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Understanding the link between the size of the tumor mutanome and its immunogenicity requires a basic understanding of T-cell development and regulation. When normal human cells degrade proteins via the proteasome, some fragments of these proteins, called peptides, are bound to specialized cell-surface proteins called MHC. T-cells express a specialized ...


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No, MHCII mismatch can also lead to transplant rejection, though through different mechanisms. CD8+ Tcells (that recognize class I) may become activated and directly kill donor cells*, and some NK subtypes can see the lack of self MHCI and also induce cell death. MHCII mismatch on antigen presenting cells (APCs) brought along in the tissue may activate CD4+ ...


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The "proper" term to use in a case of growth retardation in children is "failure to thrive", abbreviated as FTT. Celiac disease is one of the most common Organic endogenous (genetically based) FTT syndromes. The main cause of FTT in pediatric celiac patients is malabsorption. In a case of insufficient vitamins and nutrients absorption the child will (have) ...


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During stress glucocorticoids, which are steroid hormones produced by adrenal glands (such as cortisol and corticosterone), are released into the blood-stream. These hormones have anti-inflammatory effects. You may say that they suppress the immune system. The circadian rhythm, which controls the sleep-wake cycle, also controls glucocorticoid secretion, ...



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