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I may have approached this problem from the wrong direction, so here's my attempt at an answer: For gluconeogenesis to function, glycolysis needs to be shut off. Glycolysis feeds the TCA cycle with Acetyl-CoA through the decarboxylation of pyruvate, and without glucose as a source, we need to look to other methods of generating OAA to make into PEP. We ...


Got it. The ratio of [NADH]/[NAD+] is about 100000 lower in the cytosol than it is in the mitochondria. The conversion of malate to OAA reduces a molecule of NAD+ to NADH, and that NADH can be used for the later step in gluconeogenesis: the conversion of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate requires a molecule of NADH.

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