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Histamine is a neurotransmitter that plays a key role in allergenic responses, sleep, alertness, cognition and gastric acid synthesis and secretion. It binds primarily to the four types of histamine receptors, H1 (responsible for alertness, cognition, allergenic responses), H2 (responsible for gastric acid synthesis and excretion), H3 (which serves as the histamine autoreceptor) and H4 which seems to play a role in immune function.

Histamine is a neurotransmitter that plays a key role in allergenic responses, sleep, alertness, cognition and gastric acid synthesis and secretion. It binds primarily to the four types of histamine receptors:

  • H1, responsible for alertness, cognition, allergenic responses.
  • H2, responsible for gastric acid and intestinal excretions and motility in general.
  • H3, which serves as the histamine autoreceptor.
  • H4, which seems to play a role in immune function.
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