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Before I actually answer your question, let us clear up some problems in your assumptions. The fact that you expect 50% similarity in siblings is a full of several assumptions. Imagine a case of a simple diploid organism with 2 traits. To restate your assumption, if both the parents are heterozygous in either of the two traits, and the alleles present in ...


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You are correct that brachydactyly is a dominantly inherited disorder and is usually caused by mutations in the BMPR1B gene. However, not everyone who has the mutation, will have clubbed thumbs (the phenotype). This is due to a phenomenon known as penetrance and expressivity. Penetrance essentially is an all-or-none phenomenon whereby certain individuals ...



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