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To achieve whole genome alignment between a genome as large as a human, and as small as an archea organism, is possible, but in the end, you'll have to strain your eyes to see patterns. The archea genome is about 1-5 million bp long, whereas the human genome is about 3.3 billion bp long (that's a thousand times too large). In practice what this means is ...


The same question sticked in my mind a month ago. Even @terdon gave an explanatory answer, I want to make a small contribution. When I asked similar question on seqanswers *, one of users gave the link of the study Ashley Lab in Stanford. They generated the "Synthetic major allele human reference genomes". (1) They combined the current reference sequence ...

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