak, ham, bacon, eggs, cheese etc etc. ...
I found this reference: "Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells". Cerulenin is not a magic bullet, but in some cases it may help.
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