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Yes, it does cause lesions in rats, although I don't think it's been observed to do so in humans. See: http://www.druglib.com/druginfo/namenda/description_pharmacology/


From your article: Sig-1Rs localize at the interface between the endoplasmic reticulum (ER) and mitochondrion, which is known as the mitochondria-associated ER membrane (MAM). Consequently, they are found in a variety of areas within the central nervous system as well as in other types of cells throughout the body (notably cardiac cells). An ...


I think you'll like this article. It's on monoamine release / reuptake inhibition for a host of different psychedelic and empathogenic drugs. This wakefulness inducing effect you describe for LSD is widely reported for all common 5-HT2 mediated psychedelics.

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