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A Google search for "Huntingtons disease gene discovery" yielded this page at the Nature Education Scitable website. The following citations are provided regarding the molecular basis of HD: Huntingtin (HTT) was the first disease-associated gene to be molecularly mapped to a human chromosome (Gusella et al., 1983)2. Ten years later, scientists ...


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It was fascinating because Huntington himself described what we now call genetics before the field existed. Then to locate the gene scientists used essentially trial and error. They took enzymes that cut different parts of the DNA and looked at which of these were inherited. If it were inherited then there would be cuts made, otherwise not. Then they matched ...



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