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I think this is mostly caused by hyperventilation. The excessive breathing disturbs the balance between CO$_{2}$ and oxygen in our lungs. This will cause respiratory alkalosis (the blood pH, which is normally strictly regulated, gets higher), which can cause dizziness, headaches and fainting. The shift in pH can also disturb the eclectrolyte balance, ...


Yes, it does cause lesions in rats, although I don't think it's been observed to do so in humans. See:


Pressing on the chest changes the concentration of dissolved gasses in the blood stream. Your brain reacts due to excessive oxygen in the blood. This is oxygen toxicity. Why the brain generates vivid imagery when unconscious is a big topic. There's a theory that correlates dreams with a lack of cognitive stimulation. This is called autostimulation and may ...


From your article: Sig-1Rs localize at the interface between the endoplasmic reticulum (ER) and mitochondrion, which is known as the mitochondria-associated ER membrane (MAM). Consequently, they are found in a variety of areas within the central nervous system as well as in other types of cells throughout the body (notably cardiac cells). An ...


I think you'll like this article. It's on monoamine release / reuptake inhibition for a host of different psychedelic and empathogenic drugs. This wakefulness inducing effect you describe for LSD is widely reported for all common 5-HT2 mediated psychedelics.

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