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High intracellular glucose. Affects: all cells that do not depend on insulin to take in glucose. Examples: neurons [1], kidney cells, retina cells. Causes: high extracellular glucose (in most cases hyperglycemia) Effects: promoting necrotic cell death through $H_2O_2$ (peroxide) formation, which may participate in the development of diabetic ...


1

Too much glucose leads to the formation of advanced glycated end products, which deposit in tissues like glomerulus and cause disease like diabetic nephropathy. Also glucose is osmotically active, so when it starts appearing in urine (because of its high levels in blood), it leads to polyuria, following which the lost water is recovered from body tissues, ...


1

Glucose transports from the blood into the cells via facilitated diffusion. This means that glucose goes from higher concentrations (in the blood) to lower concentration (in the cell). Therefore, if you have super high glucose concentrations in the blood, you will have a ton of glucose in the cells. Glucose will oxidize by itself, thus it will contribute a ...


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The glucose can react with proteins, damaging them. This is called glycation. Note that glucose is the preferred body fuel and has a 10 fold lower ability to cause glycation than fructose. http://en.wikipedia.org/wiki/Glycation



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