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11

...would then be his offspring at risk? Why? No. Generally speaking, fathers do not pass on their mtDNA (Mitochondrial DNA). Why? Because the mitochondria present in oocytes (egg cell) is the mother's, as every oocyte directly inherits the mother's mitochondria when they are made in the reproductive organs. The mitochondria that the sperm from the ...


6

I would suggest searching the name in any trusted genetics database such as NCBI's GenBank (http://www.ncbi.nlm.nih.gov/genbank/). You can just Google search it, but it may take a little longer to find useful information that way. I hope this helps and good luck with your research, CDB


5

Take a look at this schematic of a mature mRNA. [source] The coding region (ie the part that is translated) is between the start and stop codons, but the 5' and 3' untranslated regions (UTRs) are also transcribed by RNA polymerase; these are part of the first and last exons, respectively. The transcription start site is labelled right in front of the 5' ...


5

TL;DR: Ubiquitin. Occasional occurrence of paternal inheritance of mtDNA has been suggested in mammals including humans. Clearly, spermatozoa have mitochondria; they make the energy needed for motility. Paternal mitochondrial DNA (mtDNA) does enter oocytes. It is a persisting fallacy that only maternal mtDNA is present in humans because only oocyte ...


4

So, the very first map of the human genome was of a few pooled samples with a single nucleotide called at each position. This is basically okay, though, because humans are 99.9 (with possibly a few more 9s) % similar to one another. So you can get a lot of broadly-applicable information out of a single individual's DNA. Further genome-mapping efforts ...


4

According to this website, it is a mnemonic for "lambda excision". I have also found this usage in scientific literature (Harami et al., 2013). However, neither of these sources reference anything and I cannot find any defining paper. Almost all papers simply refer to it as lexA. As far as I can find (it's difficult to dig up these old papers), this is how ...


4

I'd go with Lambda Excision A. Terms like lex or rec often stand for what'd be termed a mnemonic, where for example rec may stand for recombination, or umu for UV mutator. The naming conventions can be difficult. Edit: A 1981 study by Roger Brent and Mark Ptashne notes some data from initial studies that showed the lexA repressor downregulated a number of ...


4

There is nothing intrinsic to DNA methylation itself that requires it to repress transcription. Simply, it affects sequence recognition by proteins. CpG methylation can prevent transcription factor binding and/or recruit proteins that inhibit transcription, either competitively or through chromatin condensation. This is why it's generally associated with ...


4

Was getting long in the comments. In light of your comments, you might be interested in Gene-set enrichment analysis (GSEA). You can do a GSEA using your set, the other one coming from reference databases such as MSigDB (see here). You can categorize your list by gene families using this technique for example. You can get an idea of what cellular process ...


4

TL;DR: Chymosin is similar to pepsin and I couldn't find any evidence of functional/expressed chymosin gene in human genome. It seems like a common misconception that chymosin is functional in humans. Already in 1940s it has been shown that rennin (aka chymosin) is absent from "gastric juice" in adult humans. Genetically there is only pseudo-gene for ...


4

Physical and genetic interactions are described in the help wiki, accessed via the top menu bar on the page you linked to. Physical interactions refer to experiments where the gene product (protein) has been shown to physically interact with another protein, such as by co-immunoprecipitation, fluorescent staining, yeast two-hybrid system, etc. Genetic ...


4

You mix up translation and transcription. Transcription creates mRNA from DNA template. Transcription also includes splicing, that is excision of introns so that mature mRNA contains only exons. In your example it goes like that: DNA (chromosome): ---A----B--...--Dstop---E--- premature mRNA: A----B---...---Dstop--E---polyA mature mRNA: AB..DstopE-polyA ...


3

If the Cold Spring Harbor Laboratory is considered a reputable source (it should be), you can check out their Defining the gene page which has an overview of the beads-on-a-string theory, and how it was disproved by Seymour Benzer. You could also try to find Benzer's original paper, although it doesnt seem to be available online. Related and possibly ...


2

It depends; what species are the genes from? Some organisms have extensively annotated genomes, and actively curated species-specific databases, while other species may not even have a reference genome sequence available. By itself, a priori, if you were lucky, about all you list would tell you was how to spell the names of those genes--if you're lucky. But ...


2

Also try putting the list through Reactome or String DB to see if you see mapping to certain pathways. http://string-db.org/ You can also put lists through ConceptGen to carry out ontology based analyses http://portal.ncibi.org/gateway/conceptgen.html


2

Let's go through the possible answers. Which of the following could be predicted? Not (1), because we don't know whether selection favors or disfavors the recessive alleles. Not (2) for the same reason. Not (4) by definition. Not (5) because recessive alleles don't magically become dominant. This leaves us with (3), which also seems correct: not only do we ...


2

These are not gene ids, but groups of orthologous genes -- try to search for the ids on Google, I can find this page http://cegg.unige.ch/orthodb6/fasta.fasta?ogs=EOG6STSR2&swaptree= and thus you should be able to download the sequences and ids from OrthoDB. Note that, strictly speaking, the are no Ensembl ids for Drosophila, only FlyBase ids that are ...


1

The article probably had a scrap of truth to it. Ageing is not plastic and longevity can be altered in a variety of ways. Although caloric restriction seems to affect longevity the most, there are also longevity genes from a range of cellular processes that have been identified in yeast and mice, indicating that ageing is a whole system process. But none of ...


1

In tissue culture and cell engineering fields, the word "immortal" is often used to express something else instead of human or animal life spun. When you take cells from human tissues and grow them in test tubes--although flasks or dishes are used in reality--, cells stop growing after long term culture. They say it is cellular senescence. Several genes ...


1

I might be wrong, but aren't numbers $n$ and $m$ are connected as $n=m+1$? Answer seems to be combinatorial: how many combinations of $n$ objects can be assembled under certain restrictions? Namely, how many isoforms certain gene can have. Restrictions include: how many exon-intron junctions on codon (or precisely between codons), how many exons are ...


1

From the comment section: We don't have to see the actual changes. It's like chemists who will mix compounds together and obtain a new molecule. They dont see the chemical reaction per se but can test the new molecule to make sure what they predicted would happen had happened. Finally we often use fluorescent proteins to track some of the modification ...


1

Assuming each gene symbol represents a unique gene or protein (this may not be true; see for gene name aliases in e.g. NCBI Entrez gene) you can get a lot of information programmatically. Below is an example using R and Bioconductor resources. Define your list of genes: # list of gene symbols, here we focus on one. > genes <- "KRAS" Load the ...


1

I wouldn't expect different methods to give the same results. Further, why are you even testing non-normalized datasets, the results of that are completely and utterly useless for any purpose other than showing that normalization is important. In addition, an T-test is a special case of an ANOVA (and of course limma is itself using a moderated T-test, though ...


1

Delivering siRNA in vivo is a difficult prospect, but has been overcome in research environments and several commercial in vivo solutions are on the market see examples from Life Technologies here. The bigger problems come from potential off-target effects. siRNA tend to be double stranded and both the 'guide' and 'passenger' strand can occasionally target ...



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