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First of all you need to clarify what exactly is the output that needs to be regulated. We often say regulation of expression of a gene but what expression ultimately leads to is the activity of the gene (whatever it might be: enzyme based catalysis, cytoskeletal rearrangement, response to an extracellular signal). Activity of course depends on the ...


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I don't understand your system of 3 genes regulatory network question, but I can answer your general question regarding transcription factor self-regulation of transcription/gene expression. Yes, in biology, there are transcription factors that bind to their own gene's promoter-proximal region (on DNA) and regulate their own gene's transcription. There are ...


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Both genes and alleles are sequences of DNA. A gene will code for a trait, say hair colour, while an allele will be the variants of that gene (say the alleles coding for blonde, brown, black, and red hair). It's almost like cookbooks: two cookbooks (the DNA) might have a recipe (gene) for bread but they use slightly different instructions (alleles) ...


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Alleles are basically subtypes of a gene. At the time of Mendel, the molecular nature of inheritance was not known so the original definition of gene refers to "some" inheritable molecular entity inside the organism that is responsible for a trait. Alleles are different "flavours" of a given gene. For example there is a gene for flower colour, there can be ...


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Can you provide the gene of interest? You can usually search Entrez for the gene symbol in the dbSNP database, which will pull up a NCBI Entrez page for SNPs located in the gene and will also give an indication of their clinical significance (benign or otherwise). Alternatively, if you have a specific disease in mind, you can check more specific ...


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Unfortunately there are no rigorous naming conventions for a gene. While some are based on actual molecular function or phenotypic effect, others can be totally bizarre names. Some are actually based on the test-tube and purification fraction labels. Some are named on characters from Mythology, novels etc. I'll add some examples: SNARE (proteins involved ...


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Welcome to Biology.SE. To my knowledge there is no good rule on how to name genes. The first person to name a gene or an allele is free to just pick up a that (s)he finds easy to remember and eventually intuitive. Sometime the author just picks a funny name. Here are a few examples from Drosophila melanogaster data base: bag of marbles: involved in ...



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