Tag Info

New answers tagged

1

To find candidate proteins which can be used as peptide vaccine, these need to fulfill some criteria: The most important is that the peptide (or protein) used for vaccination shall not have a closely relate sequence in the organism in which the vaccination shall occur. Otherwise either no reaction (due to immunologic tolerance to self) or an autoimmune ...


1

According to wikipedia: HIV protease inhibitors are peptide-like chemicals that competitively inhibit the action of the virus aspartyl protease. These drugs prevent proteolytic cleavage of HIV Gag and Pol polyproteins that include essential structural and enzymatic components of the virus. This prevents the conversion of HIV particles into their ...


5

Your answer is correct. HIV-1 encodes a single homodimeric aspartic protease, with each monomer containing the classic Asp-Thr-Gly motif, and the dimer's active site being formed with the two monomeric active sites creating a cleft where the proteolysis takes place. In it, water acts as a nucleophile in conjunction with the aspartic acid residue to hydrolyze ...


1

One possibility is that these antibiotics could disrupt your normal gut bacteria. Given that your gut has the surface area of a tennis court and is typically coated with symbiotic microbes, antimicrobial therapies could dramatically change the population dynamics of your gut ecosystem. One might imagine that the immune system of the gut is in homeostasis ...


1

This is an important topic in immunology, especially for vaccine development. MHC or HLA is a molecule expressed by some cells of the immune system which acts like a "catcher's mitt" and "presents" short snippets of protein to other immune cells. Other molecules act alongside MHC to provide co-signals which promote or suppress immune attack against the ...


0

Actually it can help by curing specific types of cancer e.g. Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia. But ofc. it does not help in every case. You can live without B-cells, but you cannot live without liver... So yes it can be used by designing a therapy for a disease, if that's the question.


0

Bone marrow transplant for leukemia and multiple myeloma. Uses extensive HLA typing like you said are you looking for additional diseases?


1

I don't know any true disease associations, but since this question still has no answers, I'll offer one... One class of associations you might be missing is difference in drug response. Patients with HLA-B*5701 are known to be hypersensitive to abacavir. Genetic screens are available to screen for this allele, and this information is used clinically.


2

The source article had several major errors in it. I wouldn't trust any of it. Vaccines are designed to protect against invaders that are encountered rarely - not all the time. This is one of the major errors. There is a vaccine for chicken pox now - an infection which affected approximately 4,000,000 cases per year in the US before the vaccine. That ...


2

TL;DR the huge block of text: The innate immune system only recognizes certain antigens, called PAMPs. The activate immune system usually requires the immune system, but it can get around this in some cases. You're on the right track. Pathogen-associated molecular patterns (PAMPs) Innate immune cells such as macrophages and denritic cells ...


3

Not true. Vaccines were initially made for the highly contagious diseases that used to cause epidemics (which obviously means they were not rare). The efficacy of a vaccine depends on multiple factors which includes adaptability of the pathogen. The all-the-time encountered pathogen that the article is talking about is HIV; the reason for why no ...


4

First, I want to note that ddiez has a good answer, but I thought this was good question to have a more expanded answer on immunology and pathogenesis. The First thing we need to establish what is a "cold". The most common cold is rhinovirus (HRV), but the second place holder is a little harder to define. For example, respiratory syncytial virus (RSV) ...



Top 50 recent answers are included