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Haemophiliac females are rare but they can survive just like affected males do. However, the case is slightly more complicated in women because of menstruation. I could not find an article from any medical journal but this site seems authentic enough for a reference.


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It may help to think about the genealogy of the sequences in question. In general, we suppose that all DNA sequences from organisms are related by a set of processes. A particularly important process relating DNA sequences is replication. This establishes a parent-child relationship between DNA sequences in one round of replication or an ancestor-descendent ...


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How far could we go towards engineering a space-durable human species? I think this question is likely to get closed as off-topic. It is extremely hypothetical and would be a better fit on WorldBuilding.SE. But here is my messy attempt to answer this question. Assumptions So, I guess in your question, you assume that we know everything about how our ...


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DNA duplication (imagine, we PCR it) will net be enough. First of all, you also will have to duplicate and pack mitochondrial DNA into the cell. next, as been mentioned, epigenetic modification (methylation) and histone packing are crucial for proper development. And these markers should essentially replicate state of the host cell. My best guess is that ...


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The answer is no, and it is because sequence of the genome is not all information that is required for gene expression and development, there are also epigenetic factors. A lot of patterns of epigenetic marks, such as most of DNA methylation and some histone modification patterns, are set during parental germline development, and these marks are ...


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There are multiple answers to this question depending on who you ask (meaning, what their field of expertise is). The biological dark matter from the wikipedia article in question seems to mean sequence from metagenomic samples which was not assigned to any of our commonly known domains of life. That might not necessarily mean that it does not belong to ...


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Take a look at this article: http://phys.org/news/2014-01-scientists-biological-dark.html Is this the same "biological dark matter" you're asking about? If so, it sounds like what used to be called "junk DNA" or "non-coding DNA", which is what it was referred to as up until a few years ago when scientists discovered it is actually regulatory DNA, very ...


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I think it's best to break this question up in to two parts: What mutations account for red hair and fair skin in humans How might these same mutations affect pain sensation MC1R variants & red hair The MC1R gene encodes a transmembrane receptor protein (belonging to a very common family of receptors), called melanocortin 1 receptor. It also has ...


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A DNA locus may have two (or more) variants (alleles), but there isn't one termed a main or default variant. In the example you cite, Myśliwska 2009, the only asymmetric distinction between the G and C alleles that I could see was in this passage: The polymorphic region −174G>C of IL-6 encoding gene is implicated in transcription of this cytokine. The ...


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In this case, G is the genotype used for comparison because that's what's in the reference sequence for humans. Of course, this raises the question of why that's the reference. The answer is that it's because that's the sequence from the sample used to create the BAC that was sequenced and used to create that portion of the reference sequence. Of course, ...


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[..] G is the default and C is the polymorphism An allele (or just a nucleotide variant) cannot be "the polymorphism". There is polymorphism, if a given locus (or just a given nucleotide position) is polymorphic, that is, if as this position, there are different variants existing in the population. Therefore, an allele cannot be called polymorphism, ...


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A gene being dominant does not necessarily imply the gene is also common. An easy counterexample is Huntington's disease. The gene is dominant, and only one mutant allele of huntingtin would result in development of the disease. However, the allele prevalence of the mutant is low in the general population. In the absence of a selective advantage of green ...



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