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Yes, these sequences exist and they are called "silencers" (surprising, right?). There are different mechanisms by which this silencing of genes can happen. In the "classical" way the silencer is bound by a transcription factor which either passively suppress the gene by hindering the binding of specific transcription factors or by actively preventing the ...


1

You nailed down what enhancers are (canadianer give a good explanation too, while not answering the question in my opinion). For understanding the authors statement you first need to know that: Lineage-specific and signal-dependent transcription factors are specific classes of transcription factors. Those are TFs that require external signals for ...


2

Enhancer is a just a term for a regulatory region distant from a gene that contains specific sites where transcription factors bind. As it happens, a single enhancer can contain DNA binding sites for multiple transcription factors. For example, an enhancer called TESCO, which regulates a gene called SOX9 (involved in sex determination) has binding sites ...



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